Teasing out the early steps of neurodegeneration
...w the accumulation of ataxin-1 affected the normal function of the cell1s nucleus. And, we wanted to understan...he and her colleagues would like to understand the function of PCCMT , the first gene to be downregulated, since it might be a key to later malfunctions in the...Bristol-Meyers Squibb submits NDA for new formulation of once daily videx(R)(didanosine)
...h as pancreatitis, peripheral neuropathy and liver function abnormalities. The most frequent side effects observed in adults taking the recommended dose of VIDEX in combination studies (AI454-148 and START 2) include diarrhea (69%, 45%), nausea (24%, 53%), neuropathy (22%, 21%), headache (20%, 46%), rash (11%...Missouri scientist takes 'rocky' road to NASA
...nd people still retain some sight. But they cannot function normally with that limited sight," he said. "In many cases, our system lets them lead a somewhat normal life." Eyeglasses cannot intensify the brightness of what a person can see, only the clarity. The new system "cures" both. A blind person wears a...AIDS researchers get $10 million to continue studies
...ed to the understanding of how HIV destroys immune function and how the immune system can be restored The institute, in its announcement, said the focus of future research will be antiretroviral treatment strategies, developing new ways to prevent or treat opportunistic infections and focusing on the growing...How psychology helps improve medical decision making
...sition for decision making increases linearly as a function of expertise. Research into decision-making strate...ne problems. The development of this strategy is a function of sophisticated knowledge structures and is implicitly acquired during training. Physicians use hyp...More research needed to gauge estrogen's effects on Alzheimer's disease, Yale scientists say
...proving or stabilizing the deterioration of mental function associated with Alzheimer's disease. After one year, study results showed no improvement in mood, memory, attention, language and motor skills. The study was conducted over a longer period and enrolled more women than past studies. Using a methodo......cally benign and compatible with silicon. It could function as another station in the line in the creation of a basically silicon micromachine, but with a diamond layer for additional strength and durability. It could one day be used as a complete replacement for polysilicon." Silicon MEMs (MicroElectroMecha......g the potential of IL-4 inhibition to improve lung function and control the symptoms of people with asthma. Interleukin-4 (IL-4) is a naturally occurring cytokine, or immune system protein, that has been commonly associated with the development of asthma and allergies. It binds to specific IL-4 receptors (IL...Scientists: herb known as comfrey can ruin liver, other herbs appear helpful
...t tended to have either a slower decline in mental function or small improvements. "However, the role that this specialized extract of Ginko biloba can play as an alternative or an adjunct agent for the treatment of dementia needs to be delineated by control studies clarifying the dose-response relationship ...MCG researchers find clues in process that enables working memory
...') that appears to regulate how dopamine receptors function in the cerebral cortex and other areas of the brain as well. "This protein may help us understand how dopamine modulates working memory," Dr. Bergson said. They have found that calcyon directly interacts with dopamine D1 receptors and, in the presen......ournal, Science . Known as "working" memory, this function is critical because it allows individualsto briefly hold information in mind during thinking and comprehension tasks.Working memory can become disturbed in people with many conditions, includingschizophrenia. New research may ultimately suggest impro...Health risks from impaired drug metabolism
...morphism in the same region of the chromosome. The function of the new variation hasn't been studied yet, but Schwarz reports that it is more common among African Americans than CYP2C9*3 and is likely to affect drug metabolism. Schwarz's research has important implications for the administration of drugs th...Artificial liver moves toward commercialization
...provides temporary support of a person's liver function can serve as a bridge to transplant or as a short-...totype devices still under development. To make it function longer than other models, researchers are using freshly isolated pig liver cells -- believed to ...Study shows women more likely to have severe arthritis, less likely to undergo surgery
...wn to significantly reduce pain, increase physical function and therefore improve quality of life," says the study's lead author, Dr. Gillian Hawker, director of the clinical epidemiology program in the University of Toronto's Faculty of Medicine and a rheumatologist at Sunnybrook and Women's College Health S...Protease inhibitor could help prevent alzheimer's
...e sequence database. They eventually connected its function to Alzheimer's, though they originally were looking at a protease found in human immunodeficiency virus (the virus that leads to AIDS). Their research experience with similar compounds and the HIV inhibitor contributed to the design of memapsin 2, Ta...Researchers identify pathway that may slow the progression of Lou Gehrig's disease
...fmk or placebo continuously for 56 days. The motor function of the mice was measured by timing how long they were able to stay on a rotating treadmill-like device called a Rotarod at a certain speed. The mice who received the highest doses of zVAD-fmk survived for an average of 153 days, as compared with 126 ...Smoking in later life linked to impaired intellect
... After adjusting for factors known to affect brain function in older people -- depression, general health, alcohol use, and educational levels -- the researchers found that smokers were up to four times more likely to have evidence of significant intellectual decline than either non-smokers or former smokers....New evidence suggests reconsidering causes and treatments for schizophrenia
...vidence that there is an alteration of cholinergic function in patients with schizophrenia," says Rajiv Tandon.... Finally, it shows that modulation of cholinergic function in schizophrenic patients has significant impact on both positive and negative symptoms." In the ...OHSU researchers discover new synapses in brain
...synapses may provide a key for understanding brain function in health and disease. These results appear in the May 11 edition of the journal Nature. Oligodendrocytes produce myelin, a sheath that surrounds and insulates nerve fibers. This insulation allows nerve fibers to transmit signals at high speed, l...Drug-psychotherapy combo found highly effective in depression study
... years that they could sustain pleasure and function fully at work and with families and friends." The study is the largest ever undertaken of medication alone, psychotherapy alone and an aggregate of the two, to treat chronic forms of major depression. The psychotherapy was de...