Reviparin effective in reducing risk of death after heart attack
...-blockers, and angiotensin-converting enzyme (ACE) inhibitors reduce the risk of death when used early in patients after a heart attack, the rate of death and illness remains high. No antithrombotic or newer antiplatelet drug has been shown to reduce the risk of death after a heart attack. Salim Yusuf, D.Phil....More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
...rial (CRESCENT) evaluated the effects of the COX-2 inhibitors and naproxen on 24-hour blood pressure readings in...S (non-steroidal anti-inflammatory drugs) or COX-2 inhibitors are chosen for osteoarthritis management for patients with hypertension and type 2 diabetes and furt...Study estimates number of excess cases of coronary heart disease caused by Vioxx
... focus on the cardiovascular safety of other COX-2 inhibitors (coxibs). Professor Webb concludes: "It now falls to the manufacturers, under the careful review of the regulatory authorities, to provide the evidence that this class of drugs is safe, if necessary including studies that directly address cardiovasc...Vioxx went mostly to patients who didn't need it, Stanford researcher says
.... Stafford said the problems associated with COX-2 inhibitors should serve as a cautionary tale about the growin...o the risk of heart problems, Stafford said. COX-2 inhibitors have been at the center of a controversy since last September when Vioxx was pulled from the market ...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...d that the heavily advertised drugs known as COX-2 inhibitors were being over-used, often by patients unlikely t...nflammatory disorders such as arthritis. The COX-2 inhibitors are no more effective in relieving pain than aspirin, ibuprofen, or any of the traditional non-stero...Editorial urges 'black-box' warning for Bextra and Celebrex
...on, which issued a Public Health Advisory on COX-2 inhibitors and other non-steroidal anti-inflammatory drug pro...erg said. FitzGerald, who has been studying COX-2 inhibitors for more than six years, says that plans by Pfizer to study potential cardiovascular benefits of Cel...Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
... Penn, raised the possibility that selective COX-2 inhibitors might predispose patients otherwise at risk for an...echanism proposed by FitzGerald in 1999 that COX-2 inhibitors may be problematic for those at risk for heart disease. COX-2 is the main source of a fat prostacyc...Georgia Medicaid program saves $20 million by controlling use of anti-ulcer drugs
...ions for anti-ulcer medications called proton pump inhibitors (PPIs). The savings were reported in a study published today in the American Journal of Managed Care by researchers at Express Scripts, the pharmacy benefit manager serving the Georgia Medicaid program. In 2001, Georgia Medicaid faced a potential bu...New theory chalenges current view of how brain stores long-term memory
... results into question. For example, synthesis inhibitors that block the production of new proteins by more ...emory impairments. Additionally, protein synthesis inhibitors cause a number of side effects that could lead to memory loss caused by something other than protein...Is it all in the mind or is it a medical condition?
...with treatment by medical therapies, such as PDE-5 inhibitors and anti-depressants. New therapies, including those that raise serotonin, are currently being developed to treat "rapid" ejaculation."...Entrepreneurism Center at UC San Diego funds commercialization of lung, shock, other devices
...inflammatory mediators in the presence of protease inhibitors under in-vitro conditions, and whether filtration with the modified glass filter with protease inhibitor serves to reduce the level of inflammatory mediators in a rodent model of shock, improve blood pressure and survival. John West, Professor "Ha...Jefferson scientists find zinc may help prevent esophageal, oral cancers
...n. They found that the rats treated with the COX-2 inhibitors had a reduction in both COX-2 and cellular proliferation in the esophagus. "Zinc treatment restores many systems affected by the lack of zinc," Dr. Fong notes. "Zinc deficiency upregulates COX-2. Zinc replenishment restores it to near normal levels."...Poor response to chemotherapy does not mean poor outcome for patients with rare breast cancer
...roup). Use of hormonal therapies such as aromatase inhibitors "may represent an interesting approach to treating invasive lobular carcinoma," and that use of systemic chemotherapy might be limited to women with inoperable invasive lobular carcinoma tumors, he says. "In the end, our study indicates that primary ...OHSU researcher says FDA could broaden access to results of clinical drug trials
...ding the safety and efficacy of serotonin reuptake inhibitors given to pediatric patients with depression. The two most frequently suggested remedies for the selective reporting of clinical trials results have been to register all clinical trials and to make their results publicly available. "Registries have be...Timing appears essential to combining antiangiogenesis and radiation therapy
... be crucial to successfully combining angiogenesis inhibitors with radiation treatment and reveal more about exactly how these drugs work to fight cancer, which is somewhat different from earlier theories. "The blood vessels that develop to supply nutrients to a tumor are not normal," says Rakesh Jain, PhD, dir...Scientists identify protein critical to melanoma growth
...but the finding revives the strategy of using CDK2 inhibitors as a potential treatment even if only for this one form of cancer. And, since it's been previously shown that normal cells can divide and grow normally without CDK2 (other types of CDK molecules apparently can take over the job) "this is good news, ...... systematic review of selective serotonin-reuptake inhibitors in childhood depression published in the April 2004 issue. Lancet Editor Richard Horton comments: "This study commanded strong support among the journal's editors. It was not only the paper of the year. It was part of the story of the year as well-a...How platelets help cancer invade other tissues
...rmal platelet function. Platelet-specific integrin inhibitors like Integrilin fall into this category. The study also suggests that drug-mediated inhibition of platelet-derived LPA and LPA receptors present on tumor cells may be another promising target for reducing or preventing bone metastasis....Certain high blood pressure combination therapies elevate risk for death from cardiovascular disease
...beta-blockers, angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers. While previous rese...ronary heart disease or stroke, diuretics plus ACE inhibitors or calcium channel blockers did not differ from diuretics plus beta-blockers. Monotherapy with calc...Aromatase inhibitors should be first-line treatment for certain type of breast cancer
...mments: "Results from studies evaluating aromatase inhibitors after 23 years or 5 years of adjuvant tamoxifen, compared with continuing tamoxifen, suggest that it is reasonable to switch patients currently on tamoxifen to an aromatase inhibitor. However, these new data from the ATAC trial suggest that it is no...