Other highlights in the September 18 issue of JNCI
...f normal and malignant human urothelial cells that express CD40. They found that the apoptotic responses of the cells to CD40 ligation depended on how CD40L was presented to the cells, suggesting that susceptibility to CD40 ligation-induced apoptosis may be a useful therapeutic approach for eliminating malig...Pituitary tumor cells in Cushings syndrome found to express large amounts of protein receptor
...ai Medical Center have found that pituitary tumors express an abundance of a specific protein receptor and report that treatment with a common diabetes drug was effective in shrinking tumor size and reducing hormone production in Cushing's pituitary tumors in mice. The findings, reported in the November iss...Study finds more satisfaction in same-race doctor-patient relationships
...d to determine if it was indeed true that patients express greater satisfaction if they have a physician of the same race group." Previous studies have found that patients who are satisfied with their physicians were more likely to keep follow-up appointments and comply with a prescribed medical regimen and ...Cholesterol drug could lead to new therapy for multiple sclerosis
...examined a model of mice genetically engineered to express a receptor on their CD4+ T cells that caused the cells to recognize and latch on to the MHC Class II molecule complex with brain antigen on B cells and macrophages. This recognition in turn provoked the CD4+ T cells to incite the inflammatory respons...Targeting bone metastasis and hypercalcemia
...etabolism. Most breast cancers that spread to bone express high levels of parathyroid hormone related protein, or PTHrP, a molecule that promotes bone breakdown. Scientists believe that the bone breakdown caused by PTHrP starts a vicious cycle: cross-talk between the tumor cells and the osteoclasts, cells th...Nabi Biopharm's nicotine vaccine
...the United States, and while 80 percent of smokers express a desire to quit smoking, fewer than 10 percent of those who try, succeed in quitting for more than six months. Thus, we believe this product has the potential to meet a major healthcare need." The NicVAX patent specifically covers the composition ...Why Britain's gay, lesbian and bisexual Muslims need dedicated support groups
...nd permissiveness, they told the research team. To express their sexuality was not merely to defile their own moral character but the religious and cultural purity of the entire community. Whilst some did not consider themselves practising Muslims, most accepted the importance of Islam in their lives. The wo...Malaria project in funding crisis
... by donors, and audits by the RBM. Theauthors also express concerns that what little money is beingdonated is not being spent in the countries that need it most. Malaria is second only to HIV/AIDS of the infectious diseasesclaiming lives globally. 90% of cases occur in Africa where 1million people die from m...Russell Berrie Foundation gift to Columbia University propels diabetes treatment into new era
...e. The Russell Berrie Foundation was created to express the values, passions and ideas of Mr. Berrie, whose interest in diabetes was quite personal. He had Type 2 diabetes, and, through a large gift in 1997, created the Naomi Berrie Diabetes Center at Columbia University. The Berrie Center, named for Mr. ...Chemical turns stem cells into neurons say scientists at Scripps Research Institute
... were induced to become neurons, the neurons would express luciferase--which can convert a non-luminescent substrate to a luminescent product. This product makes that well easy to detect from tens of thousands of other wells with GNF's state-of-the-art high-throughput screening equipment. Once they found som...Scientists develop technique that uses ultrafast lasers to obtain hi-quality images of brain tissue
...e to the rest of the brain. Images of brains that express a particular fluorescent protein could also be used to quantify how much of that protein there is in different regions of the brain. This technique is not limited to the brain, either. Other tissues in the body could be imaged with the femtosecond l...UIC researchers pinpoint genes involved in cancer growth
... vector, or delivery vehicle, and inducing them to express their genetic information. Some of the fragments prove to be biologically active by interfering with the function of the genes from which they are derived. In the new study, certain fragments inhibited the multiplication of breast cancer cells by sh......experienced tragedy. Doctors' enhanced ability to express their own emotions has proven benefits for patient and doctor. Previous studies cited by Dr. Kasman in her paper have shown that doctors can avoid burnout and negativity by effectively expressing their feelings about work. Another study showed a di...JCI table of contents, 1 August 2003
...hey also found that CB1 is present on neurons that express peptides known to regulate food intake, suggesting that endocannabinoids may directly alter appetite-regulating signaling pathways in the brain. They also demonstrate that the CB1 receptor is also present in fat cells and may affect the breakdown of ...Other highlights in the August 20 issue of JNCI
...treatment than similarly treated mice that did not express CYP12A. The authors conclude that either CYP1A2 is not the major metabolic activator of ABP or that other enzymes metabolically activate ABP. Contact: Dama Kimmon, University of Cincinnati Medical Center, 513-558-4553, dama.kimmon@uc.edu . New Ana...UCLA scientists invent search-and-destroy method to flush HIV out of hiding places in body
... the T-cells strongly enough to prompt the cell to express latent virus but not to trigger other cellular fun... needed to over-stimulate T-cells to force them to express latent virus. This ran the risk of harming the patient by impairing the entire immune system. In ...Empowerment in cyberspace - Electronic discussion helps cancer patients cope
... mailing list is a unique room where the women can express their frustration or joy, or simply ask questions. This means a lot to them, and it is a kind of therapy. When you tell your story on the mailing list you become visible. Illness and suffering not only isolates, but makes you passive and unable to ...The European Cancer Patient Coalition - challenges for the future
...ncrease of consumerism, and the growing freedom to express dissatisfaction with health services, this has helped fuel the patient advocacy movement," said Ms Redmond. "The European Patient Coalition hopes to increase cancer patients' influence over European health policymaking relating to cancer prevention, ...Fibroblasts hold clues to fat, scars and inflammation
...form specialized duties. In fact, fibroblasts that express Thy-1, a protein involved in growth function, can become myofibroblasts. In contrast, cells with no Thy-1 have the potential to become lipofibroblasts. Next, Phipps says, the group will more closely study the pathways for this cell transformation. Th...Disrupting two cell mechanisms in combination can suppress aggressive breast cancer in mice
...ed. For this study, transgenic mice were used that express the HER2/neu activated oncogene, a mouse model of ...o create more sophisticated mouse models that over express the oncogenes found in 25 to 30 per cent of human breast cancer, these models are much more reliable...