Tag: "elan" at medical news

Targeting mutant B-Raf protein reduces melanoma development

HERSHEY, PA- Researchers at Penn State College of Medicine have identified the mechanism by which the most mutated gene in melanoma, called v599EB-Raf, aids melanoma tumor development demonstrating its importance as a therapeutic target. ...... "Our studies suggest that using therapies to target and inhibit the function of mutant v599EB-Raf protein could prevent the spread of melanoma and halt tu...

Poverty in Northern Ireland

Senior social scientists and policy-makers meet in Belfast tomorrow (Friday, February 4) to explore how far the government is succeeding in abolishing child poverty, reducing social exclusion, and improving equal opportunities in Northern Ireland. ...... Brought together by the Economic and Social Research Council (ESRC), the UK's biggest funder of social research, the seminar will examine the di...

Article highlights confusion about Homeland Security safety symbols

SANTA MONICA, CA-- Safety symbols designed to instruct American citizens how to react if terrorists strike may confuse them, according to an article in the latest issue of Ergonomics in Design. For example, the symbol meaning "Use a whistle if one is available. Shout only as a last resort" was interpreted to mean "Yell when you hear a whistle."...... In 2002, the Department of Homeland Security (...

Scientists identify protein critical to melanoma growth

BOSTON--Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston have discovered that malignant melanoma, the potentially lethal skin cancer, can't grow without a steady supply of a protein that normal cells can do without. ...... ...In theory, such a drug would leave normal cells unharmed and have many fewer side...

Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy

HERSHEY, PA Wiping out a protein in skin cancer cells could significantly stall melanoma tumor development and increase the sensitivity of the cancer cells to chemotherapy, a Penn State College of Medicine study suggests....... The protein, Akt3, appears to be responsible for promoting tumor cell survival and development in 43 percent to 60 percent of non-inherited melanomas....... "Our study sho...

Add an 'E' to the alphabet for identifying melanoma

One more letter should be added to the alphabetic list of warning signs of melanoma, a potentially deadly skin cancer, according to a group of NYU School of Medicine dermatologists and their Australian colleagues. Based on a review of the medical literature, they recommend adding the letter "E" -- for "evolving" -- to the first four letters of the alphabet that are already used widely to help phy...

M. D. Anderson receives SPORE grant for melanoma research

HOUSTON - The University of Texas M. D. Anderson Cancer Center has been awarded by the National Cancer Institute its ninth SPORE grant - the first such grant ever awarded exclusively for melanoma research.... ...The five-year, $11.5 million Specialized Programs of Research Excellence (SPORE) grant acknowledges M. D. Anderson's leading translational research program. With the addition of the new...

Melanin makes skin vulnerable to harmful ultraviolet rays

Blondes and redheads not only are more susceptible to skin cancer, but the source of their skin and hair pigmentation, melanin, actually magnifies the damaging effects of ultraviolet (UV) rays, according to a study published online this week in the ....... Melanin filters out UV radiation, but the melanin in hair follicles, particularly in light hair, actually increases the sun damaging effects...

Cleveland stem cell investigators awarded $3.1 million

The Center for Stem Cell and Regenerative Medicine in Cleveland has received two grants totaling $3.1 million from the National Institute on Aging to study the role of stem cells in aging....... The Center for Stem Cell and Regenerative Medicine (CSCRM) is a consortium of Case Western Reserve University (Case), University Hospitals of Cleveland (UH) and The Cleveland Clinic. The two grants, to b...

Mechanism found that 'protects' aggressive melanoma from angiogenesis inhibitors

Northwestern University researchers have discovered a mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells, but not on insidious, aggressive melanoma cells that masquerade as endothelial-like cells by forming their own vascular networks, called "vasculogenic mimicry."... Mary J. C. Hendrix, professor of pediatrics at Northw...

Elan and Biogen Idec announce results from Phase III maintenance trial of Antegren

... ...NEW ORLEANS, MAY 18, 2004 Elan Corporation, plc and Biogen Idec announced that in a Phase III maintenance study, ANTEGREN (natalizumab) maintained clinical response and remission rates throughout six months among patients with Crohn's disease (CD) who had previously achieved clinical response. Additionally, a majority of natalizumab-treated patients who were also on chronic corticostero...

Zengen's new study reviews novel approach to control inflammation using melanocortin receptors

WOODLAND HILLS, Calif. (March 3, 2004) Zengen, Inc. announced today that its researchers have discovered that activation of melanocortin receptors (MCR) subtypes MC1R and MC3R could be a novel strategy to control inflammatory disorders. ... ...The findings, "Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation," appear in the March 2004 issue of Pharmacological Reviews...

Jefferson researchers find immune response, dosing keys to vaccine's success against melanoma

How well a patient's immune system reacts to his own cancer cells and the schedule by which the vaccine is given are two key factors in the success of a custom-made vaccine created from the cancer cells of patients with malignant melanoma, the deadliest form of skin cancer and fastest growing cancer in the United States. ...Nearly one-half 44 percent of malignant melanoma patients enrolled in...

Low-dose interferon fails to improve survival in high-risk melanoma patients

Alexandria, VA--A study examining the use of low-dose interferon following surgery in patients with high-risk melanoma showed no significant difference in recurrence-free or overall survival compared to patients receiving no further treatment. After more than a decade of conflicting studies on adjuvant interferon use, researchers stressed that patients and their physicians should know the facts...

Only one more case of vCJD in Ireland - probably

Only one further person from the Republic of Ireland (ROI) is likely to die from variant Creutzfeldt-Jakob disease (vCJD) as a consequence of eating BSE infected meat, say scientists. The prediction, published this week in BMC Infectious Diseases, will reassure the Irish who suffered the second highest incidence of BSE worldwide after the UK....... 1,303 positive cases of BSE have been confirmed...

Melanoma vaccine developed at the University of Virginia shows promise in clinical trial

CHARLOTTESVILLE, Va., Oct. 30 A multi-peptide vaccine to treat melanoma resulted in an immune response from 75 percent of the patients and is associated with tumor regression, according to a randomized, phase II clinical trial involving more than two dozen patients with advanced melanoma at the University of Virginia Health System. The trial also reveals what may be the most effective treatment...

Antigen targeted in therapy for melanoma also prompts immune response in brain tumor cells

LOS ANGELES (Sept. 24, 2003) A protein fragment that was previously found in melanomas has now been detected in highly aggressive brain tumors called gliomas that take the lives of about 15,000 Americans each year....... This peptide, which the immune system recognizes as an antigen, or foreign invader, appears to be a target for anti-tumor immune therapy, according to studies conducted by resea...

Study raises prospect of practical vaccine for metastatic melanoma

BOSTON--In a step toward a practical vaccine for advanced melanoma, a notoriously difficult-to-treat form of cancer, researchers at Dana-Farber Cancer Institute have demonstrated the effectiveness of a vaccine that is safer and easier to produce than earlier versions.... ...Writing in the Sept. 1 issue of the Journal of Clinical Oncology, investigators led by Dana-Farber's Glenn Dranoff, M.D., r...

T cell clones shrink melanoma tumors

Below is an advisory distributed today by the Proceedings of the National Academy of Sciences (PNAS). The paper can be found in the online early edition of PNAS at .... ...The study, conducted by Dr. Cassian Yee, a researcher at the Fred Hutchinson Cancer Research Center, involved 10 people diagnosed with advanced melanoma. For each patient immune system cells able to identify and target melano...

Researchers develop calculator to better determine prognosis for patients with melanoma

ROCHESTER, Minn. -- The following stories detail news from the current issue of Mayo Clinic Proceedings. They are intended for use as individual stories or as part of a larger story on a particular medical topic. ... ...Mayo Clinic researchers have developed another user-friendly calculator to aid physicians in better understanding complex cancer data and helping their patients make more informed...

Possible new cancer therapy shrinks tumors in melanoma patients, Science authors report

A treatment that replaces most of the body's immune system with cancer fighting cells shrank the melanomas of some seriously ill patients, researchers report. The findings appear in the journal ......The therapy takes advantage of the immune system's ability to deliver a specially targeted assault on an unwanted invader, and helps boost that assault by multiplying the number of immune cells invo...

New approach to replacing immune cells shrink tumors in patients with melanoma

A new approach to cancer treatment that replaces a patient's immune system with cancer-fighting cells can lead to tumor shrinkage, researchers report today in the journal Science*. The study demonstrates that immune cells, activated in the laboratory against patients' tumors and then administered to those patients, can attack cancer cells in the body. ......The experimental technique, known as...

CWRU/University Hospitals of Cleveland researchers investigate new cancer treatment

CLEVELAND--Biomedical engineers and physicians at Case Western Reserve University and University Hospitals of Cleveland have created an innovative drug delivery device, a biodegradable polymer rod smaller than the tip of a lead pencil, to help treat liver cancer....... "These rods serve as magic bullets, which will be inserted into a tumor in the liver using an image-guided minimally invasive pro...

Genetic manifestation of melanoma linked to geographic location

Geographic location appears to influence the probability of whether a person carrying a specific genetic mutation will develop melanoma, suggests new research published in the June 19 issue of the ...... Mutations in the CDKN2A gene are the main cause of inherited susceptibility to melanoma. Roughly 20% of tested melanoma familiesor families that have multiple cases of melanomahave this mutatio...

Interferon Alfa 2b extends overall survival and relapse-free survival in patients with high-risk melanoma, reports University of Pittsburgh-led U.S. I

. . PITTSBURGH, Oct. 16 - Interferon alfa 2b (INTRON A) unequivocally improves overall and relapse-free survival in adult patients who have surgically treated melanoma considered at high risk of recurring, according to results of a definitive study evaluating the use of this agent and comparing it with one of the best-developed anti-melanoma vaccines, GMK. Results of this National Cancer Institu...

Society for the Study of Impotence 2000 Fall Research Meeting In Cleveland September 15-17

. Latest research findings on sexual medicine to be presented . at 2000 Society for Study of Impotence Fall Research Meeting . . Approximately 200 leading experts in sexual medicine will be in Cleveland at the Downtown Marriott Hotel September 15-17 to present and discuss the latest research findings related to diagnosing and treating sexual disorders. The presentations and discussion...

New 'combination therapy' improves survival for malignant melanoma patients

.PITTSBURGH, MAY 30 -- Researchers at the University of Pittsburgh Cancer Institute announced that an immunomodulating agent, histamine dihydrochloride (Maxamine), used in combination with lower doses of interleukin-2 (IL-2), improved survival for stage-IV malignant melanoma patients compared with those treated with the same doses of IL-2 alone. The Phase III, multi-center study included 305 pa...

Genetic test for melanoma developed at UCSF

. San Francisco - A genetic test to help pathologists identify melanoma, the most. common type of skin cancer, has been developed by researchers at University of. California, San Francisco, and may be available to pathology labs within a. year.. . The test, which detects chromosomal abnormalities that characterize cancerous. skin cells, was described here, today (March 9), at the annual...

Combination immune therapy kills melanoma in mice

. August 2, 1999 -- By simultaneously stimulating the body's natural immune.response and dampening a mechanism that normally protects the body from attack.by its own immune cells, scientists have developed a promising technique for.treating the most aggressive forms of the skin cancer melanoma. The new therapy.may also work for prostate cancer. . "This two-pronged approach not only kills tumors...

National Cancer Institute awards Wistar Institute $6.6 million for melanoma research

.Philadelphia --The Wistar Institute has been awarded a $6.6 million five-year.program project grant by the National Cancer Institute (NCI) for research on.metastatic melanoma. This is the 20th consecutive year Wistar has received an.NCI program project grant for this research, directed by Wistar biologist,.Meenhard Herlyn, D.V.M. . .Wistar's melanoma research program is one of the largest in...

University Of Pittsburgh Cancer Institute Defines First Immunologic Markers Of Interferon Effectiveness Against Melanoma

.PITTSBURGH, May 17 -- For the first time, investigators have correlated the use.of interferon alfa 2b (IFNa2b) with specific immune responses in patients.treated with high doses of this agent to prevent the recurrence of melanoma. .These findings, part of a landmark multi-center study based at the University of.Pittsburgh Cancer Institute (UPCI), begin to account for the impact of.IFNa2b on rel...

Melanoma Patients' Sentinel Lymph Nodes (SLNS) Play A Strong Role In Disease Prognosis, UCSF Study Reports

.ATLANTA -- Researchers at the University of California San Francisco report that.melanoma patients whose cancer has spread to their sentinel lymph nodes (SLNs).have a greater chance of experiencing disease recurrence and mortality compared.to those whose cancer has not advanced to their SLNs.. .The sentinel lymph node (SLN) earned its name because it is the first region in.a person's body that...

Jefferson Researchers Report Progress In Using Vaccinia-Based Vaccine For Melanoma

. The concept is straightforward: beat cancer by boosting the body's.defense system. Michael Mastrangelo, M.D., and his colleagues at Jefferson.Medical College have inserted a gene for an immune-system enhancing protein into.the tumor cells of advanced melanoma patients, using the time-tested vaccinia.virus as their vaccine vehicle. . . The gene encodes granulocyte macrophage colon...

Vaccine Against Melanoma Proves Successful For Patients With Disease Spread To Two Lymph Node Areas

. A custom-made vaccine created from a patient's own cancer tumor cells.appears effective in prolonging the survival of patients with malignant.melanoma, the deadliest form of the skin cancer, spread to two lymph node areas.. . David Berd, professor of medicine at Jefferson Medical College of Thomas.Jefferson University in Philadelphia and a member of Jefferson's Kimmel Cancer.Cent...

DNA-Based Cancer Vaccine Shows Promise To Successfully Treat Melanoma In Mice

... ...New York, September 15, 1998 -- Over the past decade, knowledge about how the...immune system can be used to fight cancer has greatly increased. Not only have...scientists learned that the immune system can recognize certain proteins on...cancer cells, but they have used this knowledge to develop vaccines that may...help to prevent cancer recurrence. ... ...Now, scientists at Memorial...
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