New leukemia drug shows promise in overriding all Gleevec resistance
...Temple University researchers have developed a new drug that could potentially treat all forms of Gleevec-... and his research team sought instead to develop a drug that would circumvent all of the mutations and therefore all forms of resistance. They focused on ot...More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
...er, Merck & Co., "raises many questions concerning drug policy, scientific evidence, and treatment alterna...ib has brought to the forefront concerns about the drug safety system that have been raised before. These issues must be addressed now if we are to restore ...Living in a disadvantaged neighborhood may increase HIV risk
...rhoods to stress and stress to increased injection drug use in male study participants. This is the first ...chers examined data from a survey of 701 injection drug users from the Self-Help in Eliminating Lethal Disease (SHIELD) Study, an HIV prevention interventio...Study estimates number of excess cases of coronary heart disease caused by Vioxx
The arthritis drug Vioxx could have caused an estimated 88,000-140,00...rket at the end of September 2004 after use of the drug was linked to heart problems. David J Graham (Office of Drug Safety, US Food and Drug Administratio...Clinical trial participants fare no better, no worse than other patients
...g was published against a backdrop of debate about drug trials for popular pain-relievers and about whethe...nduct and participate in them mean that when a new drug or treatment is applied to a general population, the results might be different. A recent article i...Changing the timing of cancer vaccines
...ve and can accomplish their work. However, using a drug that results in the linking of two identical molecules (a process called dimerization), Spencer and colleagues found that they could wait until the dendritic cells got to the lymph nodes to activate them. That significantly extends the period during ...Sildenafil effectively treats enlarged hearts, mouse study shows
...ins have found that sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in million...akdown of cyclic GMP," he says. The makers of the drug had no involvement in the design or support of the research. PDE5A is also the biological pathway b...Antioxidants have no effect on Lou Gehrig's disease
...igram, under-the-skin injection of the antioxidant drug acetylcysteine once a day. In the third study, pat... cost," Orrell says. There is no cure for ALS. The drug Rilutek (riluzole), which is not an antioxidant, is the only treatment approved by the Food and Drug...Vioxx went mostly to patients who didn't need it, Stanford researcher says
...l profession has a term for expanding the use of a drug beyond its intended target population: "therapeuti...nsion mean that millions of people paid more for a drug without reaping a substantial medical benefit, but it now appears they unnecessarily exposed themsel...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...00 alone, Vioxx was the most aggressively promoted drug on the market, including $161 million of direct-to-consumer advertising. The researchers wondered how many of these prescriptions were going to patients who were not likely to benefit from them -- those with minimal risk of the gastrointestinal probl...JCI table of contents, January 20 2005
...ip on the rebound After a break in antiretroviral drug therapy in HIV-positive patients, the virus reboun...-positive patients has generated hopes of reducing drug toxicities, costs, and total treatment time. However there has been concern regarding how this on an...T cells target HIV in a relationship on the rebound
After a break in antiretroviral drug therapy in HIV-positive patients, the virus reboun...-positive patients has generated hopes of reducing drug toxicities, costs, and total treatment time. However there has been concern regarding how this on an...Pharmacist review does not keep older people out of hospital
...rugs, removed out of date drugs, reported possible drug reactions or interactions to the general practitio...rugs, with a resultant increase in side effects or drug interactions. Either way, more effective forms of medication review need to be established, say the ...Common antidepressants lower effects of tamoxifen in many women
...sants may hinder the effectiveness of tamoxifen, a drug commonly administered to breast cancer patients. T... activity may help clinicians anticipate important drug interactions. Genetic testing may help identify a group of women who may experience greater benefit ...Technology that could double the effectiveness of cancer drugs studied at Yale
...ance to many drugs. Currently, physicians select a drug and must wait about six months to see whether it i... assay based on a biological principle that when a drug is effective, it will induce apoptosis (cell death) in the cancer cell. If the cancer cell is resist...Insulin resistance intervention after stroke focus of $33 million grant
...e affects up to 50 percent of stroke patients. The drug being tested, pioglitazone, reduces insulin resistance and is currently approved for use in diabetes treatment, but it has not been tested for prevention of vascular disease in non-diabetic patients. Over 400,000 Americans survive an ischemic stroke ...New research shows heroin use falling across Scotland
...arch shows a near 8% drop in the number of problem drug users since 2000. The report entitled 'Estimating...cting, but around 18,737 still inject. The highest drug injecting prevalence is in the Argyll & Clyde, Greater Glasgow and Grampian NHS Board areas, where a...Low-dose aspirin and stomach ulcer medications better for heart patients with GI complications
...tomach ulcers rather than taking the anti-platelet drug Plavix, which has been thought to reduce bleeding ...n because of previous bleeding ulcers be given the drug clopidogrel (Plavix), which has been found to be marginally better than low-dose aspirin in preventi...Post election 2004: What's in store for health policy
...ealth plans, and early experiences of prescription drug discount cards - how will these critical issues influence the nation's health policy agenda in 2005? The National Health Policy Conference, sponsored by AcademyHealth and the journal "Health Affairs", provides an in-depth look at the health policy is...Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
...four weeks following surgery or from the date when drug treatment began. Levels of both cGMP and ammonia in brain were measured using a microdialysis probe. Results showed that while rats with the portacaval shunt showed a reduced learning ability, treatment of shunted rats with sildenafil restored their ...