Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...s that leptinis only the first step in a series of events that ultimately boosts fatmetabolism, according to...it inside the cell.The signal initiates a chain of events that results in the burning of storedfat. Specifically, mice on a high-fat diet that received the ...Fertilization Protein Structure To AID in Leukemia Treatment
... the process of fertilization. The details of the events that occur at the molecular level when a sperm cel...al kingdom, including in humans. One of the first events is that a flood of calcium ions is released as a signal tothe egg to prepare to begin dividing. The...KUMC Researchers Announce Breakthrough Method For Predicting Epileptic Seizures
... infection, poisoning, oxygen deprivation or other events that cause scarring in the brain. This scarring acts as an irritant to the nerve cells which can trigger an abnormal electrical discharge, causing a seizure. For patients with epilepsy, the implications of being able to reliably predict the o...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...lfred P. Sloan Foundation. Molecular binding events control many biological processes within ourbodies...akes place withincells. And blocking these binding events using synthetic molecules is thebasis of action of almost all pharmaceutical compounds, Toone said. ......do have reason to think our system can find subtle events thatmay be captured in future high resolution systems," Barnes added. The system also might help radiologists reduce eye fatigue, increaseproductivity and possibly increase patient loads. Partially developed with internal funding from GTRI, the sys...Stress: It's Not Just All In Your Head; Scientists Map The Wear And Tear Of Daily Life
...more important than how we feel about thestressful events in our lives is how our bodies react in terms of the stresshormones they produce." Stressful life events - whether the loss of a loved one, divorce orjob loss - as well as the daily wear and tear of living...Heart Attack Survivors Can Lower Stroke Risk By Taking Cholesterol-Lowering Drug, Study Says
...se," Plehn says. "We looked athundreds of reported events to verify that they had indeed been strokes and notmigraine headaches or something else that might appear to be strokes." This work revealed that 128 CARE participants (52 taking pravastatin and76 on placebo) suffered confirmed strokes durin...Snipping Inflammation In The Bud; New Agents May Provide Relief
...r-the-counter drugs such as ibuprofen, is to block events inside the cell.The synthetic molecules in Kiessling's approach act as inhibitors on the outsideof the cell, attaching themselves to aL-selectin proteins and preventing the cell from linking with an opposing cell. But synthetic molecules that only in...Diuretics And Beta-Blockers Are Best Drugs To Combat High Blood Pressure, Study Finds
...rt attacks or strokes? We think these catastrophic events are closely associated with decrease in blood pressure, but we want to be sure," says Perry....Clinical Pharmacists Improve Outcomes Of Heart Failure Patients
...of drugs which is very important in reducingfuture events and deaths for heart failure patients, Gattis said. "Clinical pharmacists have been extremely helpful -- both for physiciansand patients -- in evaluating the side effects of drugs and their interactionswith each other," O'Connor said. ...... Most large clinical trials use clinical events committees (CEC) toreview case records to ensure that all the physicians at participating hospitalsfollow the same guidelines. CECs are usually composed of cardiology fellows andattending cardiologists and their rulings are final. Differe...Studies Look At Threshold Effect Of Cholesterol-Lowering "Statin" Drugs
...n in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study," a... treatment with pravastatin and recurrent coronary events in the Cholesterol and Recurrent Events Trial," are Lemuel A. Moye, M.D., Ph.D.; Barry R. Davis, M.D...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
.... These similarities in the molecular events underlying learning and memory and those operating during synaptogenesis are consistent with studies showing that experience modifies neuronal circuitries both during development and in adulthood....Area of Research Outlined For Promising New Cancer Drugs
...uations, such as cancer, angiogenesisis needed for events such as embryogenesis, wound repair, and successful skingrafts. "It's important to remember that cancer patients are sick," heexplains. "There are other pathologies besides tumors. Many such patientsexperience difficulties with clotting, bleeding...Cost-Effective Treatment Possible In Africa For HIV-Positive Pregnant Women If Drug Prices Lowered
...rial world prices, according to Marseille. "These events open the way forlarge-scale drug interventions because we now know that these therapies can makeboth medical and economic sense," he said. The research findings are reported in the May issue of AIDS. Co-investigatorsare James G. Kahn, MD, MPH, UCSF ...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...nvolve a numberof risks and uncertainties. Actual events may differ from thecompany's expectations.In addition to the matters described in this pressrelease, the timeline for clinical activity, results of pending or futureclinical trials, including the trials of ONYX-015, and changes in the status ofthe co...National Office Of Drug Safety Is Needed, Experts Say In JAMA
... The FDA estimates that only 1 percent of adverse events are everreported. For example, an average of 82 adverse reactions are reported each yearfor digoxin toxicity, which includes serious arrhythmias, but a systematicstudy of Medicare records found 202,211 hospitalizations in a seven-year periodfor digo...Pioneer In Nuclear Medicine Wins Lifetime Award
... In the 1960s, Wagner wanted to track biochemical events as they occurredwithin the living body, but the most widely used isotope at the time,reactor-bred Carbon 14, emitted energy that was not powerful enough to escapethe human body, and so was of no use in his work. (Carbon 14's long half lifeallowed res...Drug Combination Including New "Super Aspirin" Drug Cuts Risk Of Death Or Second Heart Attack
...ut there's more than a 50percent increase in these events between 30 days and six months, regardless ofcurrent therapy." The study involved 2,282 hospitalized patients in 20 countries. Patients were assigned one of the following drug combinations: low-doselamifiban with or without heparin, high-dose...Study Captures Images Of Memories Being Formed Within The Human Brain
...ing PET technology can now be captured by fMRI for events as brief as30 milliseconds. "The split-second thoughts that people have about incoming informationplay a huge role in whether that experience will be remembered or forgotten,something that happens in a second can have consequences for the res...