Leading the way in novel anti-cancer research
... interfere with crucial steps in cell division and inhibit the proliferation of cancer cells ...Bayer and Onyx announce new data on dual mechanism of action of BAY 43-9006
...t is known to target both Raf kinase and VEGFR2 to inhibit two essential mechanisms involved in tumor growth....xhibits dual activity in important mechanisms that inhibit cancer progression. These findings suggest that BAY 43-9006 may have a potential role in the treatm...GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
... tyrosine-sulfated peptides and their potential to inhibit HIV entry into the human host cell. "The entry o...ity to replicate. "Pharmacological strategies to inhibit Vif is a logical and attractive approach in the search for novel anti-HIV therapies," said Michael H...Investigational drug brings new hope to kidney cancer patients
...atients die each year. BAY 43-9006, is believed to inhibit an enzyme, known as Raf kinase, which regulates tumor-cell proliferation and may also play a role in the growth of new blood vessels to feed the tumor....Experimental drugs show promise in halting brain tumors
... that four new and experimental drugs can strongly inhibit the growth of deadly brain tumors in animals, and they expect these promising results to hold true in humans, as well. In fact, one of the drugs -- ZD6474 -- significantly slowed the growth of three different types of brain tumors, a remarkable findi...Northwestern Memorial enrolling participants in two trials on new drug to fight deadly cancer
...late the immune system to attack myeloma cells and inhibit the growth of new blood vessels (angiogenesis) that feed the "liquid tumor." "Multiple myeloma is incurable, but patients can have prolonged disease control using sequential therapies as needed," says Dr. Singhal. "The challenge is that the disease...Hot flash drug may hinder effectiveness of tamoxifen
...shes. However, these drugs have also been shown to inhibit the enzyme that converts tamoxifen to its known most potent metabolite, 4-hydroxy-tamoxifen, and other active metabolites. The implication is that co-prescription of SSRIs with tamoxifen may reduce the effectiveness of tamoxifen. Vered Stearns, M.D....Novel gene therapy delivery uses stem cells that target, attack tumors
...ed whether MSC producing human interferon-beta can inhibit the growth of metastatic tumors in the lungs of mi... "These results suggest that gene-modified MSC can inhibit the growth of leukemias, metastatic tumors of the lungs, and ovarian and brain tumors," he says. "We...Online support for people with depression
... support services for stigmatizing conditions that inhibit more traditional modes of information seeking," write the authors....Northwestern receives $10 million for cancer prevention trials
...Substances likely to be studied include those that inhibit an enzyme called COX, believed to be involved in cancer formation and spread. Aspirin and some other over-the-counter painkillers block production of COX, and some have been shown to prevent certain cancers. Other drugs and substances to be studied i...National vaccine advisory committee issues recommendations to strengthen supply of routine vaccines
... information and confidentiality requirements that inhibit the recognition of evolving problems and development of effective responses. The Committee concludes that: "Disruptions to the supply of routinely administered vaccines are likely to continue to occur. Action to implement short- and long-term solut...Combination therapy significantly delays progression of benign prostatic hyperplasia
...gs finasteride and dutasteride. The class of drugs inhibit the 5-alpha reductase enzyme, significantly lowering the level of the primary male hormone in the prostate, dihydrotestosterone, without affecting the level of testosterone elsewhere in the body. "Dr. Wilson's discovery set in motion a whole new era ...Spreading cancer survives via signals from nearby blood vessels long before new vessels are grown
... to block these signals from being released and to inhibit new blood vessels from forming." Such a strategy is called anti-angiogenesis. The two-way dialogue begins when cancer cells secrete proteins -- such as vascular endothelial growth factor (VEGF) and angiopoietin 2 -- that alert blood vessels to their ...Preliminary report suggests combination therapy may help treat SARS
...rove outcome. A group of drugs called interferons inhibit viral infections by boosting the body's immune response. In laboratory experiments, interferons were effective in inhibiting a strain of a SARS-related virus. Mona R. Loutfy, M.D., M.P.H., of the North York General Hospital, Toronto, Ontario, and c...Anthrax toxin inhibitor identified
...MS) has identified a group of small molecules that inhibit a deadly toxin associated with inhalational anthrax. Described in the January 2004 issue of Nature Structural & Molecular Biology, these findings could eventually lead to the development of a protease inhibitor drug, which in combination with antibio...Aspirin use may be associated with increased risk of pancreatic cancer
...animals have suggested that aspirin and NSAIDs may inhibit the development of pancreatic cancer. However, few studies have examined the association between analgesic use and pancreatic cancer in humans, and results have been inconsistent. Eva S. Schernhammer, M.D., Dr.P.H., of the Brigham and Women's Hos...'Science' showcases research on forgetting
...o stop an arm motion midstream can be recruited to inhibit or stop an unwanted memory retrieval. Instead of inhibiting activity in brain regions having to do with physical action, however, these control processes reduce brain activation in the hippocampus, a structure known to be involved in conscious memori...Discovery changes ideas about damage from strokes
...mation, or swelling (drugs like Celebrex and Vioxx inhibit COX-2 and are widely prescribed for arthritis and other inflammatory conditions), but its activity leads to the production of a number of different molecules which could be more directly responsible for its effects. Andreasson and her colleagues are ...Herceptin gives disappointing results in lung cancer trial
...NTACT, TALENT AND TRIBUTE) in which the aim was to inhibit receptors of epidermal growth factors. It was also possible that blocking only one of the growth factors was ineffective in NSCLC while there were parallel signalling pathways allowing the cancer to progress....Carnegie Mellon uses AFM to discover effects of experimental drugs on Alzheimer's plaques
...ulness of molecules like antibodies to effectively inhibit protein aggregation associated with Alzheimer's Di...derable efforts on developing molecules that would inhibit A aggregation or perhaps even break up existing plaques. In this quest, they have recently turned th...