Other highlights in the August 20 issue of JNCI
...on the risk. "The findings are compatible with the hypothesis that lifetime risk of testicular cancer is determined early in life, possible before birth," the authors conclude. Study Reevaluates Role of Carcinogen-Activating Enzyme Previous studies in cell cultures suggested that the enzyme CYP12A activate...Nanomedicine: Grounds for optimism and a call for papers
...ion of research articles, reviews, viewpoints, and hypothesis papers in the field of nanomedicine, as defined by NIH. The closing date for submissions is Dec 31, 2003. A theme issue of the journal is being planned for the spring of 2004.'...Finding the link between fat and high blood pressure
...oposal wrote. "The goal of this study is to test a hypothesis that links adolescent obesity to cardiovascular di...oached by the proposed studies. Whether or not the hypothesis turns out to be correct, important new data will result from the proposed study."...Brain transportation system defect linked to Huntington's by UCSD team
...ocking axonal traffic. "These findings support our hypothesis that blockage of neuronal transportation is related to several neurodegenerative diseases," said the study's senior author, Lawrence S.B. Goldstein, Ph.D., UCSD professor of cellular and molecular medicine and a Howard Hughes Medical Institute invest...Immune alarm system can both amplify and silence alerts, scientists find
...omputational model of the immune synapse theory, a hypothesis formulated eight years earlier by Shaw and two coauthors in Washington University's Department of Pathology and Immunology, Michael Dustin, Ph.D., and Paul Allen, Ph.D. The three had speculated that when T cells bump against another type of immune ...UCSF & SF Bay Area receive federal funds to expand breast cancer / environmental research
...s initially on two projects. Both are related to a hypothesis that changes in breast tissue during adolescence, potentially influenced by environmental factors, may create conditions in young women that put them at risk for breast cancer later in life. UCSF's Werb will lead the basic science research. Recogniz...Use of statins may prevent breast cancer, say University of Pittsburgh researchers
...s to prevent breast cancer with these agents." The hypothesis that reduction in total fat will result in a decreased risk of breast cancer is being tested in a separate study that is part of the Women's Health Initiative (WHI), an ongoing set of clinical trials involving 161,000 women, testing preventive measur...In lab studies, blocking expression of gene reduces invasion of deadly brain tumor cells
...ade neighboring tissue. The new study supports the hypothesis that laminin-8 is involved in the spread of these malignancies, and it reinforces the possibility that a therapy may be developed to arrest the tumors by targeting the gene. In the original study, published in Cancer Research, the scientists used "ge...Common drug, given promptly, reduces incidence of post-traumatic stress disorder, small study finds
...hours, days, or even a week or longer. The working hypothesis of the new model is that these are the people who are at greatest risk for developing post-traumatic stress disorder, in which a person experiences recurring emotional attacks, for months, years or decades following the inciting event. PTSD patients ...Stroke treatment may come from physiological determinations not time frame, says Pitt
...ntly used selection based on time," he said. "The hypothesis remains to be proven in prospective studies using imaging technologies that will allow accurate identification of core and penumbra in acute stroke patients," he added. Also participating in the study from the University of Pittsburgh were Howard Yon...Heart attacks rose at Brooklyn hospital after terrorist attack
...1, to 39.3 percent in the 60 days afterward. "Our hypothesis is that the rate of unstable angina was lower because more patients with unstable angina progressed to acute heart attacks and acute cardiac arrhythmias," Feng said. Researchers examined medical records for patients who received emergency cardiac ev...Hearing problems may be programmed at birth
...mes more often taking drugs. The thrifty phenotype hypothesis is applicable to hearing loss, say the authors. They suggest that a low level of growth hormone (IGF-1) before birth leads to a reduced number of cells at birth, which results in short stature and earlier onset of age related disorders....Glycerin may help skin disease, study finds
...kin cells mature properly. "This is a pretty novel hypothesis that is really quite in its infancy," Dr. Bollag says of the finding that glycerol works as a signal to help direct skin cells through their four normal stages of maturity. In the endless cycle of skin-cell production, the youngest cells move up from...Surgery without radiation inadequate for DCIS, study reveals
... 3, is the first prospective study to evaluate the hypothesis that DCIS (a common type of breast lesion that is ...The Dana-Farber research began in 1994 to test the hypothesis prospectively enrolling patients at the time of treatment for DCIS and monitoring them for recurren...Moderate alcohol consumption linked to brain shrinkage
...of Public Health. "Our findings do not support the hypothesis that low or moderate alcohol intake offers any protection against cerebral abnormalities or the risk of stroke in middle-aged adults." For the study, Dr. Ding and his colleagues used magnetic resonance imaging (MRI) to measure the brains of 1,909 men...Brain area identified that weighs rewards
... one side or the other of their visual field. "One hypothesis that this research raises is that what's happening in such cases is that there's no motivational significance or emotional significance to that part of the visual world. It has become meaningless to the patient, because the posterior cingulate cortex...Did Crohn's disease evolve with the advent of refrigerators?
Authors of a hypothesis article in this week's issue of THE LANCET propose...ris, France, and colleagues discuss the cold-chain hypothesis (the production and storage of food in low temperatures) as a potential major risk factor for Crohn'...When alcohol consumption evolves from a 'social lubricant' into a 'crutch'
...s, which should be the case if the self-medication hypothesis were completely correct." The self-medication hypothesis proposes that some people use alcohol or other drugs because they experience relief from existing ps...American Thoracic Society Journal news tips for January 2004 (first issue)
... said that their findings were consistent with the hypothesis that chronic cough is associated with abnormal release of inflammatory mediators within the airway. All of the subjects were non-smokers. The age of the controls was approximately 48 and that of the coughers averaged 53 to 55 years. Among the subj......rn of elevated levels was more random. The subway hypothesis was tested by sending a Columbia University student underground with two personal monitoring pumps and a particle counter for a total of eight hours. The airborne levels of Fe, Mn, and Cr in these two subway samples were more than two orders of magn...