Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
...irectly to the leukemia cells. The antibody is engineered to carry just a few molecules of a new and extremelypotent chemotherapy agent - from the calicheamicin family -- to selectivelydestroy leukemic blast cells. This approach may spare primary and vital bonemarrow cells that are responsible for regenera...Substance Discovered That Induces Hair Follicle Formation In The Mature Skin Cells Of Mice
... places where it has been lost. The genetically engineered mice were exceptionally hairy. In some mice, most... Unlike in embryogenesis, however, the genetically engineered skin of the transgenic mice made an endless supply of beta-catenin and benign follicle tumors formed...... on a commercial scale. CropTech has genetically engineered tobacco plants so far grown only in greenhouses. The genes inserted into the tobacco DNA orders the production of human enzymes, which can be extracted, purified and used to develop pharmaceuticals. The gene that produces the protein cannot be "tur...Study Shows Potential For Quelling AIDS Nerve Pain
...-related sensory neuropathy to evaluategenetically engineered nerve growth factor as a treatment. Nerve growth factor(NGF), found naturally in the body, is a small, potent molecule that helpsmaintain certain nerve cells. It also prods those nerve cells to grow and to communicate with other cells. In t...University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence
...d into theirbody. Researchers hope the genetically engineered cells will rev up the patient'simmune system to seek and destroy any remaining cancer cells. The procedure should be almost completely nontoxic, Jordan said. It wouldeliminate a second round of chemotherapy for patients, reduce their exposure totoxi...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
... the company cautioned. ONYX-015 is a genetically engineered adenovirus that, in prior preclinical andclinical studies, has been shown to replicate in and kill tumor cells deficientin p53 tumor suppressor gene activity. Mutations in p53 are the most common typeof genetic abnormality in cancer, occurring in mor...Successful Cancer Therapy May Doom Later Treatments To Failure
... their cancer-killing powers because they havebeen engineered too large for the microscopic doors they have to pass through. Equally perplexing, some chemotherapies lose their efficacy after only a fewrounds. Many have chalked up these failures to the development ofresistance -- when successive rounds ......t BNP7787, a novel water soluble disulfidethat was engineered to increase the therapeutic index of cisplatin andcarboplatin, two widely used anticancer drugs. Although platinum chemotherapy is widespread, formulations of cisplatin andcarboplatin have a major risk of kidney toxicity (cisplatin), nausea andvomit...Researchers Finding May Boost Effectiveness Of Anti-HIV Drugs
...ease inhibitors into mice thathad been genetically engineered not to express Pgp, brain levels of the drugsclimbed to seven-to-40 times higher than in mice that normally express PGP. The researchers also found that brain levels of the protease inhibitorsin normal mice were about one-tenth the blood leve......al. The Duke clinicaltrial will test a genetically engineered form of the enzyme, expressed ina cell line developed in the laboratory of Dr. Y.T. Chen, chief of the Divisionof Medical Genetics in the department of pediatrics. Initially, the drug will be tested in a small number of Pompe diseaseinfants to evalu...