JCI table of contents, November 4, 2002
...ells. They participate in wound healing andchronic fibrosis and are thought to derive from local fibroblasts inresponse to TGF-beta signaling. Screening for genes that were upregulatedduring smooth muscle myogenesis, Lucia Schuger and colleagues identifiedp311, encoding a protein without functional domains su...Bacterial protein kills tumors
...icularly susceptible, such as patients with cystic fibrosis or severe burns. The bacterium protects itself from destruction by killing macrophages, the immune system's first line of attack against a foreign body. In the UIC study, specially-bred immunodeficient mice implanted with human melanoma were treated ...New avenue of HIV damage found
...mph tissues," said Schacker. Second, the amount of fibrosis and scar tissue in the T cell zone was significantly related to the size of the CD4 population in that space (i.e. the more scar tissue, the fewer cells) and the recovery of the CD4 population with therapy. The researchers suggest the process of dest...Cipro, related antibiotics over-prescribed, fueling microbe resistance
...ic fibrosis. Lung infections in people with cystic fibrosis traditionally have been treatable with fluoroquinolones. Cipro and related drugs are the only antibiotics patients can take orally to combat Pseudomonas aeurginosa, the most common bacterium associated with cystic fibrosis, Guglielmo said. Pills off...Antibiotic could offer promise for treatment of cystic fibrosis
...cin could offer some benefit to people with cystic fibrosis if they do not respond to conventional treatment, ...study in this week's issue of The Lancet. Cystic fibrosis is a severe genetic disorder-the most commonly recessively inherited disorder in white populations. ...Viagra for alleviation of pulmonary hypertension?
...al condition causing respiratory impairment. Lung fibrosis (scarring of the lungs due to inflammation of the alveoli) can be complicated by pulmonary hypertension. Hossein Ardeschir Ghofrani and colleagues from University Hospital, Giessen, Germany, did a preliminary randomised controlled trial to compare th...Drug developed at Duke appears effective in treating respiratory failure in newborns
...ronic obstructive pulmonary disease (COPD), cystic fibrosis and sickle cell disease. The researchers tested ENO on seven Duke newborns with persistent pulmonary hypertension, or high blood pressure within the lungs. In this potentially life-threatening disorder, blood vessels within the lungs constrict, sever...U-M artificial lung showing promise, as need grows
...ve chronic respiratory diseases, such as pulmonary fibrosis and emphysema, for which the only effective treatment is lung transplant. But the shortage of donated lungs means that patients sick enough for a transplant wait an average of two years for an organ, and 80 percent die before receiving one. Currently...Blocking adhesion protein may reduce lung damage from radiation
...diation pneumonitis (lung inflammation), pulmonary fibrosis (the accumulation of collagen, or scar tissue, in ...kocytes contribute to inflammation, which leads to fibrosis and decreased lung performance. However, it remains unclear whether blocking ICAM-1 expression can a...Blocking gene may reduce lung scarring caused by radiation therapy
...itial inflammation was the cause of the subsequent fibrosis and whether preventing the inflammation would in t...echanisms involved in the development of pulmonary fibrosis in these patients....Statement from Spondylitis Association of America
... it more prevalent than multiple sclerosis, cystic fibrosis and Lou Gehrigs disease combined. Unfortunately, many people with spondylitis go undiagnosed for years, and end up suffering long-term spinal damage. In severe cases, untreated spondylitis can lead to fusion of the spine and/or a significantly stoop...Obese lung-transplant recipients at higher risk of death
..., emphysema, chronic bronchitis, asthma and cystic fibrosis are waiting for lung transplants, according to the United Network for Organ Sharing. In 2000, less than 1,000 received transplants because of the scarcity of donated organs. In the UF study, researchers followed through the fall of 2000 the progress ...American Thoracic Society Journal news tips for April (first issue)
...hat cannot be seen through a bronchoscope. Cystic fibrosis (CF) is an inheritedmetabolic disease whose chief symptom is the production of sticky mucus that clogs the respiratory and gastrointestinal tracts. The aim of the study was to understand the effect of lower airway infection on clinical parameters, p...Mayo Clinic researchers identify gene for inherited kidney and liver disease in young children
...ment of multiple fluid-filled cysts in the kidney, fibrosis in the liver and often poor lung development and neonatal death. "Identifying the causative gene is a major step forward, as the progression of the disease can now be studied. It improves the prospects for gene-based diagnostics," says Peter C. Harr...Chronically ill kids put up defenses to hide depression
...er, 121 children who had juvenile diabetes, cystic fibrosis or rheumatoid disease for more than a month, and 368 healthy children. These results leave the unanswered question as to whether defensiveness is an adaptation that helps or hinders children. By seemingly blocking out depression and anxiety symptoms,...Dead sea environment helps sufferers of heart conditions, cystic fibrosis
... the environment also can provide relief to cystic fibrosis patients. Prof. Edward Abinader of the Faculty of ...e improving the efficiency of breathing for cystic fibrosis patients. This made them more able to exercise and enjoy daily life," Dr. Berkovits says. "The ext...Researchers gain insights on pulmonary fibrosis
...e that, like most diseases, the cause of pulmonary fibrosis will likely be a complex interplay between suscept...f Human Genetics in Vienna, Austria. Pulmonary fibrosis occurs when the thin layer of tissue around the lung's alveoli -- the tiny air sacs where gases are ...... fatty liver disease (NAFLD) can progress to liver fibrosis and eventually to cirrhosis. In Europe and Asia, estimates of the prevalence of the disease range from 14 to 21 percent, but no estimates exist for the United States. Using data from 13,500 adults who participated in the Third National Health and Nu......cations used to treat ailments ranging from cystic fibrosis to cancer. Krauland began making the particles last summer. First, he formed nascent aerosol particles by emulsifying DNA-containing solutions into polymer-containing solutions to produce tiny droplets. Using freeze-drying equipment, he next removed ......ng the discovery of the gene that codes for cystic fibrosis and the refinement of the electrocardiogram as a clinical tool for diagnosing heart disease. Markel is a recipient of a Robert Wood Johnson Foundation Physician Faculty Scholars Award, the James Shannon Director's Award of the National Institutes ...