All chronic sinusitis is not created equal, study finds
... the MCG Section of Anatomic Pathology, to include eosinophil levels on pathology reports for sinusitis patients at MCG Medical Center, a step that could also be taken by other hospitals. The ability to better categorize this common condition is a good first step in more targeted treatment; for example, patient...American Thoracic Society Journal news tips for February 2004 (second issue)
...t ran 88 percent, along with 86 percent for sputum eosinophil analysis. (Exhaled nitric oxide increases in patients with bronchial asthma.) Overall, the diagnostic accuracy of the exhaled nitric oxide and sputum analysis was significantly greater. The investigators noted that it is much more logical to use ex...Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome
... treatment of asthma, anti-IL-5 therapy blocks the eosinophil growth factor interleukin-5 (IL-5). IL-5 is a cyto...as well tolerated in all four patients and lowered eosinophil counts despite on-going systemic steroid therapy. This decline in eosinophil counts was sustained fo...White blood cell plays key role in body's excessive repair response to asthma
...L5, which removes Interleukin-5, a key molecule in eosinophil development, was given to mild asthmatics as part of a randomised, double blind, placebo controlled protocol. The 24 patients in the study received three infusions of either the antibody or a placebo dummy injection one month apart, and had a biopsy ...American Thoracic Society Journal news tips for June 2003 (second issue)
...oids did not significantly reduce peripheral blood eosinophil levels. (Eosinophils, a type of white blood cell, normally constitute from 1 to 3 percent of the total white blood cell count. Elevated levels of activated eosinophils are believed to play a key role in the pathophysiology of asthma and rhinitis.) ......sages at two weeks. They also had lower levels of eosinophil cationic protein, another sign of inflammation. Side effects were minimal. Five of the 29 people on fluticasone and six of 31 on loratadine and montelukast complained of headache. "Our study supports the addition of the combination of montelukast an......-DNA inhibited both airway hyperresponsiveness and eosinophil infiltration byexerting a significant inhibitory effect on the generation of eosinophil-activecytokines (IL-5, GM-CSF and IL-3). Moreover, while both ISS-DNA andcorticosteroids inhibited IL-5 generation, only ISS-DNA was able to induceIFN-g, a cytoki...