Other highlights in the September 17 issue of JNCI
... and colleagues used antisense oligonucleotides to inhibit hMYCN expression in mouse models of neuroblastoma. Mice treated continuously with antisense oligonucleotides had a lower incidence of neuroblastomas and lower mean tumor mass than mice treated with control oligonucleotides. "Our results raise the pos...Roche pledges continued support for Organ Transplantation Research Foundation
...e of transplantation immunology is to specifically inhibit the body's response to the graft while leaving the remaining immune defence system unaffected and so ensure long-term survival with minimum side effects. Award-winning projects, newly funded by ROTRF in 2003, include research to understand the body'...Neurons that play truth or consequences
...followed instructions. By requiring the monkeys to inhibit a movement after their brain had begun preparing to execute it, Schall and his colleagues created situations that isolated different types of neural signals. By recording in the ACC while the monkeys responded to these situations, the researchers suc...Rejection really hurts, UCLA psychologists find
...esearchers theorize that the prefrontal cortex may inhibit the cingulate as opposed to the other way around. "Verbalizing distress may partially shut down areas of the brain that register distress," Lieberman said. "The regulating abilities of the prefrontal cortex may be why therapy and expressing painful f...Alzheimer's Association cautious about new Alzheimer treatment research with antibiotics
...me laboratory studies have shown that rifampin may inhibit the buildup of amyloid. Studies in animals have shown that therapeutic strategies aimed at reducing amyloid aggregation may be effective in reducing amyloid pathology....More than $34 Million in SPORE Grants
... kinase inhibitors that is designed to selectively inhibit an enzyme involved in the development of the disea...of BCR/ABL by developing therapeutic strategies to inhibit transcription of this oncoprotein investigate the role of PPARg a nuclear transcription factor its...Use of statins may prevent breast cancer, say University of Pittsburgh researchers
...wn for years that cholesterol inhibition serves to inhibit tumor cell growth, our analysis is one of the first to look exclusively at the relationship between lipid-lowering medications and the development of breast cancer, and our findings are dramatically positive," said study author and lead investigator ...NIAMS researchers collaborate to produce targeted immunosuppressant drug
...d safely in humans. Immunosuppressant drugs, which inhibit the body's immune response, are given to prevent the body from rejecting transplanted organs, and are also used to treat autoimmune diseases such as lupus, rheumatoid arthritis, eczema and psoriasis. Autoimmune diseases cause the immune system to att...Studies show Tim-3 proteins key to immune responses
... surface of a select group of T-cells functions to inhibit aggressive immune responses could have important implications for organ transplant patients and patients with autoimmune diseases, and could prove equally relevant in the development of vaccines for the treatment of cancer, drug-resistant tuberculosi...Whole tomato powder effective in preventing prostate cancer
Whole tomato power--but not lycopene alone--may inhibit the development of prostate cancer, according to a...ontain components in addition to lycopene that may inhibit prostate carcinogenesis," the authors write. They say that more work is needed to understand the rol...Scientists map maturation of the human brain
...showed significant improvement in their ability to inhibit a motor response following acute nicotine administration. Nicotine produced a short-term improvement that was as large as the improvement seen after giving them Ritalin, the standard drug used to treat ADHD, says Alexandra Potter, PhD, of the Univers...Several commonly used pesticides are toxic to mitochondria in laboratory experiments
...daben, fenazaquin, and fenpyroximate, all of which inhibit complex I. Pyridaben was by far the most potent toxic compound, followed by rotenone and fenpyroximate, with fenazaquin being the least toxic. Pyridaben was also more potent than rotenone in producing "free radicals" and oxidative damage to the cel...Antidepressants decrease chronic pain by inhibiting TNF production in brain, UB researchers find
...yline in treating pain stems from their ability to inhibit the production of the inflammatory protein tumor n...s from back injury, may make neurons that normally inhibit pain when exposed to norepinephrine actually enhance pain in the presence of norepinephrine," said S...Parasite lipids against asthma or diabetes
...ated that lipids from the parasite schistosoma can inhibit human immune responses. This property makes the li...sponses to certain substances. Molecules which can inhibit the immune responses, such as the lipids of schistosomes, could be used to suppress these errant res...Salk news: Diabetes first steps
...ny and his team suggest that a chemical that could inhibit the actions of CREB under diabetic conditions might lead to drugs that provide a more effective diabetes therapy. These chemicals could possibly be used in combination with a group of drugs called TZD's (thiazoladine diones), now used to make the bod...Implanted stimulator for Parkinson's disease impairs cognitive function
.... "When a number would appear, they had to try to inhibit the natural tendency to press the button," Hershey says. "Stimulation interfered with that inhibition -- when stimulators were turned on, people had a harder time stopping themselves from pressing the button when they weren't supposed to." Hershey s...Interracial interactions are cognitively demanding
...e an unrelated cognitive task in which they had to inhibit instinctual responses. In a separate fMRI session, these individuals were presented with photographs of unfamiliar black male and white male faces, and the activity of brain regions thought to be critical to cognitive control was assessed. "We found...Novel delivery system devised for toxoplasmosis treatment
...crobial effect comes, in part, from its ability to inhibit enoyl reductase. The problem, however, has been how to get triclosan to the parasite. Even in its active stages, T. gondii live in the host's cells and are inaccessible to drugs. But soon after infection, many of the parasites enter a latent stage,...New evidence links inflammation to venous disease
...timate goal of his research is finding new ways to inhibit clot formation in his patients by using an anti-in...reat it. Just stopping inflammation alone will not inhibit thrombosis. You have to target the interaction between inflammation and thrombosis, which is why we ...Experimental drugs reduce neuron death in rats following insulin shock
...that floods cell nuclei when DNA is damaged -- can inhibit these destructive pathways. To test whether they can also protect brain cells from insulin shock, he and his team examined the effects of the drugs in brain cell cultures derived from mice, as well as on rats subjected to induced hypoglycemic coma. I...