Indiana University researchers closer to helping hearing-impaired using stem cells
...ously shown that the marrow stromal cells could be induced to transform into neuronal cells, but it wasn't clear whether, or how, the cells could be further transformed into useful specialized neurons. In a two-step process, Dr. Hashino and her colleagues first cultivated mouse marrow stromal cells with chem...NIH state-of-the-science panel calls for 'demedicalization' of menopause
...er, many women, particularly those with surgically induced menopause, do experience significant symptoms that greatly diminish quality of life. For women whose menopausal symptoms are severe and persistent, the panel found nothing as effective as estrogen therapy for alleviating those symptoms. Low-dose estr...GlaxoSmithKline receives unanimous favorable recommendation by FDA Advisory Committee for Boostrix
... immunogenicity. In addition, the use of Boostrix induced anti-pertussis antibody levels, which were statistically higher than those observed in infants following primary immunization with a DTaP vaccine (Infanrix) [Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed] in whom efficacy ag...Binge drinking can impair both mood and cognitive performance
...uals are not seeking treatment or aware of alcohol induced changes in their psychological make up." Researchers recruited 100 (50 males, 50 females) young (between the ages of 18 and 30 years of age) and healthy moderate-to-heavy social drinkers to answer numerous questions about their alcohol and drug use, ...Common anesthetics appear safe for developing fetal brain
...rane, one of the three commonly used agents, which induced reductions in oxygen metabolism along with increases in cerebral blood flow. Isoflurane is known to produce these actions in the adult brain but it had not been appreciated that such effects could also occur in the fetal brain, he said. Besides the o...Medical technologies may hinder rather than help newborn survival
...e or more doses of this vaccine. The percentage of induced deliveries increased from 2.5% (147 of 5914) in 1982 to 43% (1026 of 2386) in 2004. Rates of caesarean section increased greatly from 28% (1632 of 5914) in 1982 to 43% (1039 of 2403) in 2004, reaching 82% (374 of 456) of all private deliveries in 20...Orthodontists must brace against back pain
...help of up to five assistants. The body stress was induced by long periods of sitting (about 70 per cent of their workday), with 90 per cent of the strain coming from the tasks of applying, removing or adjusting braces. The research also showed that males bore heavier loads than their female counterparts be...Adverse drug events in nursing homes are far more common than previously identified
...ing transfusion or hospitalization, and medication induced drowsiness. More severe events included delirium, falls resulting in fracture, bleeding requiring transfusion, hypoglycemia., and kidney problems. In 2000, Dr. Gurwitz's team published a similar study which identified adverse drug events in community...Young blood revives aging muscles, Stanford researchers find
...ed the two mice to share a blood supply. They then induced muscle damage only in the older mice. Bathed in the presence of younger blood, the old muscles healed normally. In contrast, when old mice were connected to other old mice they healed slowly. In similar work, the group examined the livers of older mi...New highly active agents against sandfly fever
...m of leishmaniosis (kala-azar, the visceral form), induced by Leishmania donovani and L. infantum , affects about 500 000 people per year and proves fatal if no treatment is given. Although drugs do exist for treating these diseases, they are not always effective, owing to the appearance of resistant para...Induction at 32 weeks possible action for expectant moms with premature membrane rupture
...rs and babies do just as well when the mothers are induced at 32 weeks rather than later at 34 to 36 weeks, t... of women with premature membrane rupture who were induced at 32 weeks. The experiences of these women were compared against women with early membrane rupture ...Pathogen-mimicking vaccine as strategy for cancer therapy
...) from a melanoma antigen known as Melan-A/MART-1, induced CD8+ T cells that specifically recognized cells displaying Melan-A/MART-1 on their surface. This T cell response occurred in all eight patients in the trial. Responses were one order of magnitude higher than those observed in eight patients who recei...Special imaging study shows failing hearts are 'energy starved'
... cardiac CK flux at rest and with pharmaceutically induced stress to determine whether increased energy demand during stress increases the rate of ATP synthesis through CK. Then, 17 patients with histories of heart failure were similarly tested to measure the CK flux. Results showed that CK flux in healthy...American Thoracic Society Journal news tips for February 2005 (first issue)
... elevated in the placebo subjects. Acute altitude induced hypoxemia leads to an adverse condition in which, at a minimum, overall well-being is compromised and patients suffer from a reduction in physical performance associated with acute mountain sickness. In addition, a patient's life can be threatened b...Animal study shows link between nicotine and atrial flutter
...-related. "We were surprised to find that nicotine induced a considerable increase in atrial interstitial fibrosis in the dogs with myocardial infarction but only a mild increase in the dogs with no MI," Karagueuzian said. "These differential effects on atrial fibrosis occurred despite the fact that nicotin...Other highlights in the January 19 JNCI
...d their proliferation, migration, and invasion and induced their differentiation into vascular-like structures. In addition, tumors formed by the CR-1-transfected breast cancer cells had a higher density of microvessels than tumors formed by cells without CR-1. The authors conclude that CR-1 appears to have ...Controversial drug shown to act on brain protein to cut alcohol use
...ng that Ibogaine reduced alcohol consumption. They induced the rats to consume alcohol in daily drinking sessions and then demonstrated that their drinking declined precipitously when they received Ibogaine. The drug was administered either by injection or directly into the same brain region where GDNF level...Future of clinical medicine research is at risk, warns professor
... to washings from the lung airways and latterly to induced sputum, highly specific proteins relating to the disease and the inflammation have been identified. The same techniques have shown similarly promising results in other lung diseases including asthma and chronic obstructive pulmonary disease." Profes...Simple sputum test for confirmation of childhood tuberculosis
...s according to a standard procedure. Samples from induced sputum and gastric lavage were positive in 87% and...dren, respectively. The yield from one sample from induced sputum was similar to that from three gastric lavages. In addition, almost half of all culture posit...New therapeutic vaccine for HIV/AIDS eliminates needles and excessive toxicity
... shows that antiviral activity of immune responses induced by DermaVir are significantly longer than that of existing antiviral drugs. It is suggested that DermaVir would only need to be re-administered periodically, about 8 times a year, rather than daily. Current antiretroviral therapies used to treat HIV...