Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
...nstrated early efficacy anddefined the appropriate dosing regimen for Phase II studies. Promising data arenow emerging from the current pivotal Phase II trial in the U.S. that involvespatients following relapse after initial AML chemotherapy. A preliminaryanalysis of these data show that CMA-676 given alo...Study Confirms Safety Of Common Heart Drug
...learned a lot more about the drug so we can tailor dosing more specificallytoward a particular patient," says study lead-author Dr. Kristin M. Williamson,adjunct assistant professor at UNC's School of Pharmacy. "And what we've shownin our study is that compared with 20 or 30 years ago, the frequency of dig...UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
...ich stage of cancer in mousemodels, and to develop dosing regimens that are fine-tuned to target thesespecific stages of disease progression." The ultimate question, of course, the researchers emphasized, is whether thedrugs will have similar effects in humans, and the answer is presently unknown.The resear...Progress In Cancer-Vaccine Studies: Simpler, Safer Approach Producing Encouraging Results
...ut onetenth of the maximum dose -- suggesting that dosing trials of biologic therapiesrequire a radically different design. At moderate doses, IL-12's most seriousside effects were tenderness at the injection site, tiredness and mild fever.Higher doses were more toxic and much less effective. In addition to......two months, Dr. Burnier and his team monitored the dosing patterns andblood pressure levels of 29 patients w...Theresearch showed a strong link between lapses in dosing and increases in bloodpressure, and overall there was a statistically significant inverse correlatio...Bristol-Meyers Squibb submits NDA for new formulation of once daily videx(R)(didanosine)
...tly, BMS launched a 200 mg tablet which simplifies dosing to two tablets once a day. Patients must take at least two of the appropriate strength tablets to provide adequate buffer to prevent gastric acid degradation of VIDEX. VIDEX tablets are the first and only once-daily nucleoside analogue reverse tra...Analysis of study looks at why quitters return to smoking
...disease; in these patients, a reduced frequency of dosing may be required. Zyban should also not be used in patients who have or have had a seizure disorder or who have a history of or are currently diagnosed with bulimia or anorexia nervosa. It should also not be used in people who are taking or have rec......ned levels in infected tissues making short course dosing possible. The data necessary to include the singl...oduct label currently includes a 5-day, once daily dosing schedule that may make finishing medication easier than with conventional 10-day antibiotic regimens...... studies were looking at adverse events, efficacy, dosing and interactions with other medications. The largest study, the Optimised Parkinson's Therapy in Long-Term-Use Study (OPTiL) involved 721 patients with advanced PD, which were insufficiently controlled by their previous therapeutic regimen and requi...New discovery may revolutionize treatment for pain related to surgery, illness and injury
...olecular structure to achieve clinically effective dosing in targeted groups of nerves, Filler said. This work marks an important advance, because drug treatment of nervous-system disorders is often hindered and sometimes precluded when the precise site of the injury or disease cannot be reached with adeq...In a new observational analysis, Risedronate significantly reduced nonvertebral fracture risk
.... Patients should pay particular attention to the dosing instructions, as failure to take the drug accordin...e overall incidence of adverse events with the two dosing regimens was similar. The most commonly reported adverse events regardless of causality were infect...Largest ever overactive bladder study published in leading urology journal
...said Dr. Van Kerrebroeck. Furthermore, once-a-day dosing of tolterodine provides maximal patient convenience.......The dose of clarithromycin should be halved or the dosing interval doubled in patients with severe renal impairment (CrCl<30mL/minute). Pneumonia is an infection or inflammation of the lungs. Community-acquired pneumonia is the most common type of pneumonia, affecting two to three million Americans eac...12-hour ADHD drug as effective as thrice daily doses
... be as effective as the standard three-times-a-day dosing regimen, a clinical trial conducted by University ... for ADHD. The double-blind design involved three dosing regimens: immediate-release methylphenidate given three times a day; extended-release methylphenidat....... Patients should pay particular attention to the dosing instructions, as failure to take the drug according to instructions may compromise clinical benefits and may increase the risk of adverse events. About the Alliance for Better Bone Health The Alliance for Better Bone Health was formed by Procter & ...Drug regimen adherence key in keeping babies virus-free, study suggests
...ikely to adhere to the monthly dosing schedule. Children whose families had difficulty with transportation to the doctor's office were less likely to receive all of the doses. While most of the parents said cost wasn't a factor...7-day-on, 7-day-off regimen could reduce cost, toxicities of HIV therapy
...icant short- and long-term toxicities, complicated dosing regimens and associated problems with adherence, and the development of drug resistance. In addition, high monetary costs have precluded the widespread use of HAART in resource-limited countries. "With further research, we would hope that the appr...Dosage appears to be a critical factor in cocaine vaccine
... sense of whether we can increase the frequency of dosing to perhaps five times to see if we can get the level of antibodies even higher." The 34 subjects enrolled in the Phase One trial were abstinent cocaine abusers who were confined in a residential drug treatment program. Of that number, 27 completed th...Cyclists' 'blood doping' associated with cerebral blood clots
...le doping agent, the combination of drugs and high dosing of vitamins likely produced this athletes condition," says study author Eduardo Rocha, MD, Ph.D., of Clinica Universitaria de Navarra. "With the practice of blood doping among athletes becoming more popular, more research is necessary to devise new m...