Zengen's new study reviews novel approach to control inflammation using melanocortin receptors
...t pleural mesothelioma," showed that activation of express melanocortin 1 receptor (MC1R) by selective peptides or peptidomimetics might provide a novel strategy to reduce mesothelioma cell proliferation by taking advantage of an endogenous inhibitory circuit based on alpha-Melanocyte-Stimulating Hormone (a-...New breast pap smear detects early cellular changes; May prevent onset of breast cancer
...ages are transmitted to CBP and p300 CBP and p300 express their own proteins that enable the cell to better utilize vitamin A for its tumor-suppressing activities. Seewaldt likens the process to a relay race. If one first runner doesn't connect with the next runner, the entire loop is broken. "We've always ...Problems controlling anger lead to weight gain for teens
...knowledge their feelings of anger, but are able to express those feelings appropriately. These children tend to have normal weights. "It is not just 'anger in' or 'anger out,'" Mueller said. "We're suggesting that it is important to look at the emotional health of kids. It's beyond just diet and exercise....New eggs continue to develop in adult mice
...wild-type mice into adult female mice developed to express a particular type of protein, called green fluorescent protein (GFP), in all cells throughout their bodies. When later examined microscopically, the transplanted ovarian tissue contained wild-type follicles housing GFP-positive oocytes, indicative o...Should nurses conduct breast cancer follow-up visits?
...en felt there was no opportunity to ask questions, express emotional concerns or talk about their social situation. "Other research has found that 70 to 80 per cent of recurrences have been detected by the patients themselves and this casts doubt on the effectiveness of follow-up visits with oncologists and ...Prototype system developed by Wright State computer engineer allows blind to 'see'
...that will enable the visually impaired to visually express their artistic talent beyond the usual levels. "The Tyflos camera captures images from the surroundings, and the portable computer reconstructs the 3D space for motion detection, body tracing, face recognition and moving objects," explained Bourba...Mild noise damage can be detected by cells in the inner ear
...ells were extremely sensitive to ATP, and may well express an as yet unknown novel receptor for ATP. Rather than trying to study this subtle process in live animals, the work was done using tissue preparations, but published experiments from another ear research group have shown that the levels of ATP inside...Advances in prevention and treatment research hold promise for 'pipeline'
...lock the growth of breast tumors that functionally express progesterone receptors," said Jens Hoffman, MS, Ph.D., the studies lead investigator. Hoffmann and his colleagues from the Schering AG Corporate Research Business Area Oncology tested the new progesterone receptor antagonist in tumor cell models and ...Single cocaine exposure boosts both drug craving and avoidance
...conditioning," in which the animals are allowed to express either an attraction or aversion to two differently colored and textured chambers where they have received one of two drugs or a placebo. Before the rats were introduced to the training environments, they were injected with a dose of cocaine. They we...Sedative may offer new direction in colon cancer treatment
... that had been injected with colon cancer known to express the GABA receptor, and found that four out of 10 mice treated with Nembutal developed primary tumors, compared to eight of 10 mice that did not receive the drug. And the cancer spread to the liver in only 20 percent of Nembutal treated mice, compared......ngiogenesis, in human pancreatic cells that do not express an enzyme called COX-2. ...genesis and tumor growth in pancreatic tumors that express COX-2. "Basically, for the first time, we have shown that a selective COX-2 ...UCLA research explores biology of fear
...latest in a series of studies of how mice acquire, express and extinguish conditioned fear, the UCLA team finds yohimbine helps mice learn to overcome the fear faster by enhancing the effects of the natural release of adrenaline. Adrenaline prompts physiological changes such as increased heart and metabolism...Researchers testing compounds that may stop replication of T-cell leukemia virus
... Despite what can be tedious work, the researchers express excitement about their studies."It's the unknown," Dennison said. "There's no rule book that comes with what to expect here. We don't know much about this particular enzyme, so everything we find out is building our knowledge base toward understandin...When 'switched on' muscle stem cells morph to resemble nerve cells
...tted to become muscle, were genetically altered to express the new gas pedal gene attached to a molecular switch. To his delight, the experiment worked. When REST-VP16 was turned on in myoblasts, it was enough to block the cells' entry into the muscle differentiation pathway and caused them to show neuronal...Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
...monal therapy," says Tannir. "Prostate cancer does express EGF receptors in late stages and androgen independent cancers have high expression." Tannir, as well as other M. D. Anderson researchers working with Iressa, say that while the drug has potential that has not yet been discovered, it probably ...Survey of adults reveals life-long consequences of ADHD
... without ADHD. Adults with ADHD are less likely to express a positive self-image. Only 40 percent of the adults with ADHD "strongly agree" that they have a bright outlook on their future, versus 67 percent of the adults surveyed without ADHD. Additionally, only half (50 percent) of the adults with ADHD sur...Disruption of a gene may prevent type 1 diabetes, UVa researchers find
...nctional Stat-4 protein," Yang said, "IL-12 cannot express its biological function in many types of immune cells. LSF mainly inhibits Stat-4 protein function, leading to suppression of IL-12 biological action in cells. This is one mechanism explaining why LSF has prevented diabetes in our previous studies." ...'Good guy' blood cells are now suspects in heart disease, diabetes
...n platelet samples, they discovered that platelets express PPARg, a transcription factor that was believed to be expressed only by cells with a nucleus. Activation of the PPARg protein by certain anti-diabetic drugs blunts the ability of platelets to release pro-inflammatory mediators and to form clots. Stud......for identification only and does not constitute an express or implied endorsement or recommendation by the institutions or their agents....