Tag: "inhibited" at medical news

Epstein-Barr virus protein crucial to its role in blood cancers

...t the growth of EBV-associated cancer cells can be inhibited in tissue-culture assays. The investigators are actively pursuing this line of investigation for developing potential therapies....

Study: Two brain systems regulate how we call for help

... research, we showed that some monkeys will become inhibited and freeze when they're frightened, especially when a predator is nearby and the monkey believes that it hasn't yet been discovered by the predator," Kalin says. "We observed that the greater the fear, the less likely it was that animals would call f...

Stem cell therapy for spinal injury

...other genes during the stem cell maturing process, inhibited the development of astrocytes and encouraged the formation of oligodendrocytes, another type of glial cell that forms the fatty myelin sheaths around the axons. The small number of astrocytes that developed from the neurogenin-2-bearing stem cells co...

Genes in the interferon system important in SLE

...yrosinkase protect against SLE. It probably has an inhibited function that blocks the interferon effect. It is therefore possible to imagine the development of methods of treatment for SLE based on blocking the function of the thyrosinkinase enzyme," explains Lars Rnnblom. The other gene codes for a transcript...

Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy

...f these methods reduced melanoma cell survival and inhibited tumor development. Robertson's team confirmed this using a mouse model, finding that decreasing Akt3 activity using siRNA or reintroducing the missing PTEN protein halted tumor progression. "Identifying Akt3 as a possible target to halt the growth o...

O Christmas tree: Your bark may fight arthritis

...vity. The extract (at 50 g/mL concentration level) inhibited nitric oxide production, an excess of which has be...se, they found that the same extract concentration inhibited prostaglandin production, an excess of which has been linked to arthritis and pain, by up to 77 perc...

Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth

... "These results show that tumor growth was greatly inhibited in rats treated with hsFlt3L and reflect an ongoing battle between the tumor and the immune system," said Dr. Castro. "In other words, hsFlt3L stimulated an immune response as evidenced by an increase in the number of dendritic cells in the brain and...

New drug protects against the hardening of arteries

...in levels. In contrast, lesion development was not inhibited by a PPARbeta agonist. In an accompanying commentary, Peter Tontonoz and Antonio Castrillo from the University of California, Los Angeles discuss the mechanism described by Li and colleagues by which lipid accumulation is reduced by these agonists, ...

New compounds effective against Alzheimer's disease onset and progression

...and co-researchers found that the aminopyridazines inhibited both oxidative and inflammatory cytokine pathways and reduced human amyloid beta (Ab)-induced glial activation in a mouse specially designed to develop many of the hallmarks of Alzheimer's disease pathology, including neuroinflammation, neuronal and ...

HIV-1 protease inhibitors: Effective against malaria?

...ilable online. The study found protease inhibitors inhibited the growth of P. falciparum, the malaria parasite ...lciparum. Saquinavir, ritonavir, and indinavir all inhibited parasite growth in vitro at levels routinely achieved in human patients, with saquinavir and ritonav...

Several new techniques show promise for spinal cord repair

...am-treated rats and exposed them to molecules that inhibited nerve regrowth. They found that if cyclic AMP (cAMP)--a molecule found in every cell in our bodies--was elevated in nerve cells, the blockers of growth did not inhibit regeneration. The drug Rolipram blocks an enzyme--phosphodiesterase (PDE)--that br...

New insights into hormone therapy highlight when estrogen best aids brain

...hibit neuronal death, suggesting that progesterone inhibited the neuroprotective action of estrogen in this mod... of the neuroprotective actions of estrogen can be inhibited by progesterone," says Pike. "When these results are applied to the human condition, these findings ...

Tea could improve memory, study shows

...mented. They found that both green and black tea inhibited the activity of enzymes associated with the develo..., but coffee had no significant effect. Both teas inhibited the activity of the enzyme acetylcholinesterase (AChE), which breaks down the chemical messenger or ...

Binge drinking: red wine and alcohol have different effects on platelets

...of alcohol both increased platelet aggregation and inhibited platelet adhesion to fibrinogen-coated surface und...eaking, excess platelet aggregation is bad whereas inhibited platelet adhesion tends to be good. "Platelet adhesion, rolling platelets that stick to a vessel wa...

Mechanism found that 'protects' aggressive melanoma from angiogenesis inhibitors

...ndothelial cell growth and migration were markedly inhibited by anginex, TNP-470 and endostatin, while the melanoma cells were relatively unaffected. The scientists subsequently investigated whether endothelial cells and melanoma cells expressed different levels of two newly discovered recept...

New technology blocks gene to increase immune response against deadly brain tumor cells

...ipheral blood cells. Suppression of the IL-10 gene inhibited the secretion of the IL-10 protein, which allowed increased production of IL-12. Nave T cells co-cultured with siRNA-treated dendritic cells developed into Th1 cells and generated a strong immune response in lab studies. Keith Black, MD, director o...

Duke scientists identify new way to block blood vessels that feed cancer growth

...nimals with cancer. In doing so, they successfully inhibited blood vessel growth in tumors and, thereby, the growth of tumors themselves. The Duke scientists hope to test this potential new therapy plus radiation in humans within the very near future. Results of their current findings are reported in the May, ...

Studies indicate healthy eating may affect cancer development, improve digestive system

...otic protein levels. Treatment of cells with EGCG inhibited cell growth and caused signs of early apoptosis at 24 hours. Further studies found that EGCG significantly increased levels of active caspase-3 and cleaved PARP proteins. "Research suggests that drinking green tea may be both a valuable chemoprev...

Risk factors identified for persistent post-shingles pain

...the antiviral therapy administered in both studies inhibited the spread of the virus and reduced the duration of pain, it did not prevent PHN from occurring in some patients. In the combined data, older age, female sex, presence of symptoms before the rash appeared, severe acute pain, severe rash and extent of...

Newly-described route to cancer solves a mystery in lung cancer

...umor suppressor genes including FUS1 that not only inhibited tumor growth and metastasis, but induced human lung cancer cell death. Still, people who have lost one copy of their FUS1 gene at 3p21.3 have an active copy on their intact chromosome, but for reasons unknown as yet, the now-described defect in myris...

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