Tag: "genetically" at medical news
Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...y which leptin signals the body to burn fat. Using genetically
obese micethat lacked the leptin protein, research...d a saline placebo to the other group. Because the genetically
obese miceproduced no natural leptin, it was easier to track the effects of the artificialleptin. R...
Duke Obtains FDA Designation For Pompe Disease Therapy
...sease is fatal. The Duke clinicaltrial will test a genetically
engineered form of the enzyme, expressed ina cell line developed in the laboratory of Dr. Y.T. Chen, chief of the Divisionof Medical Genetics in the department of pediatrics. Initially, the drug will be tested in a small number of Pompe diseaseinfan...
Researchers Finding May Boost Effectiveness Of Anti-HIV Drugs
...njected protease inhibitors into mice thathad been genetically
engineered not to express Pgp, brain levels of the drugsclimbed to seven-to-40 times higher than in mice that normally express PGP. The researchers also found that brain levels of the protease inhibitorsin normal mice were about one-tenth the...
Area of Research Outlined For Promising New Cancer Drugs
... Research, and the Walther Cancer Center willstudy genetically
manipulated mice with deletions of angiostatin's parentprotein, plasminogen. Results from this in vivo research are expected to yieldgreater understanding of the angiostatin-plasminogen relationship in cancer,Castellino says. For more inform...
ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...er patients, the company cautioned. ONYX-015 is a genetically
engineered adenovirus that, in prior preclinical andclinical studies, has been shown to replicate in and kill tumor cells deficientin p53 tumor suppressor gene activity. Mutations in p53 are the most common typeof genetic abnormality in cancer, occur...
Advisory: Nasal Spray Influenza Vaccine
...y the summer of 1999. The vaccinehas proven to be genetically
stable and acceptable because it's administeredthrough a natural root via nasal passages. Maassab said that the vaccine isalso adaptable to other influenza viruses. "We have the methodology to constantly update the vaccine whenever new outbreakshave...
Dying To Quit: Why We Smoke And How We Stop
...ight gain of 20 or 30 pounds after quitting may be genetically
driven and that the small weight gain most quitters experience merely brings their weight up to what is considered normal. In assessing why so many of us continue to smoke, Brigham explores the behavioral economics of tobacco use. For many smokers, ...
More Bad News For Fast Food Fans
...holesterol. The researchers studied two groups of genetically
similar rabbits. Both groups were fed a low cholesterol diet but one group had a small amount ofoxidized cholesterol added. After only 12 weeks, the rabbits on the oxidizedcholesterol diet developed a 100 percent increase in fat deposits in theirao...
University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence
..." Jordan said. "We'veinvented a new technology to genetically
change the tumor cell." The researchers plan to ex... be reinfused into theirbody. Researchers hope the genetically
engineered cells will rev up the patient'simmune system to seek and destroy any remaining cancer cel...
Cyclosporin Appears Effective In Treating Heart Disease
...cineurin inhibitor, cyclosporin, to mice that were genetically
predisposed todevelop HCM and to rats in which HCM was induced. This prevented thedevelopment of HCM. "These results suggest that calcineurin inhibitors merit further study aspotential treatments for certain forms of human heart disease," says Dr.Mo...
UNC Researchers Find Drug-Resistant HIV In Semen
...as treatment went on. Andeight of 10 whose HIV was genetically
analyzed as the study continued showed"new resistance mutations" in their blood or semen or both. "We need to emphasize not only for personal health, but for publichealth, that the goal of treatment should be to get the virus to immeasurable...
Ovarian Hormone Could Play Key Role In Easier, Safer Childbirth
...ics Corp. of Palo Alto,Calif., have indicated that genetically
engineeredhuman relaxin softens affected skin in people suffering from scleroderma, adisease characterized by an increase incollagen fibers in the skin....
Commercial Scale Cultivation Of Pharmaceutical-Producing Tobacco Possible, Virginia Tech Scientists Find
...rmaceuticals on a commercial scale. CropTech has genetically
engineered tobacco plants so far grown only in gre... she said. It is also one of the easiest plants to genetically
modify. As a very prolific seed producer, it will allow production to be scaled up very rapidly. T...
WFU And IntraVec To Develop Innovative Cancer And HIV Treatments
...c cell" technology in which Chen andhis colleagues genetically
modified normal cells to produce and secrete a tox...s will be based on Chen's discovery of a methodfor genetically
altering white blood cells (lymphocytes) to make them imperviousto entry by the HIV virus. During in...
Substance Discovered That Induces Hair Follicle Formation In The Mature Skin Cells Of Mice
...be formed in places where it has been lost. The genetically
engineered mice were exceptionally hairy. In some... follicles. Unlike in embryogenesis, however, the genetically
engineered skin of the transgenic mice made an endless supply of beta-catenin and benign follicle tu...
Maternal Tissue Typing Could Improve Selection Of Kidney Transplant Donors
...ction, surgeons try to find donors who are genetically
similar to the recipient. The best outcomes are achieved when the donor is the identical twin of the individual who needs a transplant. In the absence of an identical twin, other siblings, such as those who share identical HLA genes, ...
Clinical Trial Demonstrates Experimental Growth Factor Increases Eligibility For Autologous Stem Cell Transplantation
...y. The trial demonstrated that the recombinant, or genetically
engineered, drug,called platelet growth factor thrombopoetin, is effective in stimulating stemcells --the body's primitive bone marrow cells and the ultimate source of allblood cells-- to migrate out of the bone marrow and into the bloodstream. Ther...
New Theory May Explain Ritalin Action In Hyperactivity
DURHAM, N.C. -- A study using genetically
engineered mice suggests adifferent mechanism of a... Caron and Gainetdinov made their discovery by genetically
creating"knockout" mice lacking a protein called a dopamine transporter that scavengesthe dopamine r...
Insulin Resistance And Obesity Avoided In Genetically Modified Mice, As Reported In Science
...abetes and obesity. Inthe scientists' experiments, genetically
engineered mice lacking a specificenzyme were able to resist weight gain and to avoid the decreased sensitivity toinsulin that characterizes type II diabetes, even when fed an extremely highcalorie, high fat diet. The results are reported in the 5 Ma...
UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
...nown.The researchers conducted their study in mice genetically
engineered to expressa cancer gene, or oncogene, in every insulin-producing islet cell of thepancreas. The result is that they develop a cancer known as islet carcinoma. The model was created in such a way that new, spontaneous pancreatic tumorscont...
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