Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...uced no natural leptin, it was easier to track the effects of the artificialleptin. Results of the study showed that leptin does, in fact, signal the sympatheticnervous system to release noradrenaline onto brown fat, sometimes referred to as "good"fat. This step appears to be near the endpoint of the leptin...Digital Speech Analysis Tests Sobriety
...roduced under emotional stress or with linguistic effects such astalking quickly or slowly, loudly or softly. "Given her robust results in the differentiation of styles ofstressed speech, we thought that this type of analysis might showcharacteristic changes in speech produced under alcohol," Chin said. F...Testosterone May Affect Learning Skills; May Be Put In Tablet Form
...g and it highlights the importance of studying the effects of sex hormones on brain function," says Adrian Do...jections, often causing mood swings and other side effects in some men. Studies have shown that recently developed testosterone skin patches also deliver the h...Maternal Exposure To Crack Cocaine Produces Stressed Newborns
... with alcohol and marijuana. Alcohol can boost the effects of cocaine,and most of the crack-smoking women in ... to providescientifically valid findings about the effects of substance exposure in thewomb. "Newborns who were exposed to crack looked like normal babies but...Discovery Hints At Multitude Of New Targets For Drugs
...lated by drugs customized to produce more targeted effects on thebody, said the scientists who made the disco...ame receptor to trigger only certain of its normal effects in the body,but not others. The finding, if confirmed, could point the way to a new wave of...Tacrolimus Stops Rejection Of Kidney Transplants
...ents require additional therapy; however, the side effects of repeated courses of standard antirejection therapies-increased risk for infections or for a form of lymphoma associated with these drugs-are excessive. Tacrolimus, however, reversed rejection in 75 percent of patients with repeated or uncontrollab...Study Demonstrates Safety & Effectiveness Of Asthma Drug
...wo groups could beattributed to the treatment, the effects were small and deemed to be clinicallyunimportant. Asthma Clinical Research Network (ACRN) was created in 1993 by the NHLBIas a five-year program to expedite design and implementation of clinicaltrials on approaches to managing asthma. The albuterol...ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function
...estored. The team is still evaluating thevirologic effects of HAART on lymphoid tissue. Follow-up studiesalso will examine immunologic function after longer term HAART,and after changes in therapy for participants who fail to respond. Data are being analyzed to ascertain the mechanism underlyingrestoration ...Childhood Sex Abuse Impacts Adult Relationships
...ave some protection against the long-term negative effects that sexual abuse has on other college women who w...study is one of the first to explore the long-term effects of sexual abuse on attachment in later life and to examine the role of childhood attachment relation...ACTG Protocol 185 Enrollment Halted
...ncy for her own health. No short-term serious side effects in either women or infants were observed in either Pediatric ACTG Protocol 185 or 076. However, information on long-term safety of antiretroviral drugs in pregnancy is lacking. Long-term follow-up is recommended for all infants exposed to antiretro...Common Carbohydrates May Prove To Be Substitute For Dietary Fiber
...ate beans and other legumes found thatthe bad side effects were caused by stachyose and raffinose, which now areknown to be undesirable oligosaccharrides. They're also found in soybeans.But other oligosaccharides actually may possess health-promoting properties. Instead of 15 grams of fiber a day, a person ...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...s. Pharmaceuticalresearchers can elicit biological effects by designing drugs to link upwith proteins just as natural ligands do. But in the process the drugs blockthe natural action of the protein. Toone said a "holy grail" of pharmaceutical chemistry -- theso-called "rational design"of drugs -- requi...Kids Near Airports Don't Read As Well
...nitive development and reading achievement. "These effects have all been well documented," says Evans. "Unfortunately, we're experiencing exponential increases in worldwide, ambient noise levels that are a byproduct of economic development, particularly prevalent among economically underdeveloped countries....Researchers Gain Insights Into Drugs Used For Manic-Depression
...le for thedisease, but because of undesirable side effects many people discontinueits use. In the past few years, an anticonvulsant drug prescribed forepilepsy, called valproate, was also found to be effective. Cliniciansdiscovered that best results often occurred by using a combination of bothdrugs, especia...Substance from Grapefruit Juice May Make Medications Safer
...ce in grapefruit juice that is responsible for its effects on drug metabolism. Isolating this substance could enable manufacturers to produce safer and more effective medications. One of the most interesting findings from the University of Michigan study is that, after taking grapefruit juice, CYP3A4 level...... they should tell their children about the harmful effects of drugs and alcohol. "People's concerns with teenage health issues and sex have become hopelessly jumbled," she says. "We can accept direct messages of no-alcohol and no-drug use. But when it comes to sex we rely on hidden messages. We believe that ...New Drug For Parkinson's Disease Proves Effective, Study Finds
...is surprisingly effective and may cause fewer side effects thansimilar drugs currently on the market. Patient...rding to the first large-scale study of the drug's effects on patients in the early stages of Parkinson's disease. The drug was approved last week by the ...TB Prophylaxis Unnecessary In HIV-Infected People With Anergy, Study Suggests
...uld allow many people to avoid theknown toxic side effects of INH. For example, about 2 percent of persons whotake INH develop hepatitis. The CPCRA is a network of primary care physicians and nurses who work with NIAIDstaff to design and conduct community-based clinical trials in patients with HIVdisease an...Training Urged For Mothers Of Children With Cancer
...cerCollaborative Study, who have been studying the effects of cancer on siblings. Results of their most recent study are published in the August issue ofthe Journal of Developmental and Behavioral Pediatrics. "Solving problems associated with dealing with hospital personnel,therapy protocols...NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
...ientists view the renin-angiotensin system and its effects oncardiovascular function. In 1989 they became one...n blood pressure. To further elucidate the effects of angiotensin, Bernstein, using arodent model, isolated and cloned the gene encoding the receptor f...