University of Rochester awarded patent for class of drugs known as cox-2 inhibitors
...rmaceutical companies to identify drugs that would inhibit the action of the enzyme and, in turn, reduce infl...rsa - to enable researchers to identify drugs that inhibit the production of cox-2 without inhibiting the production of cox-1. Several pharmaceutical companie......irudin, thereby enhancing the peptide's ability to inhibit thrombin. Dynamic Changes in Size Distribution of Emulsion Droplets During Ethyl Acetate-Based Microencapsulation Process By Yogita Bahl and Hongkee Sah This study focuses on the dynamic process of the breakup and formation of emulsion droplet...Researchers identify pathway that may slow the progression of Lou Gehrig's disease
...ompanies have compounds under development that may inhibit caspases more specifically. He calls the study "proof of principle" that a caspase-inhibiting drug could help delay onset of symptoms and prolong life in ALS patients. Currently, no treatment exists for ALS. "Virtually all our patients are dying," ...Purdue 'stealth compounds' attack cancer cells
... "Nucleotides can be used in a number of ways to inhibit a specific critical pathway that a cell requires to proliferate," Borch says. "The problem was, we couldn't deliver nucleotides directly into a cell because they carry a negative charge that prevents them from crossing the cell's membrane." Many cu...OHSU researchers discover new synapses in brain
...al used to transmit signals at these synapses, can inhibit the development of these cells into the mature, myelin-producing oligodendrocytes. These newly discovered connections may help answer many remaining questions about how nerve cells regulate myelin formation. While the research team stresses their bas...Selective inhibitor can target specific enzyme that promotes cancer
...tific society. The molecule is able to selectively inhibit gelatinases, enzymes involved in the growth and spread of cancerous tumors, according to Shahriar Mobashery, Ph.D., who headed the research team at Wayne State University in Detroit. It represents the first success in designing a molecule that can sp...Ritalin helps children with ADHD maintain normal reaction time
...t medication improves the ability of ADHD kids "to inhibit inappropriate task skills and prepare for a new task regardless of whether the task switch is frequent and predictable or infrequent and unpredictable," the authors wrote....New Jersey researchers receive national award
...be able to design a small compound that could both inhibit it and be absorbed, not broken down, by digestion," said Ondetti. Previously, researchers took a trial-and-error approach to discovering new drugs. "Their discovery of captopril represented the first example of rational drug design in the pharmaceu...Scientists develop polymers with nitric-oxide releasing particles
...ch produce nitric oxide to relax blood vessels and inhibit blood coagulation. "Our goal is to reproduce the body's natural nitric oxide production system, which prevents clots from forming inside blood vessels," said Mark E. Meyerhoff, U-M professor of chemistry. At the American Chemical Society meeting ...Drug therapy significantly extends lifespan of worms
...oxygen radicals generated inside the mitochondria inhibit mitochondrial function and gradually destroy the mitochondrial DNA, which are the blueprints necessary to keep these power plants of the body functioning. "If you have a power plant that burns coal, you will get energy but also toxic smoke. You ......lations that are resistant to chemotherapy and may inhibit tumor regrowth between cycles," explained Dr. Belani. The study presented today enrolled 214 patients with previously untreated advanced and metastatic NSCLC to determine which of three weekly regimens of induction TAXOL plus Paraplatin was the mos...Virco first to introduce drug-specific biological cut-offs for its HIV resistance tests
...directly in terms of how much drug was required to inhibit the replication of the virus by 50% (the IC50), and then, compared to the IC50 for a laboratory standard reference virus. By repeatedly running a test with the standard reference virus, the reproducibility of the test was measured and a cut-off was ...Impulsiveness, aggression, alcohol and adolescents
...ansmitter serotonin in the parts of the brain that inhibit impulses. Studies of adults with alcohol use disorders have found evidence of decreased serotonin function, especially those with Type II alcoholism (identified by antisocial behavior). Similarly, studies of impulsive-aggressive individuals, indepe...HIV research takes promising new direction
... research," Tor said. "We hope these compounds can inhibit the interactions that allow the HIV to spread. This area is still in the dark ages, so there's plenty of opportunity for progress."...University of Toronto researchers develop potent vaccine for Alzheimer's
...eatments including drugs which block formation and inhibit the toxicity and then a vaccination which will remove the plaque." The researchers believe this study provides the final element of proof that Alzheimer's is initiated by amyloid peptides. "While there are other factors that play a role in the devel...Estrogen has antitumor activity in hormone therapy-resistant breast tumors
...re suggesting that low levels of estrogen may also inhibit the growth of tamoxifen-stimulated breast tumors. ...ssion of Her2/neu and NF-κB, two factors that inhibit apoptosis, and increased expression of the death receptor protein Fas, which regulates apoptosis. C...... needed to know: How does it function? How does it inhibit axon growth? We needed to identify the molecular mechanism of Nogo action," he said. What the researchers found is a receptor on the axons to which the Nogo protein binds. It is this receptor, Strittmatter said, that inhibits the axons regenerative g...Molecules inhibit HIV protease, could lead to new line of attack against AIDS
...ers have identified a molecule with the ability to inhibit a key enzyme of HIV, a finding that could limit the spread of the virus that causes AIDS. The laboratory test results are reported in the February 7 issue of the Journal of the American Chemical Society, a peer-reviewed journal of the American Chemic...Untangling prostaglandin signaling
...ry drugs (NSAIDs) such as aspirin are well kown to inhibit this pathway by blocking prostaglandin biosynthesis, more specific agents would be useful, given the disparate biological responses that prostaglanins mediate. Stock et al. now report the genetic disruption of the PGE2 receptor EP1, one of 4 such re......often controllable using nucleotide analogues that inhibit the viral DNA polymerase, drug-resistant variants often emerge following chronic treatment, as a result of mutations in the nucleotide binding site of this enzyme. Here, Ono and colleagues show that known HBV polymerase point mutants blunt the effec...