Targeting bone metastasis and hypercalcemia
... San Antonio, Texas) identified two compounds that inhibit PTHrP production in human breast cancer cells. In ...o classes of drugs is different--the new compounds inhibit PTHrP production and secretion by the tumor cells whereas bisphosphonates inhibit osteoclasts--which...Soaking in the genius of Mother Nature
...cer and AIDS, where they have shown the ability to inhibit HIV integrase and thereby control the disease, lamellarins, like many naturally occurring substances of their ilk, are difficult and expensive to come by. The most obvious problem is that ripping up chunks of coral reef to secure marine sponges is il...UCB's pharma sector announces promising first results of a new antiepileptic drug candidate
...cb 34714 were assessed by examining its ability to inhibit kindling in mice. Kindling is a process of brain ...s shown to have a potent and persistent ability to inhibit corneal kindling development. This supports that ucb 34714 may possess potential for improving epile...Colonoscopy far more cost-effective against colon cancer than promising Cox II drugs, study predicts
..., like aspirin and ibuprofen, can create when they inhibit both kinds of cyclooxygenase. Those two properties have made the drugs attractive for treating chronic joint disorders, and have raised hope that they could be effective against cancer. Already, the U.S. Food and Drug Administration has approved the...UNC physician says patient, doctor education improves health outcomes
...y recommendations at once and patient anxiety also inhibit patient recall. Having another family member present often aids communication, as does a closely scheduled follow-up visit.Doctors and other health providers should use plain language with patients, stress only the most important recommendations and......icrobials" - natural substances added to food that inhibit the growth of harmful microorganisms. He and OSU research assistants Karl Schilke and Cindy Bower have completed research indicating that ground up raisins work just as well as the preservative sodium nitrite, typically used as a processed meat prese...OneWorld Health licenses compounds from Yale, U of Washington to treat major parasitic diseases
...the parasite Trypanosoma cruzi (T. cruzi). Azoles inhibit production of a chemical that is necessary for the survival of T. cruzi without harming human cells. The parasitic disease is contracted through insects widely known as "vinchuca," "barbeiro," and "chipo," in addition to the "kissing bug." (photo at ...Interferons for treatment of SARS?
...drich Cinatl comments: "We showed that interferons inhibit SARS-CoV replication in vitro. Interferon beta was most potent, showing prophylactic protection and antiviral potential after infection. Interferon beta could be the drug of choice, alone or in combination with other antiviral drugs, in the treatment...Researchers link the plaques and tangles of Alzheimer's disease
...servation that one end of the tau protein seems to inhibit the formation of tangles in vitro, Lester I. Binder and Vincent L. Cryns, of the Feinberg School of Medicine at Northwestern University, investigated the possibility that caspases might target tau during apoptosis, removing the end fragment and causi...JCI table of contents, 1 August 2003
...ant form of PAI-1, known as PAI-1R, which does not inhibit ECM breakdown, resulted in increased matrix turnover and reduced glomerulosclerosis in rats. "The studies of Noble and her colleagues show us that modulating fibrosis is a goal within reach, and inhibition of these mechanisms could confer benefits be...Green teas cancer-fighting allure becomes more potent
...hemicals that make up green tea and found two that inhibit AH activity. The two substances, epigallocatechingallate (EGCG) and epigallocatechin (EGC), are close molecular cousins to other flavonoids found in broccoli, cabbage, grapes and red wine that are known to help prevent cancer. While green tea has be...New compound that acts on peripheral receptors may be treatment for some nerve pain
...ot yet been found there; it may act in some way to inhibit the release of chemicals like prostaglandins from immune cells that increase sensitivity to pain; or they may cause immune system cells to release substances that block the pain response." AM 1241 was developed by Dr. Makriyannis....Decrypting the role of Cripto in tumor growth
...ncer, and that this correlates with the ability to inhibit Activin signaling. The study suggests that Cripto overexpression may play an early role in cancer progression through the inhibition of the tumor supressing effects of Activin. In an accompanying commentary, Michael Shen from the University of Medici...UCSD researchers ID peptides that bind to Alzheimer's plaques
...st, they could be coupled to molecules designed to inhibit the toxicity of beta-amyloid plaques. The peptide...tances that stimulate the breakdown of plaques, or inhibit them from forming. A final application would be coupling the peptides to other markers that would h...Stanford researchers study new antiviral approach to protect women from HIV
...lthy vaginal mucosal linings - could significantly inhibit the ability of HIV to infect cells. Their findings are published in the Sept. 8 advance online edition of the Proceedings of the National Academy of Sciences. Lee said that if the strategy works as well in humans as it does in cells, it may someday p...Imaging study reveals effect of smoking on peripheral organs
...oses the entire body to the tobacco compounds that inhibit MAO B, we believed it had the potential to limit MAO B activity throughout the body," said Fowler, who conducted the current study to investigate this effect. She and her colleagues in the Medical and Chemistry Departments at Brookhaven Lab and the P...Lotion made from tea could help fight skin cancer
...nds, which are found in both black and green teas, inhibit a newly discovered chemical pathway involving an .... Dong does not know yet if the tea chemicals will inhibit melanoma, the least common but most deadly type of skin cancer. More studies are needed, he adds. Do...Comfort-food cravings may be body's attempt to put brake on chronic stress
...e researchers suspect that the metabolic signal to inhibit the stress system comes directly from fat depots. The finding offers an explanation into how chronic stress can be inhibited, or curbed. While the body's acute response to stress - say to being cut off in traffic by a speeding car - diminishes throug...Cranberry component linked to reduced stroke damage
...ame unique bacteria-blocking ability may also help inhibit stomach ulcers and even gum disease. While the data on stroke remains preliminary, a great deal of evidence shows that a daily dose of cranberry is a smart addition to the diet for many reasons. Dr. Starr noted, "Researchers from several world class ...Sphingosine kinase inhibitors may hold key to halting growth of some tumors
...e first 'drug-like' agents that have been shown to inhibit an enzyme called sphingosine kinase," said Charles D. Smith, Ph.D., professor of pharmacology, and director of the Drug Discovery Core, Penn State College of Medicine. "Since sphingosine kinase is involved in growth regulation and certain other biolo...