Study Injects New Interest In How Vaccines Work
...re proteins made by the immune system to fight off foreign substances. Antigens -- the proteins or molecules that stimulate the immune system to create antibodies -- are condensed and collected on the surface of aluminum hydroxide particles. Since 1934, aluminum hydroxide has been used as an adjuvant to boos...New Approach To Multidrug Resistance
...-- such as hormone fluctuations or anincursion of foreign chemicals. Because the gene for P-glycoprotein isinducible, activated by cues from its environment, investigators were interestedin how it would be affected by cancer chemotherapy drugs. They focusedinitially on one group of drugs called DNA cross-l...Common Drug-Capsule Coating Not As Inert As Previously Thought
...insand other biological materials from sticking to foreign or man-made materials. Recent work at the University of Illinois, however, has revealed that thispolymer is not as inert as researchers thought. Chemical engineering professor Deborah Leckband and graduate studentShailesh Sheth used a surface-force ...Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
..., cyclosporin A andFK506, prevent the rejection of foreign organs or bone marrow by disrupting thesignaling pathway that activates T cells. But both drugs can cause kidney andnervous system damage, making them unsuitable for wider clinical application.The newly identified peptide prevents a single, specific ...Chemical Society's Highest Award Goes To Ronald Breslow
...This is true largely because cancer comes not from foreign cells, "butfrom normal ones that are misbehaving. They've lost their balance, and we try torestore it." Two such chemotherapy agents are promising so far in animal trials withthe National Cancer Institute. Every kind of tissue needs t...New Study Designed To Improve Outcomes In Women With Metastatic Breast Cancer
...The vaccinelets the body recognize cancer cells as foreign and to mount an immune responseagainst them. Accordingly, use of the vaccine after a transplant - when thevolume of residual tumor cells is relatively low - may be the ideal situation. However, an inevitable period of severe suppression in t...Unsticking The "Glue" In Blood Cells Could Save Lives
...'s defensemechanisms don'trecognize that something foreign has invaded the bloodstream. As a result, thecancer cells arefree to move anywhere, stick someplace and form another colony." This life-threatening process is called cancer metastasis. The Hopkinsresearcher wants toblock metastasis so that a sur......to lead a reasonablyhealthy life." In most foreign countries, treating very premature infants is lessaggressive than in the United States, she said. By David Williamson Note: Doron, a mother who works parttime, can be reached at (919) 966-3476 (w)or 682-837...Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy
...a key part of the immune system's defenses against foreign invaders, to enterthe microcapsule. The microcapsules wrap each islet in a semipermeable mesh. "IgG has a molecular weight of about 150,000, and insulin's is about6,000," Grinstaff said. "That's a very big difference. So the idea is that webu...Safe Water, Medicines, Insecticides Greatest Needs After Mitch
...ries most affected by HurricaneMitch to coordinate foreign health assistance. This coordination effort isnecessary, according to Dr. Prado, to ensure that external aid meets the realneeds of the countries. PAHO, which is also the regional office for the Americasof the World Health Organization, issued an em...Duke Physicians: Clinicians Have Ethical Obligation To Consider Alternative Medicine
.... Alternative therapies aren't necessarily foreign to clinicians adheringto the conventional practice of medicine. Adjustments to diet andrecommendations of exercise to reduce stress can be seen as alternatives tomedicine, but are accepted parts of patient treatment by both conventional andalternativ...Antabuse May Inhibit Fatal Reaction To Anesthetic
...ess by which our bodies transform andeliminate the foreign compounds. Halothane is transformed in the liver into amolecule that binds to liver proteins. In most people, this process has nosignificance, but in some people these liver proteins stimulate the formation ofantibodies that seriously damage the live...Maternal Tissue Typing Could Improve Selection Of Kidney Transplant Donors
... "Finding ways to induce immune tolerance to foreign tissue is the ‘Holy Grail’ of transplantation researchers," notes Steve Rose, Ph.D., chief of NIAID’s genetics and transplantation branch. "This study could provide important new insights into mechanisms of immu...New approach supercharges immunotherapy
...own as CD3, a cell-surface molecule thatrecognizes foreign tissue. Nearly ten years ago, however, Chicago researchers Craig Thompson and JeffreyBluestone and others discovered that the immune system often requires twoparallel lines of communication -- through both CD3 and a second receptor, knownas CD28 -- b...USC Researcher Lights Up The Immune System To Help Heart Transplant Recipients
...ay an important role in mounting a defense against foreign molecules. For each patient, Barr and his colleagues then treated these T-cells, which specifically recognize and attack the donated organ. The T-cell attack is what causes rejection. These T-cells were then inactivated by adding a drug,......smswhich teachimmune cells to recognize and attack foreign bodies." In people with autoimmune disorders, the immune system attacks its owntissues andorgans and must be re-taught to differentiate between the body's own cells andforeign attackers. "This therapy is analogous to rebooting a computer--you wi...MIT Microchip Releases Chemicals On Demand
...f themicrochips (Santini, Cima, and Langer), and a foreign patent covering allaspects of the microchip technology (Santini, Cima, Langer and Göpferich). With a prototype chip in hand, what's next? "We want to do the engineering to make this into a real application," Professor Cima said. "Also, we want t...Vaccine Against Melanoma Proves Successful For Patients With Disease Spread To Two Lymph Node Areas
...hemically modifies them. The modified cells appear foreign enough to the body'simmune system for it to react against them. In the June 1997 issue of the Journal of Clinical Oncology, Dr. Berdreported the results of treatments on patients with melanoma spread to a singlelymph node site (stage III dise...Sex Can Boost The Immune System
...ell says. "Theimmune system would respond to these foreign antigens by producing and releasingmore IgA." This could give them better protection against colds and flu.Why there was no IgA rise in the most sexually active group is less clear. "Myfeeling is that the people in the very-frequent-sex group may be ...Baby Talk: Parents Do Make A Difference, By Promoting Childhood Chatter, From Birth To Age 3
...get piping Mozart to your unborn fetus or flashing foreign words at yournewborn: "All you need to do," Hirsh-Pasek says, "is to talk and listen. Yourbaby wants to communicate with you. And, when toddlers are immersed in language,they use their language earlier and more efficiently." Over the years, some expe...