Tag: "inhibitors" at medical news
Jefferson neuroscientists studying new type of Alzheimer's drug to halt disease progression
...dministration-approved drugs called cholinesterase inhibitors
don't work on the amyloid protein, Dr. Rovner explains. They block enzymes that degrade acetylcholine, a neurotransmitter important for memory in the central nervous system. They treat the symptoms, not the underlying disease. Four drugs Aricept, Ex...
Scientists discover enzyme crucial to HIV replication
...cade, two classes of HIV inhibitor drugs, protease inhibitors
and reverse transcriptase inhibitors, have greatly...hat occurs with protease and reverse transcriptase inhibitors
might thus be eliminated with a successful DDX3 inhibitor....
Enzyme linked to mania and schizophrenia impairs higher brain functions
...rly susceptible to stress-induced dysfunction. PKC inhibitors
may be useful in treating these illnesses, according to Amy Arnsten, associate professor, Department of Neurobiology at Yale School of Medicine and senior author of the study. "These new findings may also help us understand the impulsivity and distra...
Use of stomach acid-suppressive medications associated with increased risk of pneumonia
...ses of acid-suppressive drugs (such as proton pump inhibitors
or H2-receptor antagonist drugs). "The effectiveness of acid-suppressive drugs in the treatment of upper gastrointestinal tract symptoms is excellent. Acid-suppressive drugs nevertheless seem to have some significant drawbacks," write the authors....
Advances in understanding brain circuits responsible for tics in Tourette's shed light on disorder
...h Tourette's and that selective serotonin reuptake inhibitors
reduce the symptoms of obsession and compulsions, Roger Albin, MD, and colleagues at the University of Michigan department of neurology investigated the idea that the ventral striatum--a brain region where both dopamine and serotonin have important f...
Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response
... We plan to exploit these findings by adding COX-2 inhibitors
like Celebrex (celecoxib) to our clinical trials f...ack said. "These findings support the use of COX-2 inhibitors
as a means of promoting Th1-directed tumor antigen presentation in clinical trials of dendritic cell...
p110 delta: A key player in the allergic response
...k points towards a promising future for developing inhibitors
for allergic conditions, but we are still a long way from developing a drug for human patients." The LICR group's research efforts are also focused on their findings that p110delta could also play a role in certain tumours, like leukemia, and that ta...
Two novel agents work synergistically to treat lung cancer in animal experiment
...ects of systemic IGF, says Lee. Not only do these inhibitors
stop growth signals from reaching the cell, "these binding proteins also have the independent ability to enter cells and shut down the growth cycle and induce the cell to self destruct," says Lee. While previous work at M. D. Anderson has shown...
Scientists find new clues underlying mood disorders
...had been treated with selective serotonin reuptake inhibitors
(SSRIs), a common medication for depression, showed smaller changes in the fibroblast growth factor system than those who had not been treated. "The fact that fibroblast growth factors were not as altered in individuals treated with SSRIs sugg...
New way of controlling cholesterol may help treat Alzheimer's
...erol storage in brain cells of mice. Because ACAT inhibitors
are metabolized quickly, the researchers used impl...opriate for human trials, Kovacs notes, other ACAT inhibitors
are in the process of clinical testing in humans for cardiovascular disease. Her group is now study...
Blood pressure drugs may slow deterioration of Alzheimer's
...gs are used to treat high blood pressure. Only ACE inhibitors
that can penetrate the blood-brain barrier were sh...skills of those who took the brain-penetrating ACE inhibitors
declined only slightly over the year. The skills of those who took the other drugs declined signific...
Mechanism found that 'protects' aggressive melanoma from angiogenesis inhibitors
...echanism that may help to explain how angiogenesis inhibitors
work on normal, blood vessel-forming endothelial c... In the past decade, many new angiogenesis inhibitors
have been identified, and several have been shown effective against tumor growth in laboratory exper...
Stanford scientists help bring study of smallpox virus into 'molecular age'
...t Ebola, indicating that smallpox may be producing inhibitors
of these molecules. Of particular interest in future studies, said Relman, is to identify the events that happen soon after infection - the "early molecular signatures" associated with the virus. Such markers could be useful in guiding interven...
FDA approves EPZICOM
...s two widely-used nucleoside reverse transcriptase inhibitors
(NRTIs), EPIVIR(R) (lamivudine, 3TC) and ZIAGEN(R)...o known pharmacokinetic interactions with protease inhibitors
(PIs) or nonnucleoside reverse transcriptase inhibitors
(NNRTIs). EPZICOM can be combined with PIs ...
Different subgroups of alcoholics respond differently to serotonin-acting medication
...erotonin functioning. Selective serotonin reuptake inhibitors
(SSRIs) help to maintain optimal levels of serotonin. New findings indicate that Type A alcoholics respond better to an SSRI called sertraline (Zoloft) than do Type B alcoholics, both during treatment and for six months following treatment. Alcoho...
Study finds Velcade major improvement over standard therapy for relapsed multiple myeloma patients
...first of a class of substances known as proteasome inhibitors
to reach the clinical trial stage. Preclinical studies by researchers at Dana-Farber demonstrated that the drug which acts on intracellular structures called proteasomes, which control the degradation of key proteins controlling myeloma cells prev...
Adrenaline packs a powerful punch in the use of antidepressants
... used to treat depression: norepinephrine reuptake inhibitors
(which work by increasing the synaptic activty of ...ne in the brain); and selective serotonin reuptake inhibitors
(which elicit their effects by increasing the activity of serotnin in the brain). Previously, it wa...
COX-2 inhibitor could be safest anti-inflammatory drug for older people
... between non-selective NSAIDs and individual COX-2 inhibitors
with respect to risk of admission for congestive heart failure. The clinical relevance of these findings, in view of the widespread use of the drugs, warrants the implementation of large-scale randomised controlled trials to examine this issue furthe...
May/June 2004 Annals of Family Medicine tip sheet
...s. As popular prescription drugs like proton pump inhibitors
and statins head toward the OTC marketplace, they add, better patient education and post-marketing surveillance are essential to assure proper usage of over-the-counter medications. Consumer Knowledge of Over-the-Counter Phenazopyridine Chih-Wen S...
Researchers discover that a protein in grape skins can kill cancer cells
...a process called apoptosis. The use of NF-kB inhibitors
like resveratrol also has important implications for increasing the effectiveness of cancer therapy. "Researchers are always looking for ways to improve cancer therapy," Mayo said. "Current studies are using compounds similar to TNFa in conjunction w...
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