NIAID Stops AIDS Study Prematurely Because Drug 'Cocktail' Boosts Survival
...not infectious. Drugs such as ZDV and 3TC work by inhibiting an enzyme called reverse transcriptase. That enzyme enables the virus' genetic material, or RNA, to convert human genetic material known as DNA into more virus. The Food and Drug Administration approved use of the combined ZDV and 3TC in November 19...Cattle: Latest Weapon In The War On Cancer?
...arGAGs in bovine cartilage that do the best job of inhibiting cancer spread. "The reason we believe cattle are such an important source is that,so far, nobody has succeeded in synthesising these compounds. That meansthe supply will continue to rely on natural sources. "Shark fishing is probably an unsustaina......States, appears to act across the pain spectrum by inhibiting the pain signalstransmitted by glutamate, Basbaum says. Morphine is not used as much as itshould be, according to Basbaum, often because of misplaced worries about itsaddiction potential in pain patients. Physicians need to better understand...Drug's Effect On Chromosomes May Explain Second Cancers
... They then incubated the fragments with onetopo-II inhibiting drug after another. Initially, the results were negative. “We got discouraged when we found that topo II didn’t act ontelomeres,” said Muller. Eventually, they tested etoposide. “Itwas positive beyond all belief. It knocked our s...Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
...te and promote weight gain, while at the same time inhibiting pathwaysthat have the opposite effect. These dual responses maximize the body's tendencyto find a physiological balance (homeostasis), and consequently maximize theefficiency of the body in replenishing depleted fuel stores. "While such a rob......uction. PPARa inhibits the inflammatoryresponse by inhibiting the NFkB transcription pathway. This anti-inflammatory action of the fibrates has been confirmed in humans. Theresearchers compared two groups of 19 patients with mild hyperlipidemia. Onlyone of the groups had coronary occlusion, and their plasma con...Drug Reduces Heart Attack, Death Rates In Patients With Unstable Angina
...unstable angina. Researcherssaid the drug works by inhibiting the receptor that causes platelets to bindtogether and form a clot. While aspirin works through a similar mechanism, itonly inhibits one of many pathways leading to the receptor, whereas Eptifibatideinhibits the receptor itself. Another current treat...WFU And IntraVec To Develop Innovative Cancer And HIV Treatments
...n preventing HIV infection ofcells, rather than on inhibiting HIV replication in already-infected cells, asdoes most current treatment. Also, he said, the new technology is less likelythan current drug therapies to have toxic side effects and generatedrug-resistant HIV mutants. Recent data indicate that...Substance Discovered That Induces Hair Follicle Formation In The Mature Skin Cells Of Mice
...o a potential tool to stop unwanted hair growth by inhibiting the pathway. It could also have applications in the agricultural industry, for example to engineer sheep with denser wool or thicker skin, Fuchs explains.......signed to mimic the positive effects ofestrogen by inhibiting bone loss in postmenopausal women, while avoiding ...al women, the drug is less potent than estrogen in inhibiting boneloss and does not prevent hot flashes. Signal is developing new classes of small molecule drugs...UK Allied Health Professor Receives Patent On Using Lithium With AIDS Drugs
...lactually reduce the amount of infectious virus by inhibiting a process that isessential for viral life-cycle," Gallicchio said. The clinical trials for this study will start this year at theUniversity of Potchefstroom in South Africa. The new treatment is being testedin South Africa because AIDS infec......ord injuries. Filbin has found a way to block the inhibiting function of the molecule MAG(myelin-associated glycoprotein) and all other inhibitors present in themyelin sheath that prevent the spinal cord from regenerating after injury.Her findings are reported in the January issue of Neuron magazine,published ...New Drug For Recurrent Brain Tumors In Tests At UNC
...gas on their ownfire," Ewend says. "By blocking or inhibiting that receptor, we might inhibitthe cell's ability to grow." The drug is administered intravenously. Initially, patients will get a doseevery day for four days and then once a week for up to a year. Patients with agood response can continue on the med...Improved Ritalin™ Offers Smaller Doses And Fewer Side Effects
...iterature, which have a ten to one selectivity for inhibiting cocaine withoutinterfering with dopamine," claims Winkler. "And, we have just started ourstudies," he adds. While synthesis of the improved form of Ritalin for treatment of ADHD isready for commercial scale-up, Winkler says, the anticocaine por...Penn Researchers Find Chemoembolization Effective For Liver Tumors
...es that cutoff the blood supply to the tumor, thus inhibiting cancer-cellgrowth. Colon cancer that has metastasized, or spread, can bemanaged with chemoembolization when systemic chemotherapy hasfailed. "Chemoembolization hones in on the cancerous cells thathave spread to the liver and avoids exposing the rest ...Postmenopausal Women Reap Heart Benefits From Foods Containing Vitamin E
...mins in foods might be better than vitamin pillsin inhibiting LDL oxidation, thus protecting against heart disease and stroke. In this observational study, the women listed everything they ate and thevitamin pills they took for six days. During this period, their intake ofvitamin E was measured. LDL oxidation...AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals
... by untreated control animals. AVANT believes that inhibiting CETP has great potential to be a safe andeffective strategy for preventing coronary artery disease. AVANT cites theexistence of a well-studied human population in Japan which congenitally lacksfunctional CETP. Individuals with this genetic mutation...New Anti-Inflammatory Drug Is Easy On The Stomach
...en is that you can getanti-inflammatory effects by inhibiting COX-2, but you decrease or prevent thedevelopment of gastrointestinal tract injury by sparing COX-1." In April, a Food and Drug Administration advisory committee recommended approvalof rofecoxib for treatment of osteoarthritis and acute pain. The bra......port messages fromthe brain to body parts, thereby inhibiting body functions and movement. Thiscan result in a variety of symptoms that range from numbness in the limbs tocomplete paralysis. Approximately 120,000 MS patients in the U.S. have a form of the diseaseclassified as secondary progressive. Th......ndent precocity, and we now know that they work by inhibiting differentparts of the hormone-producing pathway th...dition, Auchus said, now that they have shown that inhibiting this oneenzyme can influence sex hormone production, 3bHSDII may turn out to be a goodtarget enzyme ...