Blocking pathway overcomes tumor vessel resistance to radiation
...p clinical trials using these or similar agents to inhibit the PI3K/Akt pathway in conjunction with radiation therapy. Wortmannin is in clinical trials already, though not yet with radiation, Hallahan said.It is expected to be at least a year before such clinical trials are ready to begin....Eating soy during adolescence may reduce breast cancer
...ize. And some studies show that genistein seems to inhibit some enzymes that are important in metabolizing estrogen. Regardless of the protective mechanism, Wu notes that if the mounting soy research shows promise, many may ask, "How much soy is enough?"There may be a point at which eating more soy does not ...Can an aspirin a day keep atherosclerosis at bay?
...ry molecules such as lipoxins, which in turn could inhibit the formation of cytokines the very molecules that may stimulate atherosclerosis. While Pratic recognizes more research needs to be done, aspirin could provide a potent, and inexpensive way to fight atherosclerosis. Low-dose aspirin has already bee...Duke researchers develop method to make safer drugs
...se RNA) that bind directly to a target protein and inhibit the protein's activity. Researchers expect that aptamers have the potential to be the key to developing a new class of drugs. "We theorized we could neutralize the aptamer by using small nucleic acids that could be paired with the aptamer, much like...GlaxoSmithKline Drug Discovery and Development Award 2002
...lopment of second- and third-generation drugs that inhibit that enzyme; Alan C. Sartorelli, Ph.D., Yale Unive...lly sees the host cell, so we can determine how to inhibit its binding to the cell," said Dr. Chaiken, research professor of medicine at the University of Penn...Blocking enzyme found to ease anxiety without causing sedation
...ning their immune function. But a drug designed to inhibit PKC epsilon might well avoid this side effect, since it would not knock out all enzyme function, Messing noted. "Although we don't yet know precisely how PKC epsilon normally affects GABA-A receptors, the research clearly shows its effect on anxiety-...Researchers find promising new target for anxiety-reducing drugs
...d, medications could be developed that selectively inhibit PKC epsilon and modulate GABA differently from the existing imperfect drugs such as benzodiazepines with their sedative and addictive side effects. "We don't know that yet, but this work gives us new hope," the scientist said. In an accompanying co...Study shows why some immune systems control HIV
...ogy. Instead of attacking HIV directly, CD8+ cells inhibit virus spread by killing off other immune system cells infected with HIV. "For some time we have known that even patients who cannot control HIV maintain high numbers of HIV-specific CD8+ T cells," says senior author Mark Connors, M.D., of NIAID's La...OSU cancer researchers win $9.5 to study immunity
...tokines hormone-like substances that may either inhibit or promote anticancer activities. Accordingly, all trial participants in the trials will receive a new biologic therapy, rituximab, plus the addition of either interleukin-2 or etanercept, agents that may affect rituximab's efficacy. Other new anti...Research on cells' 'power centers' sheds light on AIDS treatments
...ated that current AIDS treatments using drugs that inhibit HIV proteins also could inhibit a key mitochondrial protein.This speculation fits the observation by doctors that side effects resem...Lauder supports James nutrition and breast cancer study
...study soy and tomatoes as dietary factors that may inhibit breast cancer. The new study will enroll 140 pre-menopausal women who will be randomized to either a low fat or a low sugar diet for one year. Participants in both arms will be encouraged to exercise and will be monitored for changes in a number of ...Angioplasty safer, need for emergency surgery afterward plunges
...cian experience, improved techniques, new drugs to inhibit clot formation, and technological advances such as stents, which help keep arteries open. "Among the patients who did not require emergency bypass surgery, there was a significant decline in the incidence of death and heart attacks from 1992 through...OHSU takes part in unique Alzheimers treatment trial
... named LY450139, which in mouse models is shown to inhibit an enzyme implicated in the formation of beta-amyloid deposits in the brain. These deposits, also called plaques, may be responsible for brain cell death and decay, and have been connected to Alzheimer's disease. A total of six sites in the United St...New strategy may protect brain against stroke, Parkinson's and Alzheimer's
...lpha (PFT), which was shown in previous studies to inhibit p53. They then designed, synthesized and tested analogues of this compound to see whether they would work against cultured brain cells and animal models of neurodegenerative disease. In laboratory tests, brain cells exposed to a series of toxic chemi...Prostate cancer program at UCLAs Jonsson Cancer Center designated a site of research excellence
...r will focus on developing targeted therapies that inhibit the growth of prostate cancer. Their laboratory st... shown that a low-fat diet and omega-3 fatty acids inhibit the growth of prostate cancer cells in test tubes and in animal models. Human studies will focus on ...Mild injury may render brain cells vulnerable to immune system attack
... The scientists believe that drugs to selectively inhibit the immune proteins could reduce the rate of neural damage in a wide range of neurodegenerative diseases. Such drugs could also protect other organs against damage from autoimmune diseases such as lupus and rheumatoid arthritis, in which the immune s...Cholesterol drug could lead to new therapy for multiple sclerosis
...emonstrated that lovastatin and some other statins inhibit the production of certain pro-inflammatory molecul...rosis. Other studies suggest that some statins may inhibit molecules that kill nerve cells, which can occur in the later phases of some forms of the disease. T...Flaxseed-rich diet blocks prostate cancer growth and development in mice
... progression of prostate cancer, lignan could help inhibit the growth and development of the disease. In the Duke study, 135 mice genetically engineered to develop prostate cancer were divided into a control group and an experimental group. The experimental group received a regular mouse diet, but 5 percent ...Trial opens new possibilities for improving survival with a novel heart attack drug
...or the trial was to use this very targeted drug to inhibit a particular part of the complement cascade to dec...drug is particularly appealing because it seems to inhibit the complement cascade at a point where the ability to fight infection is preserved but the negative......ut that the concentrations of imatinib required to inhibit cell proliferation and to block c-kit activation suggest that c-kit is not the primary target of imatinib and that such high concentrations may not be achievable in the clinical setting. The promise, he concludes, is that identification of another i...