New drug holds promise to block clots in people with artery disease
...urther investigation of this and other agents that inhibit factor Xa in people with atherothrombosis, ischemic heart disease, and those undergoing coronary bypass surgery. Anticoagulants, or blood-thinning drugs, work by inhibiting the ability of the blood to clot. Blood clots lodged in the coronary arterie...Steroid pill prolongs survival in patients with multiple myeloma
...l survival. Steroids, however, have been found to inhibit tumor growth in multiple myeloma. Prednisone, for example, is a steroid that can be taken in pill-form and has been combined with up front chemotherapy to help shrink tumors and bring patients into remission. The drug has also been evaluated in com...Stroke survivors have brittler bones, more likely to fracture
...ministered early in rehabilitation.Bisphosphonates inhibit cells in the bone called osteoclasts from breaking down bone tissue. The drugs, given intravenously or taken orally, have been used to treat osteoporosis in postmenopausal women. Poole says the intravenous form of the drug would most likely have ...Steeped in research: Tea linked to survival after heart attack
... coronary heart disease, he says. Flavonoids also inhibit the oxidation of low-density lipoprotein (LDL). Oxidized LDL may promote atherosclerosis, so this property of tea may help prevent additional heart attacks, at least in some patients. In addition, flavonoids could have an anti-clotting effect. Stud...Contraceptive needs of new mothers are unique and unmet
...ly important that the ideal contraceptive does not inhibit enjoyment of sex, and 35 percent state that this is more important to them now than prior to pregnancy. Hassle-free A vast majority (90 percent) of new mothers agree that the ideal method of birth control is hassle-free, and many (40 percent) repo...A caring mother is a childs best defence against drug culture
...findings suggest that living with both parents may inhibit drug use but only if availability through peer networks is not very high. They also suggest that attachment, particularly to mothers, is a more potent inhibitor and that this is truly across cultures and substances. This tends to break down only in ...GlaxoSmithKline Drug Discovery and Development Award 2002
...h to facilitate testing of chemical compounds that inhibit HIV integration into human T-cells; Erwann Loret, ...o the development of a new class of drugs that may inhibit the viral protein; and Linqi Zhang, Ph.D., Aaron Diamond AIDS Research Center, New York City, for wo...Molecularly targeted drug slows tumor growth in patients
...ging, demonstrating that anti-angiogenic drugs can inhibit tumor growth in patients," said James C. Yang, M.D., of NCI's Center for Cancer Research, the lead investigator on the study. "This is an important first step toward validating, in patients with cancer, the exciting advances in angiogenesis we have ...Studies yield key insights in preventing destruction of insulin-producing cells
... molecules. In fact, the antibody may selectively inhibit previously activated immune cells that are involved in the development of diabetes," said senior author, University of California at San Francisco's Dr. Jeffrey Bluestone. Dr. Bluestone developed the monoclonal antibody in the 1980s in collaboration...130-year-old mysteries solved: how nitroglycerin works; why patients develop tolerance
...ed for sleep disorders and acetaminophen (Tylenol) inhibit mALDH activity,"he said. "For that reason, heart patients who take nitrate drugs such as nitroglycerin may dobetter if they did not take those drugs." In addition, alcohol will interfere with nitroglycerin, so these patients probably shouldn'tdrink,...Choose your painkillers with care
...ad some form of bone regrowth. Traditional NSAIDs inhibit the enzymes cox-1 and cox-2. Cox-2 catalyses the production of hormone-like chemicals known as prostaglandins involved in inflammation, while cox-1 has a variety of roles not specific to the inflammatory response. Since the new generation of NSAIDs s...New treatment for skeletal metastases
...mour spreads to skeletal tissue, and that it might inhibit metastases. This would have an effect on pain and quality of life and could increase survival. It is still too early to tell whether such treatment might offer a cure if administered early enough", adds Balteskard....New method of turning off viruses may help control HIV infection, says Jefferson scientist
...material called short interfering RNAs (siRNAs) to inhibit HIV from making more copies of itself. The process, called RNA interference (RNAi), was first discovered in 1998. It is so novel, says virologist Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and chief of t...Drug resistance may prove more pervasive in African HIV
...e most important drugs currently used to treat HIV inhibit two key enzymes in the life cycle of the virus, protease and reverse transcriptase. Mutations in these enzymes can reduce the inhibitors' abilities to form a tight association with them, leading to drug resistance. The new report builds on a pr...Schepens is recipient of the most National Eye Institute funds in 2001
...py, angiogenesis and the use of small molecules to inhibit eye inflammation are just some of the efforts underway. Innovative new devices to help compensate for vision loss and improve quality of life are also being developed and tested at The Schepens. According to Streilein, every one of the 28 laboratory ...Aspirin's target, the COX-2 enzyme, linked to cancer of the uterus
... nourishment to the lesions. Currently, drugs that inhibit COX-2 are prescribed in the treatment of precancerous polyps in the colon and colon cancer, where cells have increased levels of the enzyme. In previous research, Bulun found that the prostaglandins manufactured by COX-2 stimulate the production of e...Drug targets brain circuits that drive appetite and body weight
...echanistic explanation of how drugs like D-FEN may inhibit food intake. Investigating the neurobiology of drug-caused anorexia may lead to the development of new drugs with fewer side effects to prevent and treat obesity," Elmquist stated....Discovery may lead to new HIV drugs, says Jefferson virologist
...s or macrophages without it," he says. "If you can inhibit Vif, or stop it from inhibiting the CEM15 protein, you have a great antiviral," says Dr. Pomerantz, "Nothing in HIV will be infectious." Much work lies ahead. Researchers, for example, still don't know exactly how Vif works. But learning how to stymi...Reducing side effects of retinoic acid cancer treatment
...cell can dramatically enhance the ability of RA to inhibit the proliferation of breast cancer cells, so that ...pread of cancer cells, and some, including RA, can inhibit tumor growth by preventing cancer cell proliferation. Retinoids are now in clinical trials for treat...Honey fights cholesterol as well as some fruits and vegetables
...phenolics." Phenolics are chemical compounds that inhibit oxidation. Higher phenolic contents in foods tend ... Illinois at Chicago to evaluate honeys ability to inhibit oral pathogenic bacteria, like Streptococcus mutans (S. mutans) , which can cause tooth cavities. "...