UCSF researchers discover new piece of puzzle in cancer development
...er, engage in a molecular dialogue withsurrounding fibroblasts that is critical to their development into full-fl...en the fibroblasts, so-called carcinoma-associated fibroblasts (CAFs) --which look the same as normal fibroblasts, but are not -- were grown next to"initiated" hum......rmation of new blood capillaries and the growth of fibroblasts that replace the connective tissue ofthe deeper layer of the skin and produce the collagen fibers that give strength to the repair. Inaddition honey stimulates the growth of epithelial cells that form the new skin cover over a healedwound. Honey th...Scleroderma research receives a boost from multiple NIH grants
...immune system is thought to stimulate cells called fibroblasts to produce excess collagen. Currently, there is no treatment that controls or stops the underlying problem: the overproduction of collagen. Little is known about the cellular changes that cause the skin and organs to harden, and the disease...JCI table of contents, November 4, 2002
...onic fibrosis and are thought to derive from local fibroblasts inresponse to TGF-beta signaling. Screening for ge... 1349-1358) that forced P311 expressiontransformed fibroblasts into myofibroblasts in vitro, and that itsexpression in vivo during human wound healing is consisten...Fibroblasts hold clues to fat, scars and inflammation
Scientists used to think that fibroblasts the cells that form basic tissue structures were...cal Center scientists have discovered that certain fibroblasts have highly specialized duties and play a major role in how scars form, fat accumulates, and harmful...Bone marrow stem cells build new circulation to lungs
...AH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls. Right ventricular systolic blood pressure (the pressure when the heart contracts) was measured 21 days later. The systolic pressure of the untreated, normal rats was 26......ne cardiac transplant model. The authors show that fibroblasts expressing allogeneic MHC class I molecules as well as a Notch ligand from the Delta-like family may be used to repress the recipient anti-alloantigen response and prolong graft survival following transplantation. Furthermore, the authors determine t...Bone marrowderived stem cells active in pulmonary fibrosis
...in the lung do not. Most of the collagen-producing fibroblasts observed in the lungs of these mice fluoresced green, indicating that they were of bone marrow origin. In an accompanying commentary Sarah Dunsmore and Steven Shapiro from Harvard Medical School discuss this new concept in pulmonary fibrosis. They st...Penn study shows how next-generation diabetic drugs could work more selectively
...ors. In addition to its beneficial role, TZDs turn fibroblasts into fat cells by enlisting more coactivators than normal, thus leading to weight gain. The goal is to design a SPPARM that will reduce interaction with corepressors, but increase interaction with coactivators, to separate anti-diabetic effects and w...