Pharmacologist tip sheet: Migraine patches, nicotine therapies, allergy medication interference...
...der scale, grapefruit, orange and apple juices may inhibit the absorption of a broadrange of drugs by inhibiting OATP which would represent a new mechanism of food-drug interaction [Poster PI-82,89] Tracking Adherence AIDS Medication Regimes Physicians concerned about whether their AIDS patients are adhe...Early trial at Thomas Jefferson University Hospital shows Angiostatin is safe
... been given to human beings, especially drugs that inhibit blood flow to tumors without directly destroying tumor cells as occurs with chemotherapy or radiation, is to develop means for determining which patients would benefit from continued treatment,"Dr. Capizzi says. The drug's lack of toxicity was a plea...UCLA-led study first to show green tea helps prevent chronic gastritis
...contains antioxidants that researchers believe may inhibit the development of chronic gastritis and halt the progression of stomach cancer. "This is the first time that green tea drinking was found to protect against chronic gastritis," said principal investigator and lead author Dr. Zuo-Feng Zhang, a prof...UIC Nature paper points to new drug discovery direction
...earchers to understand better how many antibiotics inhibit activity that is critical to bacterial growth. This finding makes sense from an evolutionary perspective, Mankin says. According to the RNA world theory, life on this planet began as RNA molecules that reproduced without protein. Unlike modern cells ...Natural immune response reduces nerve damage; may lead to improved treatment for spinal cord injury
...atural protective autoimmune response, and thereby inhibit the cascade of normal damage that occurs after the initial trauma, such as spinal cord injury. In four experiments in rats and mice, Schwarz and colleagues Eti Yoles and Ehud Hauben found that central nervous system trauma evokes a protective immun...Beta-blocker shown to be ineffective in patients with advanced heart failure
...hrine from being released. Bucindolol's ability to inhibit the release of this hormone and block its receptors may not be well-tolerated in patients with advanced heart failure because of the rate at which the levels of the hormone are dropped. "The failing heart relies on adrenergic support for contracting,...Novel therapy shows promise to prevent recurrance of head and neck cancer
...head and neck cancer to prevent cancer recurrence, inhibit the formation of SPTs and reduce the toxic effects from treatment. This treatment differs from standard chemotherapy in that it mobilizes the bodys immune system to fight the cancer rather than generally poisoning rapidly dividing cells. Forty-four p......y may result from the drugs ability to scavenge or inhibit the production of oxygen free radicals, tissue-damaging chemicals produced during circulatory arrest. Before reconstructive surgery was introduced in the early 1980s, HLHS was invariably fatal in early childhood. Survival rates for HLHS have been i...New recommendations proposed for safe use of herbal medications by patients having surgery
...ications can speed up or slow down the heart rate, inhibit blood clotting, alter the immune system and change the effects and duration of anesthesia. The American Society of Anesthesiologists has recognized the potential for adverse reactions and suggests that patients stop taking all herbal medications t...Duke researchers identify the mechanisms by which drug combinations kill fungal infections
...th cyclosporin and FK506 enter the fungal cell and inhibit calcineurin, which is their well-established target. "We discovered that calcineurin is a component of a fungal stress response that allows the cell to survive assault on the membrane by the azoles. Inhibition of calcineurin cripples this stress resp...Stroke news tips for Friday, Feb. 8, 2002
...g. Researchers conclude that regular exercise can inhibit the formation of blood clots without altering cholesterol levels. Robert N. Gan, St. Lukes Medical Center, Quezon City, Philippines, (61) 8-9224-2598; rgan@info.com.ph . 5:30 p.m. #P150 General public needs stroke awareness education. A statewide...American Chemical Society meets April 7-11 in Orlando
...s to destroy brain tumors, fight osteoporosis, and inhibit coughing; The chemistry of movie production and film preservation; Energy for the future; and Diversity issues in science, including symposia on the advancement of women and the creation of female-friendly workplaces. The American Chemi...USC researchers define role of protein, discover cause of chromosome damage
...ers first author, "is try to screen for drugs that inhibit Artemis, because this might be useful from a cancer therapy standpoint. If we could just give a pulse of drug inhibitor for a while, we might be able to focus the effects of radiation therapy, for instance, by not allowing the cancer cells to repair...Tricking diseases into synthesizing their own worst enemies
...bel Prize. "The very enzyme that you are trying to inhibit was used to assemble the inhibitor." "It works a lot better than we ever anticipated," says Sharpless. The reaction is an example of what Sharpless calls "click chemistry," a methodology for chemical synthesis he invented a few years ago. "The idea [...Novel anti-coagulant clears hurdle
... on the action of anti-thrombin III and is able to inhibit Factor Xa within clots that have already formed. "These properties may make it a superior anti-coagulant," Alexander said. Duke is the coordinating center for all three of the XaNADU trials. XaNADU-ACS is unique in that it is the first clinical trial...Outsmarting cancer - new results from novel enzyme inhibitors
...factors and the nucleus of the cell and appears to inhibit the growth of the cancer cells. In addition, several other proteins involved in cell growth and motility may also be farnesylated and so may also be targets for farnesyl transferase inhibitors. Another key enzyme the 26S proteasome is also in the f...Statins may inhibit calcium growth on aortic valve in the elderly
... may well be that the use of statins could slow or inhibit development of the problem," says Dr. Kevin OBrien, an associate professor of medicine in the UW School of Medicines Division of Cardiology. OBriens co-authors of the research letter include Drs. David Shavelle and Xue-Qiao Zhao, also from the UW Div...New study of coated stent long-term results disappointing
... Italy. Drug-eluting stents contain chemicals that inhibit cell growth in the inner layer of the artery wall. This prevents in-stent restenosis, which can cause a heart attack. In the past, doctors have used lasers, drugs and other techniques to prevent restenosis. In what researchers call the first clin...Green tea extract polyphenol may have a protective effect on Parkinson's Disease
...cate the mechanism, or action, of polyphenol is to inhibit the uptake of dopamine or MPP+ by blocking dopamine transporter (DAT), suggesting that its protective effect in Parkinsons disease is its ability to block the DAT-dependent uptake of environmental neurotoxin. Clinical effects of polyphenol on human P......veral years ago that selective inhibitors of COX-2 inhibit PGI2, but not TxA2. The possibility that such drugs might constitute a cardiovascular risk has since attracted considerable attention. "While such a clinical risk is far from established," said FitzGerald, "our results afford a credible mechanism b...