Researchers complete sequence and gene map of human major histocompatibility complex
...sue of the journal Nature. The paper describes the genomic sequence of the major histocompatibility complex (MHC), a region on chromosome 6 essential to the immune system. The MHC controls many activities of the immune cells, including the transplantation rejection process and the killing of virus-infected ...Genetic test for melanoma developed at UCSF
... of cancerous ones. In a test called comparative genomic hybridization, they labeled DNA from normal and cancerous cells with different fluorescent dyes, then used these to identify the changes in the cancer cell's chromosomes. These experiments were conducted by Boris Bastian, MD, an assistant profe...... areas of drug development expected to emerge from genomic research over the next five years, including key therapy classes, technological advances and new delivery systems. When Consumers Rule: Defined-Contribution Benefits And The Internet In Healthcare, J. Philip Lathrop, MBA, National Advisor On Managed ...Jefferson scientists hope to perfect gene therapy without viruses
...ot a higher organism, though this was with a human genomic sequence." The Jefferson team was awarded a patent for the technique and a new grant for more than $660,000 from the National Institutes of Health to continue to develop their method of gene transfer in yeast and mice. Dr. Wickstrom notes that gene t...Researchers find better way to predict childhood brain tumor outcomes
..."The new work is an exciting example of how useful genomic studies can be to classify different tumor types, ...archers from several research centers applying new genomic tools to cancer. It turns out that simultaneous measurement of thousands of genes expressed in a tum...Duke researchers identify age at onset genes for Alzheimer's and Parkinson's disease
...line, Inc. The Duke research team conducted a genomic screen -- the first ever designed to study age at ...prehensive response to the broad challenges of the genomic revolution. The other four research centers include: the Center for Genome Technology, the Center fo...Applied Biosystems introduces next generation production level DNA analysis systems
... DNA analyzer for the industrial-scale analysis of genomic information. The 16-capillary ABI PRISM 3100 Genet...p new therapeutics. Celera intends to leverage its genomic and proteomic technology platforms to identify drug targets and diagnostic marker candidates, and to...Mayo Clinic researchers find useful test for identifying patients
... sometimes left with few explanations of why. Now, genomic medicine has helped Mayo Clinic researchers find a renewed use for a test once deemed ineffective in detecting a cardiac condition sometimes cited as the cause of previously unexplained sudden deaths. "This is a test we use to determine if patients a...Other highlights in the June 5 issue of JNCI
...east cancer cells. These genetic changes result in genomic instability. David M. Euhus, M.D., and colleagues from the University of Texas Southwestern Medical Center at Dallas, investigated whether LOHthe deletion of chromosomal material during DNA replication or repairwas associated with abnormal cytology i...Beijing conference to address lung cancer crisis in China
...y to clinical application. Its scientists focus on genomic analysis of lung cancer and mesothelioma and application of gene therapy and oncolytic viral gene therapy for these malignancies. UCSF is one of 30 centers in a National Cancer Institute (NCI) study launched last month to determine if screening peopl...New approach for studying traumatic injury
...mpile an extensive database including demographic, genomic and physiologic information about patients with traumatic injuries. In the process, they plan to develop standard operating procedures for burn and trauma patients and to develop clinically relevant animal models. Washington University and Stanford U...In 15 seconds, new test will ID presence of 25 most common mutations of cystic fibrosis
...utation(s). The bead-array test requires only that genomic DNA be taken from the patient, usually through a blood draw. Following the blood draw, the genomic DNA is isolated and single-tube PCR amplification of the genomic DNA is performed against the 31 dif...UCSF-led team discovers possible cancer 'susceptibility' gene
...e growth control of the cell. While the impact of genomic instability on cancer development remains hotly debated, Balmain and many others believe that it incites a spiraling chain reaction of unregulated behavior that can lead to the accumulation of mutations in key regulatory genes. When enough mutations ...HHS announces new regional centers for biodefense research
...nts of bioterrorism Developing computational and genomic approaches to combating disease agents Creating new immunization strategies and delivery systems In addition to the eight RCEs, NIAID is funding two Planning Grants for Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases ...UCSD-TCAG collaboration to focus on transformation of genome-based knowledge into health benefits
...s (TCAG) today announced a formal collaboration in genomic medicine that combines large-scale human genome an... collaboration, the two organizations will conduct genomic studies aimed at elucidating the links between multi-gene associations and the prediction and outcom...NIAID reports 'tremendous progress' in biodefense research
...eated new biodefense resources, taken advantage of genomic research advances, and furthered understanding of how microbes cause disease and how the immune system responds to infection. Highlights from the NIAID biodefense progress report include the following: Partnerships in Product Development--In addition...NIH funds two UCSD scientists to venture deep into human genome
...nderful foundation, but obviously having the human genomic sequence is not enough. We must keep on exploring this newfound wealth of knowledge if we are to realize the full potential of genome research to improve human health." Ren explained that his research will test the efficiency of a genome-wide loca...Young breast cancer patients who chose lumpectomies need indefinite follow-up
...e should also be aware that recent developments in genomic techniques could in the future allow the risk of local recurrence among these younger women to be defined more accurately."...Mayo Clinic researchers discover genetic syndrome linked to inherited birth disorder
...ghout the genome, and their role in giving rise to genomic rearrangements is under intense investigation in research laboratories throughout the world. Knowing that chromosome 22 was vulnerable to rearrangement, Dr. Jalal theorized that rearrangement would lead to deletion as often as it did duplication. "Su...