Discovery Hints At Multitude Of New Targets For Drugs
...ptors reside deep in the cell'snucleus, activating genes that produce cellular responses. When a hormoneor drug plugs into a receptor, that action changes the shape, or conformation,of the receptor. Previously, most scientists believed that this conformationalchange could only produce an on-off response....New Approach To Multidrug Resistance
...ively low doses of these DNA-damaging drugs affect genes selectively. Genesactive in day-to-day housekeeping -- for example, those involved in cellstructure or basic food metabolism -- are less vulnerable to damage than genesinduced in response to external signals -- such as hormone fluctuations or anincu...Chemist Turns To Self-Assembly To Create New Drugs
...e used to create drugs to inactivate ras andher-2, genes that play roles in some forms of cancer. Finding new drugs is a numbers game, and the odds shoot updramatically when chemists can peruse thousands or even millionsof candidates. Currently technicians and customized robots searchfor potent new dr...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...focuses on defining the function of certainmutated genes which are known to cause cancer, and on developing innovativetherapies to reverse the effects of the mutation or to kill thecancer cell. Onyx pursues a strategy of establishing corporate partnershipsthat provide complementary skills in chemistry, dr...Polish Dumpling-Like Particle Has Potential In Drug Delivery
...ators hope someday will be the carrier of drugs or genes for biomedical applications and therapies. Karen Wooley, Ph.D., assistant professor of chemistry at Washington University, recently announced a new breakthrough in the particle that K. Bruce Thurmond, II, a graduate student in Wooley's group, first...Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
...ria, parasites,viruses and cancer; and location of genes that contribute to the development ofdiseases like breast, lung and prostate cancer. Wistar is a National CancerInstitute Cancer Center....Lupus Foundation Of America Awards Summer Internship To Student Working At Wistar Institute
...ia, parasites, viruses and cancer; and location of genes that contributeto the development of diseases like breast, lung and prostate cancer. Wistar isa National Cancer Institute Cancer Center....University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence
... a virus as a transfer agent, will introduce human genes into thecell. The genes are selected for their ability to generate an immune responsetoward cancer cells. The cultured cells......ocombinatorial chemistry exploits the discovery of genes and theirproteins, which serve as molecular targets for drugs because they controlbiological processes that often lead to disease. "With this approach, we start with a chemical compound called a platformthat locks onto a specific molecular t...Scientists Discover How Aspirin Reduces Inflammation
...ction ofspecific genes, which in turn act on other genes causing a cascade of eventsleading to inflammation...way. Since NF-kB is a critical inducer of cellular genes involved in theinflammatory process, aspirin inhibition of this kinase prevents NF-kBactivation and ......bacco plants so far grown only in greenhouses. The genes inserted into the tobacco DNA orders the production of human enzymes, which can be extracted, purified and used to develop pharmaceuticals. The gene that produces the protein cannot be "turned on" until scientists give it a specific signal or induc...WFU And IntraVec To Develop Innovative Cancer And HIV Treatments
... the cell. But some people withcertain "defective" genes do not produce the chemokine that permits "docking...y plans to develop a "gene screen" used toidentify genes coding for proteins that elicit an immune response. The companywill license the screen to pharmaceut...Substance Discovered That Induces Hair Follicle Formation In The Mature Skin Cells Of Mice
...ctor that binds to the cells DNA and activates the genes that instruct the cell to become a hair follicle. Uri Gat, a postdoctoral fellow in Fuchss lab, created mice that constantly produced a stabilized form of beta-catenin in their skin. (Normally any excess beta-catenin that is not needed for cell-cel......eyond identifying and elucidating the functions of genes to designing novelclasses of disease-modifying drugs that selectively regulate the activation ofdisease-causing genes. The Company conducts its target and drug discoveryprograms both independently and with its five collaborative partners:Ares-Serono...Discovery May Boost Effectiveness Of Chemotherapy
...edresistant and non-resistant cancer cells to find genes that were different amongthe two groups. They used molecular biology techniques to isolate the uniqueBCRP gene from drug-resistant cancer cells. Then, they tested their theory bychanging non-resistant cells into resistant ones by inserting the BCRP g...Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
...e structural studies clarify how estrogens turn on genes and show precisely how tamoxifen blocks this process," said first-author Andrew Shiau, agraduate student in biochemistry & biophysics at UC San Francisco. "Thissets the stage for intentional design of drugs with precise and selectiveaction." Estr...UF Researchers Cite Possible Link Between Autism, Schizophrenia And Diet
...With autism in particular, there are three or four genes that havesparked interest," he added. "The assumpt...means notonly does one have to figure out what the genes are but also what they doand their relative contribution to the symptoms of the disorder. This isnot...... the last few years, we have been able to identify genes that result in manyof these disorders, said Dr. Rimoin. "Through genetic testing, family members ofindividuals with skeletal dysplasia can determine whether they carry the gene,which allows couples to make informed decisions when planning a pregnancy......vement. To date, five spinocerebellar ataxia (SCA) genes have been identified: SCA 1, 2,3, 6, and 7. The ch...thinSCA2 cells that differ from those in the other genes associated withneurodegenerative diseases. Before the discovery of SCA2 and the other altered genes,......mune system with a DNA vaccine, which consisted of genes takenfrom a SHIV. The genes express specific SHIV proteins that help the bodyproduce an initial immune response. This was follow...