New anti-angiogenic proteins discovered
...ery of two human proteins, METH-1 and METH-2, that inhibit blood vessel formation More potent than endostat...s (NASDAQ: HGSI) discovered two humanproteins that inhibit the formation of new blood vessels and have potential fortreating cancer through suppression of tumo......ice. Specifically, theydiscovered that these drugs inhibit the activation of a master regulator of theinflamm...-gamma, a nuclear hormone receptor, TZDsultimately inhibit the action of NF-kappa B, a master regulatory molecule in theinflammatory response. PPAR-gamma is lo...Study suggests potential new approach to glaucoma therapy
...ies, Neufeld and Becker will test other drugs that inhibit production ofNOS-2. If their work progresses, human trials may follow. This research was supported by grants from the National Eye Institute and theGlaucoma Foundation....... from a bully's target. However,having friends did inhibit victimization. Those that were most aggressive alsoreceived the highest ratings from teachers on emotional intensity." Presentation: "Bullying and Victimization in Early Adolescence- Descriptionand Prevention," Anthony D. Pellegrini, Ph.D., Univer...LSU scientist says new drug will save brain cells attacked by neurological injury or disease
...fected. Bazan's discovery of a novel mechanism to inhibit the expression of pathologicalgenes led to the development, in collaboration with organic chemists, of a drugthat renders these genes inactive in animal models of neurodegenerative disease. His laboratory will now enter the pre-clinical phase of rese...UCSF to attack HIV at molecular level with new center and $7 million in state funds
...evel of the biological factors that facilitate and inhibit HIVtransmission, how to prevent HIV infection, and how to delay progression ofdisease once a person is infected. This is the first time UCSF has had a single center focusing on this key areaof research. "This crucial funding from the state will fill ...Moderate levels of worry can motivate women to get mammograms
... behavior,high levels of cancer worry may actually inhibit mammography use," saidDiefenbach. "Our results also suggest that educational programs that focus onlyon raising worry and fear to motivate the recipient may ultimately fail unlessthey also include an action plan that lays out how the desired health ...MGH researchers identify angiogenesis inhibitor in gallbladder cancer
...levels of five factors known toeither stimulate or inhibit angiogenesis. The only one showing a significantdifference among the groups was TGF-beta-1, which was three times higher in themice with tumors in their gallbladders than in the subcutaneous or controlgroups, suggesting that it was the factor suppres...UI findings indicate DNA methylation process may lead to oral cancer
...zymes can be targeted bydrugs that are designed to inhibit the active sites for those enzymes." The findings of Domann's research team appeared in a recent issue of thepeer-reviewed European Journal of Cancer, Oral Oncology. Funding from theNational Institutes of Health helped support this research. In addi......ntinfections. These deadly but chronic viruses may inhibit some step in theprocess that normally allows cells to recognize a viral invader by itsdouble-stranded RNA and, with the mediation of PKR, to program cell suicide inresponse. Lau said there are several potential practical applications of his team'sdis...Pathway may provide target for treating chronic pain
...nin on the outside of the cell orusing peptides to inhibit the interaction between GRIP and AMPA inside the cell.Another strategy could involve a substance called protein kinase C (PKC). Likeserotonin, large quantities of PKC can activate silent synapses. In theseexperiments, Zhuo and colleagues have shown t...Abstemious mice offer hint at molecular target for treating alcoholism
...arch Center at UCSF. "Pharmacological agents that inhibit PKCe might prove useful for treatingalcoholism and provide a non-sedating alternative for enhancing GABA-A receptorfunction in therapy of other disorders, such as anxiety and epilepsy," Messingsaid. On a more fundamental level, the UCSF finding offer...Soy substances slow prostate cancer growth in animals
... isolate and soy phytochemical concentrate, to inhibit the growth of human prostat...rs. This may reflect the ability of isoflavones to inhibit the growth of new blood vessels in the tumor (that is, they have ...Studies of growth hormone result in new class of drugs
...hat concluded earlier this year. "Our antagonists inhibit growth hormone activity in scenarios where excessive growth hormone action may be implicated in a disease," said Kopchick, who added that his work and studies elsewhere suggest growth hormone is involved in the progression of diabetic kidney disease ......protein. As a result, they develop antibodies that inhibit the drug so it no longer works. The only recourse at this point is to give such patients factor VIII from pigs; subtle differences on the surface of the porcine protein can prevent an immune response in a small number of patients. A better alternativ......stones are formed can help physicians learn how to inhibit their formation through medication and dietary changes. This would eliminate the need for invasive treatment for one of the most common diseases of the digestive system. The observation, made possible by the use of two complementary state-of-the-art ...New quit strategy offers smokers more pleasure, less risk
... promising. "In this research we know that if we inhibit the enzyme, if we find a new drug that does that, the concept will work," Sellers said....New horizons, treatments in anticancer chemistry
...ing their structure after they form, cryptophycins inhibit tumor growth by preventing the formation of microtubules. A synthetic cryptophycin analog is in Phase I clinical trials. (Chuan Shih, Ph.D., Lilly Research Laboratories, Indianapolis, Ind.; ORGN 291, Monday, March 27, 4:40 p.m., Moscone Convention Ce...Study links one human gene to multiple diseases of old age
...s, made by cells rendered senescent by p21, either inhibit the death or stimulate the growth of neighboring cells. According to Roninson, this paradoxical growth-stimulating activity of growth-arrested cells resembles the functions of certain cells found in human cancers, suggesting that p21 may be involved ...Dietary bioflavonoids induce DNA breaks, may contribute to infant leukemia
.... The bioflavonoids, like the drugs VP16 and Dox, inhibit the action of an enzyme known as topoisomerase II (topo II), which helps to cleave apart and then rejoin strands of DNA, a process that is pivotal for various cell functions. Leukemia can result when these normal DNA breaks are not properly reconnec...