Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
..."We want to establish the precise timing where the inactivation of peroxynitrite will have therapeutic benefit," he says. "In the spinal cord, we know many of the changes occur within 24 hours. It's certainly feasible to give someone uric acid immediately and raise levels in 50 minutes. Whether or not this should...News tips for Sunday, November 7, 2004
...duration of time between electrical activation and inactivation of the lower heart chambers. In this study, researchers performed an ECG on newborns between the 15th and 25th day of life at 16 centers. By April 2004, ECGs were obtained on 21,397 infants. Among those, 173 (0.8 percent) had Q-T interval greater th...The anti-arthritic effects of bee venom
...ved in immune reactions. Thus, Melittin's targeted inactivation of inflammation may hold the key to the anti-arthritic effects of bee venom. "The potency of melittin in the inhibition of the inflammatory response may be of great bene...Inactivation of Alzheimer's disease genes in mice causes dementia and brain degeneration
...rs identified the molecular pathways through which inactivation of these genes in mice produces abnormalities strikingly reminiscent of Alzheimer's disease. The study, reported online in Neuron, may provide a new way to look at the cause of Alzheimer's disease, as it shows that the protein products of these Alzhe...'Switched-off' genes put first chink in colon cell's anti-tumor armor
...ly and died. The research team also found that inactivation of SFRP genes occurs in the earliest form of lesion, called an atypical crypt foci (earlier than polyps or cancer). Approximately 5 percent of these lesions become colon cancers. "The colon cancer process may start by shutting off SFRP genes, which...Sandia-developed foam likely would stop SARS virus quickly, Sandia/Kansas State team shows
...s in the tests, she says. New protocols for viral inactivation A second significant outcome of the joint researc...le in the scientific literature regarding chemical inactivation of viruses, says team member Jill Bieker, a Sandia intern currently working on a PhD at K-State. The...UCSD researchers describe cell activity leading to disruption of neuron migration
... The study concluded that Cdk5 phosphorylation and inactivation of doublecortin takes place normally in the develo...orylation is critical for migration, and that both inactivation and reactivation are required for the normal functioning of the protein. Gleeson's laboratory is cu...Other highlights of the May 21 JNCI
...persons with Barrett's esophagus by preventing the inactivation of p53 or by preventing further neoplastic progres...ed longer than normal melanocytes, suggesting that inactivation of p16 resulted in the impairment of cell growth inhibitory mechanisms. The authors say that their f......s been developed, the underlying mechanisms of how inactivation of the BRCA1 gene leads to malignant cell growth i...nd colleagues examine the mechanisms that underlie inactivation of BRCA1 and assess how they affect the management of patients, in terms of both primary (eg. Prophy...Other highlights in the September 18 issue of JNCI
...ultiple genetic mechanisms are responsible for the inactivation of BRCA2 in these tumors and that a majority of the tumors with BRCA2 dysfunciton also had BRCA1 dysfunction. The authors conclude that "some degree of BRCA1 and/or BRCA2 dysfunction may be of nearly universal importance for the process of ovarian ca...Mice lacking fat-making enzyme are leaner, more sensitive to leptin and insulin
...lly obese mice characterized by leptin resistance, inactivation of DGAT1 significantly reduced their obesity and insulin resistance. Obesity is a huge public health problem, so people are looking for drugs to cure it, said Robert V. Farese, Jr., MD, senior author, Gladstone investigator, and UCSF professor of med...Study points to potential role for caffeine in reducing the risk of Parkinsons disease
...everal known A2A antagonists as well as by genetic inactivation of the A2A receptor. The mouse study adds to epidemiological data published last year that documented how much coffee people drank and compared it to whether they developed Parkinsons. According to Schwarzschild, the results indicate that caffeine ......port in the February issue of Nature Genetics that inactivation of just one copy of a gene called PTEN and both copies of a gene called p27 leads to prostate cancer in mice 100 percent of the time. Mutations in the PTEN gene are frequently found in human prostate cancer. And, for the first time, scientists now ha...Jefferson Scientists Show Tumor Characteristics May Help Explain Tumor Biology And Prognosis
...SI is valuable as a pretest for DNAmismatch repair inactivation and possibly hereditary colon cancer," explains Dr.Boman, who is also director of the Division of Medical Oncology and MedicalGenetics in the Department of Medicine at Jefferson Medical College. They alsofound "the status of microsatellite instabilit...Emerging Pathogens And Safety Of Fresh Produce Key Issues Facing Food IndustryAnd Scientists
...ase their survival in acidic foods, decrease their inactivation in thestomach, and increase their virulence. Strains often associated with foodborneoutbreaks, such as Escherichia coli O157:H7, are among the most acid-resistant. This resistance also enables pathogens to resist other stresses such as heat,radiatio......oNumerik has designed BNP7787 to enhance selective inactivation of toxicplatinum drug species and to produce a less toxic drug relative to otherprotecting agents. BioNumerik presented preclinical animal study data showing that BNP7787 cancompletely protect against cisplatin-induced renal, emesis and bone marrowt...