MetaPhore Pharmaceuticals initiates Phase I clinical trial of enzyme mimetic compound for oncology
...apies such as IL-2. By selectively catalyzing the excessive superoxide in cancer states, the enzyme mimetic ap...ddress the diseases and conditions associated with excessive superoxide production. In preclinical models, the primary drug candidates from this family of comp...Highest known catalytic rate for superoxide dismutation achieved
...address the diseases and conditions resulting from excessive superoxide production. In pre-clinical models, the lead candidate from this family has suggested the potential to combat such diseases and conditions more effectively and with fewer side effects than existing treatments. SOD enzyme mimetics have...License agreement signed to commercialize intelligent hearing aid
...e wearer to focus on a single conversation without excessive interference, the intelligent hearing aid will represent a significant improvement over conventional systems, Feng said. The intelligent hearing aid prototype consists of a pair of miniature microphones, a processor, an amplifier and two earpieces. ...Animal studies indicate new approach for treating end-stage skin and kidney cancers
...address the diseases and conditions resulting from excessive superoxide production. In pre-clinical models, the lead candidate from this family has suggested the potential to combat such diseases and conditions more effectively and with fewer side effects than existing treatments. Synthetic SOD enzymes hav...UNC study ties depression, anxiety to fatigue in HIV-positive patients
...ssion and anxiety -- are responsible for patients' excessive tiredness. Other contributors, researchers found, appear to be lower than normal amounts of hemoglobin, the complex molecule that carries oxygen to tissues; lower than normal hematocrit, which indicates the proportion of cells and fluids in the b...Study: Drinking in fraternities, sororities doesn't necessarily continue after college
...ecreases as a result." Effective prevention of excessive alcohol consumption on campus involves efforts with clear alcohol policies, consistent enforcement of those policies and coordination with prevention efforts in the larger community surrounding the campus, they wrote. "There also needs to be appr...Mouse provides clues about chronic pain
...lutamate AMPA and kainate receptors. However, when excessive information reaches these synapses between nerve cells, normally-dormant NMDA receptors can be activated, and a series of intracellular signaling molecules can be triggered. This cascade of events leads to long-lasting changes in the way neurons comm...VA trial to weigh aspirin against other anti-clotting drugs in heart disease patients
...eeds to make clotting proteins. It also can cause excessive bleeding, so patients require close monitoring and frequent blood tests. Aspirin and clopidogrel both work against platelets, blood cells that stick together and encourage clotting. Aspirin helps prevent platelets from clumping together. Clopidogr......ctors. As a consequence many patients suffer from excessive daytime sleepiness, impaired cognitive ability and...disturbance, insomnia and its implications such as excessive daytime sleepiness are a major cause of morbidity and impaired quality of life for patients with PD.......itution. Symptoms of psychotic agitation included excessive excitement, hostility, poor impulse control and delusional behavior. The degree of agitation experienced by the patients, and the improvement demonstrated following treatment, was assessed using the Positive and Negative Syndrome Scale (PANSS) and...Selective inhibitor can target specific enzyme that promotes cancer
... natural inhibitor in the human body that prevents excessive MMP activity, he said. The new molecule is designed to only fit the gelatinase enzyme, and through its design, initiate a reaction that stops the harmful activity, Mobashery said. Researchers have been aware of MMPs for nearly three decades. There ar...University of Rochester awarded patent for class of drugs known as cox-2 inhibitors
...vely blocking cox-2 also block cox-1, resulting in excessive production of stomach acid as well as ulceration and gastrointestinal bleeding. These and other side effects of aspirin and other NSAIDs caused 76,000 people to be hospitalized in 1998 and resulted in 16,500 deaths. Young and his colleagues at t...Rush conducts nationwide study to find genetic markers for depression
..., feeling guilty or worthless, irritability and/or excessive crying. Those with the illness may experience episodes consisting of three or four of the above symptoms nearly every day for two weeks or more. Rush is seeking individuals and siblings with symptoms of major depression for this research study. T...Study finds some bottled water has more bacteria and less fluoride than tap water
...uld not get supplementary fluoride. That's because excessive ingestion of fluoride during childhood can cause fluorosis, a demineralization of the dental enamel that may result in discolored teeth. Manufacturers are not required to include fluoride levels on their labels, but the researchers believe they shou...Teasing out the early steps of neurodegeneration
...he mice were born with a SCA1 gene containing an excessive number of glutamine repeats and suffered Purkinje cell degeneration. Using a technique known as "PCR-based cDNA subtraction," which allowed them to compare gene expression in normal and SCA1 mice, Zoghbi and colleagues were able to pinpoint other ...New web site provides access to information on sleep and sleep disorders
...tance of obtaining adequate sleep and the risks of excessive sleepiness," said NCSDR Director Dr. James Kiley. "Our new Web site provides information that will help the public and health care professionals recognize the signs of common sleep disorders and the need for professional treatment. It will also enc...Work overcommitment impacts the heart
...system. An imbalance in these systems can lead to excessive clot formation and subsequent atherosclerosis and cardiovascular disease....Studies of growth hormone result in new class of drugs
...inhibit growth hormone activity in scenarios where excessive growth hormone action may be implicated in a disease," said Kopchick, who added that his work and studies elsewhere suggest growth hormone is involved in the progression of diabetic kidney disease and breast cancer. His research team now is conductin...Visionary physician pioneers alternative clubfoot treatment
...ies who could be treated in such a way as to avoid excessive surgery. I began using Dr. Ponseti's method two and half years ago. My only regret is that I didn't learn this technique earlier." As part of his effort to promote the technique, Ponseti will conduct teaching clinics at the University of California...Abstemious mice offer hint at molecular target for treating alcoholism
...ve to be atarget for reducing the craving for, and excessive use of, alcohol - a hallmarkof alcoholism. In the November issue of Nature Neuroscience, they report that mice geneticallyengineered to lack the enzyme, known as PKCe, were 75 percent less apt toimbibe than their normal brethren. Mice lacking the en...