Tag: "evade" at medical news

Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression

...substance in the body that enables cancer cells to evade surveillance by the body's immune system. The immunosuppressive effect of TGF-beta in cancer progression is well established. After inserting a mutated form of the TGF-beta receptor into CD8+ T cells, Lee and associates transplanted the tumor-specif...

Small increases or 'blips' in HIV levels do not signal mutations leading to drug-resistant HIV

...t of virus could indicate the virus had mutated to evade anti-viral drugs being taken. Instead, the Hopkins team has shown that these so-called blips are mathematical artifacts, or variations, that stem from the test used to gauge the amount of virus in the body, a measurement known as viral load. Accord...

NIAID launches influenza genome sequencing project

...ergo continual genetic changes that enable them to evade the body's immune response and sometimes become more virulent," says Anthony S. Fauci, M.D., director of NIAID. "This project not only provides a valuable resource for current influenza researchers, it also will attract investigators from other field...

Promise of stem cells amplified

...yder. "They are inevitably lethal because they can evade even the most extensive surgical excision and therapies. Neural stem cells are uniquely poised to treat tumors because the cells are attracted to areas of abnormality." The researchers used genetic engineering to turn the cells into delivery vehicle...

Stanford scientists help bring study of smallpox virus into 'molecular age'

...in general about the strategies used by viruses to evade and subvert host defenses, as well as provide new insights into the workings of the human immune system." ...

OHSU vaccine and gene therapy institute receives $3.5 million for AIDS vaccine research

...ntered by vaccines, HIV is very robust and able to evade most immune responses," explained Picker. "One theory about why the AIDS vaccines developed so far have not been entirely effective is because they provide only a brief period of time for the anti-HIV immune response to develop, perhaps compromising ...

Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research

... be devious in that it does everything possible to evade destruction. But viruses are equally tricky in their quest to invade cells and propagate." Now, Delta-24-RGD is expected to start the first phase of human testing in late summer 2004, with a two-staged clinical trial of 15 patients each. One stage wi...

Study finds HIV protein can drive immune cells away

...which pathogens can repel immune cells and thereby evade the immune system. In 2000, Poznansky and colleagues published a report that found how a protein called SDF-1, known to attract immune cells, can actually repel T cells when present in elevated quantities. SDF-1 is a chemokine, a protein normally ...

HIV: A sugar shield to evade host defences

... by the virus of extremely large complex sugars to evade the host's immune system. These sugars fix on to the glycosylation sites, creating a spatial mask, and prevent the antibodies from binding to the virus recognition sites. Selection pressure by the immune system acts on these sites. They appear to ch...

Sounds of New York, evidence for a preferred ear, ultrasound for the eye

...ds of mines, including the small plastic ones that evade metal detectors. In general, the acoustic systems generate small seismic waves, which gently shake small areas of the ground and then use lasers or radar beams to detect the distinct vibrations of ground containing buried landmines. Many leading dev...

Adaptive regulatory T cells suppress killing of persistently infected cells

...viral therapeutics. Many human viruses are able to evade the immune system during acute infection and establish long-term persistent infections that are extremely difficult to eliminate. Most of the time, proliferation of the virus is balanced by antiviral immunity and the host experiences little to no dam...

Experimental drugs show promise in halting brain tumors

...on, blood vessel growth and the tumor's ability to evade the immune system. By blocking the activity of the TGF-beta receptor, SB431542 also inhibited the expression of another critical protein in the cell called PAI-1. This protein, which normally communicates with TGF-beta in cancer cells, is a predictor...

Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system

...understanding the mechanisms that enable tumors to evade destruction by the immune system. This gives us ne...hat Fas ligand contributes to a tumor's ability to evade the immune system. Taken together, the studies indicate that malignant brain tumors are protected ag...

Smart virus eliminates brain cancer in animal experiments

... be devious in that it does everything possible to evade destruction. But viruses are equally tricky in their quest to invade cells and propagate." "In this experimental war between cancer and a viral therapy, the virus won," Lang says. "Of course, we hope to obtain similar results when patients are tested...

New role for immune system player may help improve cancer vaccines

...he adaptive immune response combats pathogens that evade the body's initial defense mechanisms. Unlike innate immunity, the adaptive immune system develops specifically in response to an infection, changing as needed to ward off each invader. "This link between the innate and adaptive immune systems is im...

Case study highlights importance of early detection of testicular cancer

.... Some men with large testicular lumps continue to evade the medical profession despite all efforts. The 17-year-old man in the Case report may have contributed to his own death by not seeking medical advice earlier...Medical professionals and the general population, especially men, need to be educated to ...

War on bacteria could leave drug-resistant strains unchecked

...nd strokes. Because many bacteria have learned to evade some or all of the 100 or so antibiotics developed in the last 60 years to fight them, deaths from infectious diseases like tuberculosis are once again on the rise. So concerned are leaders of the World Health Organization, American College of Physi...

Seattle researchers uncover structure of blood-clotting protein involved in most common form of hemophilia

...ically tweaked human factor VIII, each designed to evade the immune response while still allowing the protein to do its clotting job. "Now that we have the structure, we can identify every amino acid on the surface of the protein that potentially could be mutated in the laboratory. In theory, we could make...

Scientist show how viruses co-opt cell defenses to cause chronic infections likethose from HIV and Hepatitis B and C

...r level how viruses like HIV and Hepatitis B and C evade andco-opt the defense strategies of the cells they invade to cause chronicinfections. In a study reported in the Proceedings of the National Academy of Sciences, agroup led by Allan Lau, and Michael Yeung, scientists in the Department OfPediatrics a...

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