Alcohol researchers confirm molecular culprit of alcohol-induced liver damage
...F-alpha receptors provides a direct way to testthe hypothesis that this cytokine is important in the initiation and progressionof alcohol-induced liver injury," said senior study author Ronald Thurman,Ph.D., professor of pharmacology and nutrition at the UNC-CH School of Medicine. According to Dr. Thurman, phag...Use it or lose it applies to nervous system, scientists find
...rry in andout of synapses strengthens the synaptic hypothesis of learning. "It comes as asurprise that the stable, stupid neuromuscular junction of mammals, where no onewould consider that learning is taking place, has a very similar mechanism tothe one that is thought to alter the strength of synapses in the b...Pathway may provide target for treating chronic pain
...lutamate receptor interacting protein (GRIP). "One hypothesis is that GRIP binds to the cell at an AMPA receptor site insideof the cell," Zhuo said. "Then, under certain conditions, the receptor movesitself to the synaptic part of the neuron. That movement activates the formerlysilent synapse." Receptors at syn......re responsible for the rebound in plasmaviremia, a hypothesis that will be illuminated by further studies." Co-authors of Drs. Chun and Fauci include Richard T. Davey, M.D., DelphineEngel, and H. Clifford Lane, M.D. NIAID is a component of the National Institutes of Health (NIH). NIAID conductsand supports res...Study finds marijuana ingredient promotes tumor growth, impairs anti-tumor defenses
...h was assessed three times each week. To test the hypothesis that THC impairs tumor-specific immune system response, a group of mice with compromised immune systems was also studied. The researchers found that in the mice with normal immune systems there was significant enhancement of tumor growth, but THC ...Drug therapy significantly extends lifespan of worms
...he aging process, this work supports his long-held hypothesis that oxygen radicals generated in the mitochondria during metabolism are a major cause of degenerative diseases and aging. As byproducts of energy generation, says Dr. Wallace, oxygen radicals generated inside the mitochondria inhibit mitochondri...NIH funds unique diabetes program that combines research with technology development
...vorably upon proposals unless there's a very clear hypothesis and there's a very discreet biological problem that you are seeking to solve with methods that are approved by the community at large," said Newgard. "So we really did feel like it was a gamble to go and say, 'We're going to do two biology projects, ...AstraZeneca reaffirms belief in CHARM study
...rther stated: "With regard to testing the 'add-on' hypothesis for the use of AT1-receptor blockers in heart fail...ore the need for the independent validation of the hypothesis that the CHARM study programme will provide." Confidence that the CHARM study programme will prov...Insulin precursor linked with increased stroke risk; may represent new risk factor
...t of first stroke are unclear, Lindahl notes. One hypothesis is that high proinsulin levels act as a marker for an underlying metabolic disturbance. It has already been shown, in both diabetics and nondiabetics, that proinsulin has a stronger association than insulin to several cardiovascular risk factors, ...Getting older and feeling weaker?
...veloped a proposal for NIOSH funding. "Our central hypothesis is that older, more experienced workers would have greater endurance on the job if we could learn how tasks can be adjusted to their work capacity," Nussbaum says. To test this hypothesis, Nussbaum will recruit groups of young workers 18 to 24 y...Georgetown researchers to present evidence of biological cause of dyslexia
...g to be able to see such clear confirmation of our hypothesis in the fMRI scans," Eden said. "This is a great step towards better understanding the neural mechanisms involved in reading and learning." Zeffiro and Eden and their colleagues from the University of Pittsburgh, Wake Forest University School of Medic...UCSF researchers move in on role of brain's naturally occurring marijuana
...esses. While merely speculative at this point, the hypothesis is reasonable, says Wilson, as the cell receptor through which cannabinoid acts has been conserved through evolution, suggesting the cannabinoid molecule is beneficial to many species. "It seems to me than anything expressed so heavily and conserv...Methadone may cause potentially fatal arrhythmia, Georgetown researchers find
...s have not yet been confirmed in humans, but their hypothesis about methadones role in causing arrhythmias came from anecdotal reports to an international registry that Woosley and his colleagues established to collect cases of cardiac arrhythmias following administration of specific medication(s). The registr...Training for doctors improves screening for risk-taking in teens
...improves risk-screening practices," Ozer said. The hypothesis of the larger ongoing study, titled "Implementing Adolescent Preventive Guidelines," is that not only screening but brief counseling for risky behaviors can be significantly increased. In addition to training, the ongoing study offers formal methods ......ults were quite a surprise," said Dr. Bender. "Our hypothesis was that the group receiving diphenhydramine would score significantly lower. We thought the kids reactions to the medications would be similar to those of adults." Dr. Bender cautions that this one study does not settle the question about diphenhydr...Methadone promotes HIV infection in cell culture
...y to an active state. "These results support our hypothesis that, like other opiate drugs, methadone may raise the risk of HIV infection," said Dr. Ho. "Further investigations should be done to study whether our laboratory results accurately reflect how HIV infection progresses in patients receiving methadone......ars. This landmark trial was designed to test the hypothesis that increasing the removal of certain toxins could reduce patient mortality, the primary endpoint of the study. Patients were randomized to two study groups: the active control group was prescribed a standard 2L exchange four times a day, which is...Four researchers awarded Dutch Nobel Prize
...wer than theory would suggest. Professor Oerlemans hypothesis is that this is a delayed effect of the last ice age. The further measurements which he plans will help discover more about the present state of the icecap, which is an essential component of climate modelling....Heavier white female workers earn less
...lace discrimination," Cawley points out. "Another hypothesis also consistent with these findings is that heavier workers are less productive at work. It has repeatedly been found, for example, that obese workers are more likely to miss work due to illness. However, this explanation is complicated by the fact...UNC to share in $34 million study of what happens to cancer patients
..." how peoples literacy affects their health. "Our hypothesis is that people who cant read and cant understand written information given to them by physicians or hospitals might not be able to negotiate the medical system and not do as well," Sandler said. UNC investigators also will collect blood samples and t...