Discovery Hints At Multitude Of New Targets For Drugs
...t." McDonnell uses a geometric analogy to explain how a single kind of steroidreceptor found throughout the body can produce such different effects indifferent tissues by assuming different conformations. "Let's say a receptor needs to be in a 'square' conformation to produceall the process...What Makes Tics Tick? Clues Found In Tourette Twins' Caudates
... receptor availability in one small area appear to explain rather large differences in clinical presentation, say the researchers. Functional brain imaging studies of OCD (obsessive compulsive disorder), which often occurs along with Tourette Syndrome, also implicate a brain circuit that includes the head ...UNC-CH Study Shows State Protects HMO Clients Poorly
...r the services medically necessary, but they never explain the criteria they use in deciding what's necessary...age -- the handbooks for enrollees -- which should explain covered benefits and exclusions sometimes were incomplete and often confusing, she said. Plans used ...Researchers Gain Insights Into Drugs Used For Manic-Depression
...nhanced effect. "This additive effect may explain the clinical observation that insome patients the use of the two drugs together can produce the bestresults," he said....... frankly what our family values about sex are, and explain why we don't want them to have sex too soon. These messages are not contradictory."...Study Injects New Interest In How Vaccines Work
..." Though he does not have an alternative theory to explain how aluminum hydroxide works to boost antibody production, Hem says that his study may spur new interest into the mechanism behind this reaction. "The study also explains why aluminum hydroxide adjuvants have such a good safety record," Hem says. "Th...Mother's Milk: Nutrition And Nurture For Infants -- And The Best Defense Against Disease
...se of formula-fed babies.One proposed mechanism to explain this observation is that certain antibodies inbreast milk may mimic bacterial and viral proteins. Such mimicry would have theeffect of priming the infant immune system to respond more vigorously when laterexposed to actual pathogen proteins. ...3D Ultrasound Gives Better View Of Brain's Arteries
...onal (2D) ultrasound,researchers from Germany will explain on August 14th in a presentation at the InternationalNeurosonology '97 conference sponsored by the World Federation of Neurology andthe Bowman Gray School of Medicine of Wake Forest University. According to Dr. Andreas Delcker, the lead resea...Many Medical Screening Tests May Be Unnecessary.
...ysicians can use a 'preventive ethics' approach to explain that tests with controversial benefits are unlikely to be helpful." The lead author, David J. Doukas , M.D., is an associate professor in the U-M Department of Family Practice and associate director for clinical bioethics in the U-M Program in S...'Bathtub' Equation Aids Diabetes Research
...nd bathtubs better than beta cells." Finegood will explain her research at the first lecture in the fallpresident's lecture series on Wednesday, Oct. 29 at 4:30 p.m. in the HalpernCentre. Finegood didn't start out studying diabetes because of an interest in thedisease. "I was interested in applying engineeri...Natural Estrogens May Help Protect Women From Brain Damage During Stroke
...d critical care medicine at Hopkins. "It may also explain thesteep rise in strokeincidence in women after menopause." The researchers created strokes in anesthetized male and female rats byblocking blood flow for twohours through the middle cerebral artery, a brain blood vessel commonly linkedto cerebr...Researchers Finding May Boost Effectiveness Of Anti-HIV Drugs
...ation of thechemicals it recognizes. That may help explain why the blood levels of proteaseinhibitors, despit...rug from getting intothe bloodstream, and that may explain some of the drug failures." Pgp is also expressed in the blood vessels lining the brain, kno...Bi-Monthly Boosts Of Aspirin Benefit Heart
...on. "This red blood cell-platelet interaction may explain why manyindividuals respond to aspirin in a less than optimal fashion," says Marcus. But in their study, researchers found that a single 300-mg dose ofaspirin could initially "neutralize" the platelet stimulatory activity of thered bl...Added Benefit Found For Aspirin Use In Patients With Vessel Disease
...thesda, MD. They add that these findingscan partly explain why aspirin has beneficial effects on the rate of heartattacks as proven in other studies. Contact: Dr. Arshed Quyyumi can be reached at (301) 496-5817....Drug's Effect On Chromosomes May Explain Second Cancers
...elomere, new research shows. The finding may help explain a serious after-effect of the drug -- ina small number of patients, it gives rise to often-fatal, secondary cancers. The drug, etoposide, is used in the treatment of leukemia, lymphoma,and testicular cancer. It is also used experimentally in a numbe...Unhealthy Lifestyles Not Primary Cause Of High Mortality Rates
...valence of health risk behaviors, however, did not explain the higher rate of age-adjusted mortality among those with lower incomes. "After taking baseline health status and personal health behaviors into account, we found that people with lower incomes still had a much higher risk of dying," Lantz said. ...Health Risk To "Cigarette Babies" Is Neglected, Duke Scientist Charges
...ecific nerve pathways. "Such effects might explain why nicotine is often more viciouslyaddictive in adolescents than it is in adults, and why the adolescent smokerbecomes the lifelong smoker." Slotkin also asserted that the worldwide increase in smoking willeclipse AIDS in the death and socie...Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure
... June 19 -- Response to a stress chemical may help explain racialdifferences in the prevalence of high blood pressure, according to a report inthis month's Hypertension: Journal of the American Heart Association. In a study of blood flow in people during mentally stressful conditions, JulioA. Panza, M.D., an...New Study Indicates Lightning Can Kill Without Leaving a Mark
..." said Wachtel. "We think thishypothesis may help explain some of these occurrences." Lightning can kill at any altitude, the researchers stressed. In onecase cited by the authors in Lancet, a foursome of golfers standing under a treethat was struck by lightning. One golfer sustained burns, two we......DNA and RNA PCR(polymerase chain reaction) help to explain how the genital tract can have highlevels of HIV replication even when the virus is not readily detected in theblood. Media Contacts: Kenneth Mayer 401-729-2776 kenneth_mayer@brown.edu...