Tag: "gene" at medical news
Newly discovered virus linked to childhood lung disorders and Kawasaki disease
... Yale University used molecular probes targeting a gene
that is common in human and animal coronaviruses t...ch the sequence of chemical building blocks of the gene
differed from that of known human coronaviruses. The Yale investigators, terming the novel virus ind...
Future of clinical medicine research is at risk, warns professor
...port of the latter, he will discuss the current UK gene
therapy programme for cystic fibrosis. He says: "...or critical methods for determining the success of gene
therapy in this disease has driven our group to use state of the art basic research techniques, appl...
New network of gastrointestinal immune cells discovered
...ally altered mice in which one or both copies of a gene
required for cell migration and dendrite formation was replaced with a gene
that produces a fluorescent protein. Examination of the animals' tissues revealed populations of de...
Exposed: Tobacco industrys' efforts to cast doubt
...ing tobacco smoke to cancer-causing mutations in a gene
called p53 are detailed in a study published onlin...January 14, 2005) in THE LANCET. Damage to the p53 gene
leads to uncontrolled cell division. Mutations in this gene
are found in over 50% of all human tumou...
New insight into link between homocysteine and stroke
...sociation between stroke and common variation in a gene
called MTHFR, which is known to influence homocyst...comments: "Because of the random allocation of the gene
variant in advance of disease development this concordance of risk estimates implies that the relati...
USC/Norris oncologists test new front-line therapy for pancreatic cancer
...upt cell signaling in what scientists call the Ras gene
pathway. The Ras oncogene drives cell division and...ncers' development; moreover, mutations in the Ras gene
occur in 90 percent of pancreatic cancers. By throwing a roadblock in the Ras signaling pathway, BAY...
Leading researchers in allergic disease to gather for 2005 AAAAI Annual Meeting
...aturday, March 19. With his development of the DNA gene
sequencer and other automated biotechnical instrumentation, Dr. Hood has played a crucial role in contributing to the successful mapping of the human genome during the 1990s, a process originally predicted to require up to 100 years to complete. Mor...
Entrepreneurism Center at UC San Diego funds commercialization of lung, shock, other devices
...steps: determining the functional variants in each gene
locus that is linked to the disease and the effect of functional variants on the regulation and gene
products of the gene; and understanding how these intermediate phenotypes affect disease outcomes. U...
Gene vaccine protects mice against development of Her2/neu breast cancer
...tein. For this study, the researchers inserted the gene
for the HER2/neu protein in place of the deleted viral genes and then packaged the virus vector into virus-like replicon particles, referred to as "VRP-neu." When these non-propagating particles are injected into an animal, the vector directs the ani...
Jefferson scientists find zinc may help prevent esophageal, oral cancers
... She and her co-workers compared COX-2 protein and gene
expression in esophageal and tongue tissue in normal rats, zinc-deficient rats and in zinc-deficient rats that had received zinc. They found COX-2 expression was increased 10-to-15-fold in zinc-deficient rats. Cellular proliferation was similarly inc...
Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
...g normal cells. This project exploits unique viral gene
therapy developed in Mayo's Molecular Medicine program. Mayo research teams will conduct a clinical trial testing the effectiveness of this treatment on adult gliomas. Project 3 will study a protein that brain cancers use to invade surrounding tissu...
Antibiotics protect nerves in mice by turning on genes
...chers discovered that the antibiotics activate the gene
encoding glutamate's main transporter in brain cells. Rats and mice that received daily ceftriaxone for up to a week had triple the usual amount of the transporter, known as GLT1, in their brain cells, an effect that lasted for up to three months aft...
USC researchers find evidence that progesterone signaling influences ovarian cancer risk
...her of two previously unexamined variations in the gene
that codes for the progesterone receptor, accordin...lar version-or allele-of the progesterone receptor gene
(PGR). The PROGINS allele, says Celeste Leigh Pearce, a preventive medicine researcher from the USC/...
Study of hypoxia and new gene reveals early-stage action of p53 tumor suppressor gene
...e known for a decade that the p53 tumor suppressor gene
is important for killing cells as they proliferate...er of the University of Pennsylvania, discovered a gene
related to p53 called Bnip3L that can also cause cell death. The gene
is turned on by p53 and a seco...
Residual tumor cells are a barrier to targeted cancer therapeutics
...ity of Pennsylvania report that after blocking the gene
c-MYC, which is commonly overexpressed in human br...MYC. Additionally, by sequentially turning the MYC gene
on and off in these tumors in order to simulate the treatment of patients with multiple rounds of a ...
Very shy children may process some facial expressions differently
...icular forms of the serotonin transporter promoter gene
predicted smaller responses to overtly hostile and neutral facial expressions in certain regions of the brain. The researchers suggest that their findings indicate diminished brain involvement and partially impaired reading in response to some facial...
Blood protein predicts risk of heart attack
...y from person to person. Several mutations in the gene
that codes for MBL result in lower than average concentrations of circulating MBL. The authors suggest that MBL may protect against heart attack by binding to and helping clear the oxidized forms of cholesterol that build up in arteries. This type o...
Animal studies show stem cells might make biological pacemaker
...toral fellow at the School of Medicine, inserted a gene
(for green fluorescence protein) so that the human...ns scientists reported that inserting a particular gene
into existing heart muscle cells in a guinea pig allowed the cells to create a pacemaking signal. If...
Scientists identify protein critical to melanoma growth
... a chemical that quashed the activity of CDK2, the gene
that manufactures CDK2 protein, dramatically slowe...-Farber/Children's Hospital Cancer Care. The CDK2 gene
and its protein (an enzyme) are one of several regulators of the cell cycle: That is, they help dete...
Blocking molecules protects health of implants
... blocked by means of a protein decoy via localized gene
delivery. "What we found is that in the absence of CCL2 these large cells do not form at the site of the implant, therefore protecting the implant from damage," Kyriakides said. He said the significance of the finding is discovering a new and more co...
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