NIH Honors Emory Researcher With Merit Award For Work On Renin-Angiotensin System
... the excretion ofpotassium. The retention of water induces an increase in plasma volume and thusan increase in blood pressure. To further elucidate the effects of angiotensin, Bernstein, using arodent model, isolated and cloned the gene encoding the receptor for angiotensinII (Nature 1991), which has...Transcranial Magnetic Stimulation Enhances Short-Term Brain Plasticity
...re coil held outside the head. The magnetic field induces an electrical current in nearby regions of the brain. While TMS is often used to diagnose brain abnormalities, this report shows that it also can influence brain plasticity, or reorganization. This plasticity is thought to be responsible for much o...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
...al change in membrane potential. This induces the opening of voltage-gated calcium channels. The resulting calcium influx triggers a second messenger cascade which together with additional presynaptic effectors causes the aggregation of gephyrin beneath the activated ...Maternal Tissue Typing Could Improve Selection Of Kidney Transplant Donors
...e that prenatal exposure to maternal HLA molecules induces a long-lasting form of immune tolerance. Thus, when the recipient encounters the same HLA molecules in adult life via a sibling-donated kidney, this state of induced immune tolerance prevents rejection of the mismatched kidney...Interleukin-2 Boosts Cancer Vaccine Effectiveness In Mice
...ic receptors we need to fight thetumor. Then IL-2 induces those T-cells to rapidly divide and proliferate." The fact that interleukin-2 works at low doses in combination with the U-Mcancer vaccine is important, Mulé added, because the toxic effects of high-doseIL-2 therapy have limited its effectiven...Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
...l form of cancer. The experimentalagent, CMA-676, induces remission in a significant proportion of patients withfew serious side effects. CMA-676 represents the first successful applicationof antibody-targeted chemotherapy. AML is an aggressive, life-threatening disease in which certain white bloodcells b...Coffee: a cause of neonatal seizures?
...herefore the combination of these two factors that induces fits. Schematically, the caffeine molecule binds to adenosine receptors, therebyblocking the action of adenosine, the endogenous neuromediator, which plays animportant role in handling stress. During stressful episodes such as oxygenstarvation, adeno...Oxygen reduces effects of retinal detachment
...etinal areas that were not previously detached and induces their detachmentor prevents photoreceptor recovery," said Lewis. The research described in the second paper shows that providing oxygenduring detachment reduced all aspects of this type of cell abnormality inducedby detachment. The tw...UI researchers find more natural method to possibly induce vascular growth
...auses the heart to stretch, which Tomanek believes induces theanimal to produce VEGF. VEGF then triggers endothelial cells, the building blocks of the blood vessels,to proliferate. "VEGF causes the endothelial cells to migrate, line up and actually form thevascular structures," Tomanek explained. Tomanek an...New 'real time' MRI stress test pictures heart in motion
...e speed at which it contracts and relaxes. It also induces cardiac ischemia, a reduction in the blood being supplied to theheart. With the high-speed imaging, the physician can evaluate the ability of the leftventricular wall to move during physical stress. The fast cine MRI uses thehighest speed available ...Results of NUVANCE phase I/II asthma trial presented
...o the lung tissue resulting in inflammation. IL-4 induces B cell proliferation and the production of antigen-specific IgE that is required to trigger allergic response. Antigen-specific IgE causes mast cells to release inflammatory "mediators," such as histamines and leukotrienes, and these create bronchoco......nc. (Nasdaq: CLPA), demonstrate that Aptosyn™ induces a clinically significant reduction in the formation of precancerous colon polyps in patients with FAP after as little as six months of therapy. Moreover, patients who have continued on Aptosyn™ for more than one year continue to show further impr...Hutchinson Center receives $1.2 million from National Science Foundation to study plant genetics
...volves exposing the plant seeds to a chemical that induces point mutations, or single-base changes, in the plant's DNA. Plants are then grown from these mutated seeds, and the DNA is isolated from each. The individual DNA samples are then pooled, just like ingredients for a recipe are combined in a mixing bo...Free radicals mediate arsenic's harmful effects
...nd renal abnormalities," says Dr. Hei. How arsenic induces human cancer has been somewhat of a mystery for two reasons. First, arsenic is an oddball among human carcinogens in that it has not been shown to cause cancer in laboratory animals. Second, laboratory research on the mutagenic effect of arsenic in m...Study offers hope for chocolate-loving reflux disease sufferers
...a novel treatment. "We demonstrated that chocolate induces GERD symptoms by compromising the ability of the lower esophageal sphincter to prevent the stomach acids from creeping back up the esophagus," says Chung Owyang, chief of the U-M Division of Gastroenterology and professor of internal medicine in the ...Stanford researchers warm to cooling heart attack patients
...is connected to a specially designed device, which induces mild cooling to 91.4 degrees F, more than 7 degrees cooler than normal body temperature. "Basically, we're stealing heat from the body and sending it to a machine," Lee said. Patients are cooled for three hours, given medication to prevent th...Outsmarting cancer - new results from novel enzyme inhibitors
...ome immortal. PS-341 is a proteasome inhibitor. It induces the cancer cell to commit suicide by interfering with the proteasome that is allowing the cancer cells to divide uncontrollably. PS-341 has already shown promise against haematological cancers and Dr Johnston is involved with the first trials in brea...Stress leaves blood vessels tightly wound
...vides the first evidence that sudden mental stress induces endothelial dysfunction. Endothelial dysfunction occurs when the blood vessels ability to dilate is impaired. This effect is augmented by a chemical called endothelin-A (ETa). As a result, the blood vessels are unable to respond properly to change...USC researchers suggest possible cause for kidney cancer
...lains that when rodents were given a chemical that induces the tiny tubes in the kidneys to die off and then causes renal cell carcinoma, researchers saw signs of increased lipid peroxidation. However, when rodents were given a similar chemical that causes the tiny tubes to die offbut results in no cancerres...Use of tampons and sexual activity protect women against endometriosis
...ne contractions that are part of the female orgasm induces more effective menstrual fluid clearance of the uterine cavity, which in turn may facilitate cervical outflow. Further, the use of tampons may be more efficient at the removal of menstrual fluid compared to the use of pads."...