Tag: "engineered" at medical news

Molecular tailoring of chemotherapy with novel imaging techniques

...h ultimately kills many types of cancer cells. "We engineered a molecular beacon to detect expression of a gene called p21, that is turned on directly by p53 when cells are exposed to Doxorubicin," says El-Deiry. The cells that were exposed to Doxorubicin activated the p53-responsive molecular-beacon tag and e...

New protein 'stop sign' alters blood vessel growth

...sors Alex Kolodkin, Ph.D., and David Ginty, Ph.D., engineered a version of Sema3E that colors its binding partne...lopmental Biology Institute of Marseille in France engineered mice to lack each of the three proteins. In mice without Sema3E or plexin-D1, blood vessels along a ...

Stanford study reveals that cells linked to asthma and eczema also help cure deadly illness in mice

...ntist Mindy Tsai, DMSc, helped produce genetically engineered mast cells that could or could not respond normally to endothelin-1. The researchers could then selectively transplant these mast cells to mice that lacked the cells and thus see how it affected the ability to respond to endothelin-1 or bacterial inf...

USF neuroscientists awarded $1.1 million NIH grant to improve Alzheimer's vaccine

...this anti-CD40 ligand antibody to mice genetically engineered to develop symptoms similar to Alzheimer's disease. The mice also will be immunized with an investigational anti-Alzheimer's vaccine shown to remove beta amyloid plaques that accumulate in the brain, thereby leading to nerve damage and memory loss. ...

St. Jude scientist to lead NCI Pediatric Preclinical Testing Program

...childhood cancer xenograft lines, with genetically engineered models used when these are available and relevant to the agent being tested. The PPTP will use in vivo test panels for neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, acute lymphoblastic leukemia, renal tumors (Wilms and rhabdoid), embr...

Engineered stem cells can home in on tumors and deliver drug payload in mice

... through an intravenous injection, the millions of engineered mesenchymal progenitor cells engraft where the tum...ds," but in this study, they looked at whether MSC engineered to carry interferon beta could treat mice that were implanted with human breast cancer or human mela...

Fetal tissue restores lost sight

...transplanting retinal sheets from pigs genetically engineered to reduce the chances of immune rejection....

Researchers identify brain protein that halts progression of Alzheimer's

...t of transthyretin while studying mice genetically engineered with defective genes taken from human patients with early-onset Alzheimer's disease. As expected, the defective genes produced mice with higher-than-normal levels of the toxic beta-amyloid protein. These mice did not, however, exhibit symptoms of Alz...

New hope for ALS seen with genetic techniques, growth factors

...hibit SOD1 mutant gene expression, the researchers engineered a virus to deliver molecular instructions that act...ht give the neurons an advantage. They genetically engineered mice that had ALS and expressed the VEGF receptor in greater numbers than normal. "Overexpression of...

Olfactory bulb stem cells and Lou Gehrig's disease

... transplanted into the spinal cords of genetically engineered mice that develop the equivalent of ALS. Animals that got the transplanted cells did develop disease symptoms, but did so about a month and a half later than non-transplanted animals (137 days versus 90 days of age, on average). Treated mice also liv...

Cedars-Sinai October 2004 medical tipsheet

...Hedgehog" and Gli-1" - delivered via a genetically engineered virus into the brains of laboratory rats, presented the progressive degeneration of nerve cells in the brain that cause Parkinson's disease. The study, published in the September issue of the journal, Molecular Therapy, may lead to a new way to trea...

Melanin makes skin vulnerable to harmful ultraviolet rays

...he melanin," he said. Brash's laboratory used mice engineered with pigmentation for yellow or black hair, as well as albino mice with no pigment at all. The researchers then irradiated the mice with UV rays that are about the same as what breaks through the ozone layer, affecting humans. The cell death was con...

Gene from 1918 virus proves key to virulent influenza

...niversity of Tokyo, describes experiments in which engineered viruses were made more potent by the addition of a...tinin and neuraminidase and infected mice with the engineered viruses. "Here we demonstrate that the [hemagglutinin] of the 1918 virus confers enhanced pathogenic...

'Hedgehog' signal distinguishes lethal from localized prostate cancers

...dgehog's role in metastasis, Karhadkar genetically engineered normal prostate cells to activate their Hedgehog signal. These cells then grew unchecked and formed aggressive tumors when implanted into mice, he found. He also discovered that triggering Hedgehog activity in a low-metastasizing rat prostate cancer ...

Lab studies show two proteins prevented progressive nerve cell loss in Parkinson's disease

...Hedgehog" and "Gli-1" delivered via a genetically engineered virus into the brains of laboratory rats, prevente...he disease from progressing, we used a genetically engineered viral vector to deliver very specific molecules to see whether they would prevent the nerve cells in...

How a dietary supplement can protect against Alzheimer's disease

...acid docosahexaenoic acid (DHA) on transgenic mice engineered to have the human version of a mutant amyloid precursor protein (APP)--the source of the brain-clogging protein in Alzheimer's disease. The researchers' analyses revealed that such animals showed particular vulnerability to damage to structural prote...

Needle-free anthrax vaccine shows promise in animal studies

...ered formulation of the rPA antigen, a genetically engineered protein, is also more stable than the liquid version and can withstand wider temperature extremes, allowing it to be stockpiled for longer periods and in more extreme conditions without the need for refrigeration, the researchers say. Conventional an...

New imaging technique may help reduce risk of heart attacks, strokes

...ys. For these initial tests the Massachusetts team engineered a plaque mimic from a gel of soluble connective tissue. When the gel was bathed with MPO, the magnetic probe generated up to a two-fold increase in MRI signal. That jump was enough to generate easy-to-spot white areas on the MRI image. The group, whi...

OHSU vaccine and gene therapy institute receives $3.5 million for AIDS vaccine research

...he smallpox vaccine virus (vaccinia) or adenovirus engineered to produce HIV proteins. Both of these vectors can...uals and generate immune responses to new proteins engineered into the vector. To develop and test this vaccine method, scientists will study animals at OHSU's Or...

Immune cells may play important role in progression of type 1 diabetes, Joslin researchers find

...oston looked at two related strains of genetically engineered mice -- one whose insulitis is known to be destructive and the other whose insulitis is innocuous. Using powerful genetic tools known as microarrays, which allow the researchers to test for thousands of genes at once, they looked for differences in g...

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