Tag: "inhibitor" at medical news
First head-to-head study to compare lidoderm patch and Celebrex in treating pain
...Due to safety concerns regarding the entire COX-II inhibitor
class in the fall of 2004, the sponsor of the study, Endo Pharmaceuticals Inc., voluntarily elected to prematurely halt the study prior to reaching the original enrollment target. However an analysis of data after six weeks of treatment showed that ...
Study shows patch therapy may be as effective as oral medications
... recent safety concerns regarding the entire COX-2 inhibitor
class, the sponsor of the study, Endo Pharmaceutic...nd drug-to-drug interactions. Celebrex is a COX-2 inhibitor
indicated for the treatment of arthritis pain including OA....
International breast cancer prevention study launches in the United States and Canada
...linical trial to evaluate the role of an aromatase inhibitor
in the prevention of breast cancer. Coordinated by the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG), the ExCel research study will examine the potential benefit of exemestane and its ability to prevent breast cancer in wome...
Fat may promote inflammation, new study suggests
...n that promotes blood clots (plasminogen activator inhibitor
1). These proteins are all manufactured by fat tissue and involved in atherosclerosis, the buildup of fatty deposits in the linings of blood vessels. In addition, the scientists also looked at two "good" proteins, leptin, which regulates energy metab...
2005 Basic Research in Periodontal Disease Award
...p aims to determine molecular targets for protease inhibitor
design using a genome-screening approach. In the case of bacterial virulence determinants, glycosylation is likely to play an important role in interactions of the pathogen with the host. Research in this area examines the genetic machinery of glycos...
Women less likely to get quality heart attack care
... beta blockers, cholesterol-lowering drugs and ACE inhibitor
drugs for patients leaving the hospital. It also seeks to increase the number of patients who get counseling about diet and smoking before they leave the hospital. Sandeep Jani, MPH, the researcher who will present the results, notes that on the whol...
Opportunity missed: TIA patients receive less aggressive attention than those with stroke
...coagulant therapy was similar in both groups. ACE inhibitor
therapy was prescribed in 26 percent of stroke patients and in 12 percent of TIA patients. The rate of documented stroke education at discharge for TIA patients was 35 percent versus 67 percent for stroke patients. In light of the findings, Dandapa...
COX-2 inhibitor increases the risk of heart attack in elderly adults with no history of heart attack
...senior citizens. Only one of these agents, a COX-2 inhibitor
called Vioxx--a new class of NSAIDs--carried a greater risk of heart attack. "Many believe that COX-2 inhibitors increase the chance of a heart attack in high risk groups, for example people who have already suffered a heart attack," explains primary...
More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
...s who received at least a 60-day supply of a COX-2 inhibitor
or other prescription NSAID between June 2000 and ...cluded. Of the 6,250 patients, 1,005 used a COX-2 inhibitor
and 5,245 used some other NSAID. The patients in the study were 70 percent female, 50 percent Afric...
Study estimates number of excess cases of coronary heart disease caused by Vioxx
...b) belongs to a class of cyclo-oxygenase 2 (COX-2) inhibitor
selective non-steroidal anti-inflammatory drugs (N...of Vioxx compared with other (NSAIDs) or the COX-2 inhibitor
celecoxib (Celebrex), a drug commonly used as an alternative to Vioxx. They analysed data from 1.4 ...
Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...isk patients in 2002. Over time, growth in COX-2 inhibitor
use was most likely to come from those users least likely to benefit from these drugs. By 2000, more patients were receiving COX-2 inhibitors than standard NSAIDs, including an estimated 16 million people suffering from congestive heart failure, or l...
Common antidepressants lower effects of tamoxifen in many women
...er study showing that selective serotonin reuptake inhibitor
antidepressants may hinder the effectiveness of tamoxifen, a drug commonly administered to breast cancer patients. The study also reports that researchers now have pinpointed genetic types that are linked with this effect. Led by David Flockhart, M....
Controversial drug shown to act on brain protein to cut alcohol use
...d GDNF activity. Finally, they showed that a known inhibitor
of GDNF blocked Ibogaine's ability to decrease alcohol craving in the rats, suggesting a direct link between Ibogaine's desirable actions and GDNF. "If we can alter the GDNF pathway, we may well have a new treatment against alcohol and drug addiction...
Editorial urges 'black-box' warning for Bextra and Celebrex
...howing that the combination of aspirin and a COX-2 inhibitor
could make plaque in the arteries more likely to rupture and cause clotting, resulting in heart attack or stroke. "These results have disturbing implications for patients at high cardiovascular risk treated with aspirin and a COX inhibitor," writes ...
Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
...alysis of two placebo-controlled trials, the COX-2 inhibitor
Bextra elevated the combined incidence of heart at...rial alone. Their analysis suggests that the COX-2 inhibitor
Bextra elevated the combined incidence of heart attack and stroke three-fold in the study population...
Heart patients treated by non-cardiologists less likely to receive medications
...d from the hospital with a prescription for an ACE inhibitor
and other recommended medications if they are trea...ted for several key medications, including: ACE inhibitor
(prescribed for 61 percent of patients upon discharge by cardiologists versus 35 percent by non-card...
Entrepreneurism Center at UC San Diego funds commercialization of lung, shock, other devices
...ll filter the plasma in the presence of a protease inhibitor
to block complement and thrombotic cascade activat...ation with the modified glass filter with protease inhibitor
serves to reduce the level of inflammatory mediators in a rodent model of shock, improve blood press...
Women need less morphine after hysterectomies with new treatment
... called gabapentin and an anti-inflammatory COX-2 inhibitor
drug called rofecoxib, in addition to self-administered morphine. The patients were asked to rate their pain while at rest (lying in bed), sitting up and coughing. There was also one measure of lung function, which assessed air flow after patients to...
Timing appears essential to combining antiangiogenesis and radiation therapy
...eated with various combinations of an angiogenesis inhibitor
called DC101 and radiation therapy. DC101 alone produced a minor delay in tumor growth, and radiation alone produced a more significant growth delay. But of five different schedules of combined treatment, only giving radiation from 4 to 6 days aft...
Scientists identify protein critical to melanoma growth
...ls. Unlike conventional chemotherapy drugs, a CDK2 inhibitor
drug wouldn't be aimed at killing melanoma cells, ...ttle toxicity to a person who would receive a CDK2 inhibitor
to treat melanoma," says Fisher, who is also an associate professor of pediatrics at Harvard Medical...
1 2 3 4 5 6 7 8 9 10