Tag: "immunosuppressant" at medical news
New Test May Improve Treatment Of Kidney Disease
...ture plates andexposing them to common steroid and immunosuppressant
medications, scientistscan predict in somecases what medications might work best for each patient. If a patient's white blood cells are suppressed by the medications, it ishoped that the patientwill respond favorably to treatment. By contrast...
Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
...the April 24 Molecular Cell. The two main immunosuppressant
drugs used today, cyclosporin A andFK506, prevent the rejection of foreign organs or bone marrow by disrupting thesignaling pathway that activates T cells. But both drugs can cause kidney andnervous system damage, making them unsuitable for wider cli...
Double transplant frees patient from need for immunosuppressive drugs
...ceivedcyclosporine right after the transplant, the immunosuppressant
was tapered offand discontinued on the 73rd day after the procedures. Two post-transplantdonor-white-blood-cell infusions were also given in an attempt to suppress hermyeloma, which remains at a nearly undetectable level at this time. Thomas Spitz...
Aerosol form of cyclosporine hits key cellular target in lung transplant patients, researchers report at international meetin
... target an important biological process that other immunosuppressant
drugs, including oral cyclosporine, have not been ...closporine aerosol spray along with their standard immunosuppressant
therapy, which includes oral tacrolimus, plus steroids. The subjects in the P-gp study were drawn f...
Pitt's transplant team uses standard stem cell procedure in unique way for recipient of living donor kidney transplant
...rom living donors must take a life-long regimen of immunosuppressant
drugs to protect their organs from being rejected. Such drugs can cause serious complications, such as tumor growth, and make patients more susceptible to infections. Transplant tolerance, which refers to the state by which a patient's immune system ...
Hope for kidney transplant patients of improved graft survival
...riorating kidney function show that the use of the immunosuppressant
CellCept (mycophenolate mofetil, MMF) allows for t...ney failure and transplant loss. CellCept, a newer immunosuppressant
drug, is non-kidney toxic and the study set out to discover whether the use of CellCept could effect...
Pitt study: Chronic rejection rare for pediatric liver transplant patients on tacrolimus
...30 Pediatric liver transplant patients taking the immunosuppressant
tacrolimus do not appear to be at risk for developing chronic rejection, according to a long-term follow-up study of 166 children transplanted at the University of Pittsburgh between 1989 and 1992. The results of the study were presented today at the...
Data shows life of kidney transplant lengthened by CellCept
...ating kidney function switched to the low toxicity immunosuppressant
CellCept (mycophenolate mofetil, MMF), kidney deterioration reversed and significantly improved, thus halting the progression towards kidney loss, and improving patients outcomes. Kidneys are the most commonly transplanted organ with 30,000 transplan...
Studies offer new treatment option to prevent kidney rejection
... is studying the effectiveness of rapamycin, a new immunosuppressant
that controls the immune system differently than its more widely used counterpart and, according to Inman's preliminary findings from a study in rats, may do so without harming the kidney. "The kidneys treated with cyclosporine fared much worse that...
EliTE-Symphony study recruitment begins
...y, we have the opportunity to evaluate established immunosuppressant
treatment regimens that have never been compared before in such a way. We hope to show that CellCept® in combination with Zenapax® can allow for the safe reduction of combined therapies such as cyclosporine, tacrolimus or sirolimus to non-tox...
UF researchers report: Immunosuppressant drug prevents late rejection of transplanted kidneys
... with how long to use these new and more expensive immunosuppressant
medications like CellCept. The newer work demonstrating the importance of low-level but persistent risk for acute rejection and its inhibition by CellCept is additional evidence for the strong recommendation that this particular medication be continu...
Transplanted kidneys from living donors survive longer with Neoral compared with tacrolimus
... patients and remains the most commonly prescribed immunosuppressant
Immunosuppressant everolimus significantly reduces life-threatening heart transplant complications
...HIA, Pa. (August 28, 2003) Treatment with the new immunosuppressant
drug everolimus is significantly more effective in reducing the severity and incidence of serious complications in heart transplant patients than the current therapy, according to a study in the Aug. 28 The New England Journal of Medicine. The study ...
NIAMS researchers collaborate to produce targeted immunosuppressant drug
...ord University have collaborated in studying a new immunosuppressant
drug, CP-690,550, that may avoid some of the commo.... None of the treated animals showed signs of such immunosuppressant
side effects as increased cholesterol, blood sugar, blood pressure or increased white blood cell cou...
Radically new anti-rejection drug shown to offer safe control of immune system in Stanford study
...amage to the nervous system and kidneys. The ideal immunosuppressant
would block the actions of the immune cells that cause organ rejection without interfering with other cells. CP-690,550 appears to be on that track. "Theoretically, the molecule that we are targeting with the drug is present only on immune cells, not...
Drug prevents diabetes recurrence after islet cell transplantation
...mpounds in humans to limit the need for more toxic immunosuppressant
drugs in islet cell transplant patients." In the study, diabetic mice that can only mount an autoimmune attack were given islet transplants in the kidney and then daily injections of LSF for 3 weeks. A control group was treated with only saline...
Heart transplant survival: Results may be key to rejection prevention, detection, treatment
...tion and its effects early," said Dr. Mehra. "New immunosuppressant
drugs provide another vital management tool in preventing or treating transplant vessel damage. It's a promising time in transplant research." Review abstracts and a complete meeting schedule online at www.ishlt.org . Media invited Late-breaking ...
CellCept's cardioprotective profile reinforced
...benefits for heart transplant patients as the only immunosuppressant
that offers: superior survival benefits reduc...lCept CellCept is the cornerstone of low toxicity immunosuppressant
therapy. It has been available to patients for 10 years, initially through clinical trials and more ...
CellCept associated with reduced incidence of cancer, compared to AZA, following heart transplant
...ed that heart transplant patients treated with the immunosuppressant
CellCept (mycophenolate mofetil) in standard immun...g-term prognosis." About CellCept CellCept is an immunosuppressant
or anti-rejection drug used in combination with other immunosuppressive drugs (cyclosporine and cort...
Tacrolimus + mycophenolate mofetil & steroids: Safe, effective in preventing acute cardiac rejection
Initial findings of an immunosuppressant
combination study in de novo cardiac transplant recipients presented today at the 24th annual meeting of the International Society for Heart and Lung Transplantation show a regimen of tacrolimus (TAC) + mycophenolate mofetil (MMF) and steroids to be ...