Tag: "engineered" at medical news

Novel therapy tested in mice could chase away cat allergies

...nt types of allergic mice. One set was genetically engineered to have human cat-allergy cell receptors. These mice were "passively allergic" to cats: they would react to cat protein only after the scientists first injected them with human allergic antibodies to cats. When these mice were then injected with cat ...

Some brain cells 'change channels' to fine-tune the message

...s researchers studied brain cells from genetically engineered mice. Through their experiments, the researchers determined that the PICK1 and NSF proteins are both required for the calcium-forbidding channel to move into place at the synapse. Exactly how they help the channels move is still unknown, as is why th...

NHS target driven culture is failing patients

...ites. "Worryingly, it was the system increasingly engineered to medical technicians rather than to professionals that seemed to be responsible," he says. "The presiding tick box culture allowed and even fostered suboptimal assessment." Although individual clinicians did what they were asked, they did no more ...

NJIT taps into solar energy to power new campus center

...unications and networking, solar physics, advanced engineered particulate materials, nanotechnology, neural engineering and eLearning. ...

New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS

...age to increase skin permeability, the researchers engineered more than 300 new CPEs. The design of the new CPEs was based on the researchers' understanding of the molecular forces that are associated with CPE safety and potency. They then screened the new CPEs, first using computer technology and then testing ...

Researchers close in on breast cancer vaccine

... vaccine under the skin of test mice that had been engineered so that their immune systems would react to the human mammaglobin-A like a human immune system. The researchers loaded specific cells in the mice with mammaglobin-A antigens and found that the vaccine-primed T-cells attacked those loaded cells. The ...

Penn joins major NCI research initiative to advance breast cancer therapies

...chniques to analyze a series of novel, genetically engineered mouse models of breast cancer. "It's truly a multidisciplinary team effort, bringing together biologists with radiologists, nuclear chemists, physicists, pathologists, and computational biologists," says Chodosh. "This type of endeavor requires a gro...

Newly identified gene cluster on mouse X chromosome provides insights into fertility

...of the Rhox genes in male mice. They found that an engineered mouse that lacked a functioning Rhox5 gene exhibited reduced sperm production, as well as sperm motility and fertility. Wilkinson's group also found that most of the 12 Rhox genes, including Rhox5, are expressed in Sertoli cells, the "nurse" cells wi...

British conservatives should beware of Australian health service reforms

...r? The Australian prime minister, John Howard, has engineered a major expansion of private health insurance alongside a universal, publicly funded health system. Various incentives and penalties have driven coverage up from 30% to 45% of the population, but the strategy of subsidising insurance premiums has bee...

Contrary to previous findings, smoking is detrimental to patients with Alzheimer's

...he drinking water of 20 mice that were genetically engineered to develop both the plaques and the tangles of Alzheimer's disease. The researchers found that chronic nicotine exposure increased the tangles while having no significant effect on the plaques. "In contrast to previous reports that nicotine has some ...

Promise of 'bladder pacemaker' for people with spinal cord injury

... we understand the whole picture, we can pursue an engineered solution to help people restore bladder control," Boggs said. "With this new understanding of the function of the pudendal nerve and the beneficial application of both high- and low-frequency pulses in controlling bladder emptying and incontinence, i...

Researchers identify the link between heart failure and weight loss

...ss. They also demonstrate that in mice genetically engineered to overproduce IGF-1 there is a complete reversal of angiotensin-induced weight loss. The authors provide strong evidence that the signaling pathway known as the Akt/mTOR/p70S6 kinase pathway is involved in this ability of IGF-1 to prevent muscle los...

Gene vaccine protects mice against development of Her2/neu breast cancer

...rchers also worked with mice that were genetically engineered to over-express HER2/neu. These mice normally develop breast cancer in all ten of their mammary glands by the time there are 120 days old. In this experiment, they vaccinated the mice three times with VRP-neu, and "not a single mouse developed a tu...

Antibiotics protect nerves in mice by turning on genes

...elp and is safe if taken for a long time." In mice engineered to develop the equivalent of Lou Gehrig's disease, daily injections of an antibiotic called ceftriaxone, started just as symptoms tend to surface, delayed both nerve damage and symptoms and extended survival by 10 days compared to untreated animals. ...

Residual tumor cells are a barrier to targeted cancer therapeutics

...y." Chodosh concludes that the type of genetically engineered mouse models used in these MYC studies yield results that are very similar to what is observed in patients and that molecular therapies will likely need to be applied chronically to prevent the regrowth of residual tumor cells that remain after thera...

Mice with depression-like behaviors reveal possible source of human depression

...rains react to stress differently. The genetically engineered mice develop an imbalance in a hormone involved in... animal equivalent of depression." The researchers engineered mice that lose glucocorticoid receptors from their forebrains, specifically from the cortex and hipp...

Animal studies show stem cells might make biological pacemaker

...ins have found the first evidence that genetically engineered heart cells derived from human embryonic stem (ES)...on of Circulation, human ES cells were genetically engineered to make a green protein, grown in the lab and then encouraged to become heart cells. The researchers...

Blocking molecules protects health of implants

...on of CCL2 was eliminated both in mice genetically engineered without the molecule and in other mice where the function of CCL2 was blocked by means of a protein decoy via localized gene delivery. "What we found is that in the absence of CCL2 these large cells do not form at the site of the implant, therefore p...

Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth

...protein called hsFlt3L delivered via a genetically engineered virus increased the number of immune cells in the ...he tumor," commented Dr. Castro. Genetically engineered viruses are used to transport genes and/or proteins into cells and have been used in gene therapy re...

Novel drugs help solve Gleevec resistance

...ne kinases known as Src, Talpaz says. "This is an engineered drug so we know exactly how it works, but we cannot say at this point whether there are clinically meaningful differences between BMS-354825 and AMN107," he says. "Many more studies are needed to see how these drugs will perform." The bottom line, sa...

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