Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer
...to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogenesis, the formation of new blood vessels to the tumor. "This trial represents another step in a series of recent important advances in treatment for patients with advanced lung c...Finances, not having a dentist are primary barriers to seniors receiving needed dental care
...r periodontal disease, which we now know is a risk factor for heart disease, and for cancerous lesions." Of the 208 seniors who did report barriers to receiving dental care, 191 named finances; 92 named not having a dentist; 52 named transportation and the weather, and 34 named anxiety/depression. Zitt...Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
...as CD8+ T cells insensitive to transforming growth factor beta (TGF-beta), a powerful, naturally occurring substance in the body that enables cancer cells to evade surveillance by the body's immune system. The immunosuppressive effect of TGF-beta in cancer progression is well established. After inserting a...Gene for age-related macular degeneration discovered by Yale researchers
... that the gene for a substance known as complement factor H (CFH) on chromosome 1 is associated with AMD. "This is the first study to identify a common variant of the specific gene being associated with AMD," said Hoh. "Caucasian AMD patients are at least four times more likely to have one particular alte...New guideline tackles leading cause of mother and child death
...for both mother and child. The most important risk factor for developing pre-eclampsia is a previous history, show researchers at the John Radcliffe Hospital in Oxford. Diabetes and a high body mass index almost quadruple the risk, while mother's age and raised blood pressure are also significant. Many feta...Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
...lioblastoma which not only serves as a prognositic factor for survival, but also as a predictor for response to chemotherapy. This observation paves the way for using the unique tumor genetic signature as a guide for individualizing therapy and optimizing outcome."...Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
...2 group. About the Technology VEGF-2 is a growth factor that is believed to promote the development of supplemental collateral blood vessels, a process known as therapeutic angiogenesis. In the Phase IIb trial (GENASIS) for severe angina, VEGF- 2 is delivered to the ischemic heart muscle in the form of "...Blood pressure treatment could cut risk of strokes and heart attacks
...re sufferers. Blood pressure is the commonest risk factor contributing to the global burden of disease, and with a projected 1.5 billion sufferers of hypertension by 2020 it is vital that we develop more effective treatments." The complete results of the ASCOT trial will be made available when all data up t...Emory Study finds HIV is not an independent risk factor for severe heart disease
...iac catheterization, it was not a significant risk factor for severe CAD. "This suggests that factors other than HIV play a significant role in the development of severe CAD in patients who are HIV positive. Lifestyle and traditional cardiac risk factors (hypertension, hyperlipidemia, tobacco, etc.) appear...Cigarette smoke worsens respiratory infections in infants
...mental to the child's health." Age is another risk factor for serious RSV infection. The younger the child, the more serious the infection tended to be. Castro blames that increase in risk on lung and airway development. The tiny windpipes of small children can become clogged with mucous and other secretion...Even mild depression increases long-term mortality in heart failure
... shown that depression appears to be the main risk factor for these patients. In the Nov. 30 issue of the journal Circulation, Jiang found that while anxiety and depression are highly correlated in heart failure patients, depression alone predicts a significantly worse progrnosis after one year. Jiang is cu...Gender gap for lung cancer rates narrowing
...ide from the stage of disease, being a man was the factor that most negatively impacted survival among patients. "Lung cancer is the leading cause of cancer-related mortality for women in the United States," said Paul A. Kvale, MD, FCCP, President of the American College of Chest Physicians. "Although it ...Tobacco industry pays scientists to challenge secondhand smoke's link to infant death risk
...be recognized as an established, controllable risk factor for SIDS, like prone sleep positioning," they conclude. "Clinicians and public health officials should intensify their efforts to promote reducing infant exposure to secondhand smoke as an effective strategy for reducing SIDS." The documents show tha...Proteins found in urine of pregnant women could help diagnose preeclampsia
... proteins studied were vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their soluble VEGF receptor (sFlt1). The ratio of sFlt1 and PlGF had a high sensitivity ...A shallow hip socket predicts osteoarthritis of the hip
...sed at a mild degree, as a strong independent risk factor for OA of the hip, even in an elderly population. Led by Dr. M Reijman and supported by the Dutch Arthritis Association, the research team drew its subjects from The Rotterdam Study, a comprehensive investigation of the incidence of, ...The impact of cruciate ligament rupture on osteoarthritis of the knee
...ure as a widely under-recognized and under-treated factor in knee OA. The study focused on 360 patients with advanced, painful knee OA, recruited through the cooperation of Boston University Medical Center and the Boston Veterans Affairs Healthcare System. Just over 66 percent were male, and th...Inflammation elevates risk of cardiac death in rheumatoid arthritis patients
...e. "We believe that inflammation is a strong risk factor for cardiovascular disease among rheumatoid arthri...oid arthritis disease severity, such as rheumatoid factor positivity, ESR, joint swelling, radiographic changes, rheumatoid arthritis nodules, rheumatoid arth...New substance that improves the photodetection of bladder cancer gains market approval
...al urologist or surgeon is a considerable variable factor in successful detection. The recurrence rate under this treatment is quite high, and is thought to be due in part to superficial lesions or small tumors that are overlooked during the initial screening and diagnosis. The use of hexaminolevulinate (HA...Other highlights in the March 2 JNCI
...er risk. However, breast density was a strong risk factor for breast cancer even after taking into account reproductive and hormonal risk factors. The authors conclude that a component of breast density that is independent of estrogen-mediated effects may contribute to breast cancer risk. Contact: Eve Harri......s in the day-to-day lives of youth, which may be a factor in promoting positive outcomes, according to the r...provide a high level of monitoring -- an important factor in preventing substance abuse -- when they have only periodic contact with teens. Mentors may also i...