Tag: "endostatin" at medical news
Mechanism found that 'protects' aggressive melanoma from angiogenesis inhibitors
...ersity. Hendrix and colleagues found that endostatin
and two other angiogenesis inhibitors, which preve...xperiments showed that endothelial cells have more endostatin
receptors than melanoma cells, suggesting a mechanistic basis for the differential response of the t...
Dr. Judah Folkman honored with American Heart Association/Novartis award
... among the researchers to discover a protein named endostatin
that inhibits not only blood vessel growth that no...an's lab, showed that angiogenesis inhibitors like endostatin
turn off growing endothelial cells in the fat of obese mice, causing the fat to disappear. "In all ...
First trial of endostatin shows biological activity
...- Novel laboratory and radiological analyses prove endostatin
can act against cancer, even though the agent prov... Journal of Clinical Oncology, the researchers say endostatin
shows that it can decrease blood flow to some tumors in patients and promote death in cancer and blo...
Media focus on endostatin helped -- not hurt --
...d development of an agent called recombinant human endostatin
(rh-Endo), an angiogenesis inhibitor designed to d...starving it. In the article, researchers predicted endostatin
might quickly prove to be a cure for cancer. The media blitz that followed was unusual in medical re...
New anti-angiogenic proteins discovered
... and METH-2, were shown to be much more activethan endostatin
in preventing blood vessel formation and may have ...hecornea pocket model was compared to that of both endostatin
and thrombospondin,two other human proteins. The study showed that METH-1 was most potent ininhibit...
UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
... angiostatin and the combinationof angiostatin and endostatin
prevented activation of the angiogenic switch inov... regression trial, AGM-1470 and the combination of endostatin
andangiostatin each produced significant tumor regression in mice with substantialtumors, in contras...
Inhibiting Growth Of New Blood Vessels Reduces Heart Disease Plaque In Mice
...2, compared to 0.321 mm2 for the group treatedwith endostatin
and 0.402 mm2 for the TNP-470 group. Chronic treatment witheither endostatin
or TNP-470 appeared to inhibit plaque growth by 85 percent and70 percent respectively, the researche...
UW-Madison Center One Of Two Sites Nationwide Selected For Clinical Trial Of Cancer Drug
...ns to conduct tests in humans. In animal studies, endostatin
inhibited the growth of already existing tumorsand...archers examinedthose tiny lesions, they found the endostatin
had blocked the growth of bloodvessels that nourished the tumors. Researchers also conducted tests ...
Area of Research Outlined For Promising New Cancer Drugs
The effects of angiostatin and endostatin
on mechanisms regulatingangiongenesis in other pro...ingheralded nationally this week. Angiostatin and endostatin
are being given toppriority by the National Cancer Institute and will be rushed to clinical trialin ...