Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...tors, receive the hormone's signal and transmit it inside the cell.The signal initiates a chain of events th... fat cell surface.This binding transmits a message inside the cell, telling it to burn calories and releaseheat energy. As the process continues, energy burne...Partial Liquid Breathing Improves Lung Function, Chances of Survival in Sick Preemies
...- increasing the pressure and oxygen concentration inside the lung in an effort to force more oxygen into the blood stream -- can cause permanent lung damage and result in a chronic disease called bronchopulmonary dysplasia. Partial liquid ventilation involves introducing an oxygen-rich liquid called perflu...Scientists Produce New Anti-Malarial Compound
...roxide. The researchers found that iron from blood inside the malariaparasite provides a source of electrons that rupture the bondbetween the two adjacent oxygen atoms in the peroxide structure.The result is an oxygen free radical -- an atom with an unpairedelectron. The free radical attracts a hydrogen ato...Fertilization Protein Structure To AID in Leukemia Treatment
...r. The secondary messenger is synthesized inside the egg from the building blocks of DNA. The synt...roviding a means for it to transmit signals to the inside of white blood cells. "By modifying the chemical bonds in molecules outside the cell, the size and...Ultrasound Helps Pediatric Heart Surgeons After Open Heart Surgery
... just a single window, not enough to see the whole inside of the house, butwith two or three other windows, you get a better picture." Rodriguez received the Popham Clinical Research Fellowship Award fromChildren's Hospital of Eastern Ontario in 1996 to continue his clinicalinvestigations of brain f...New Test May Improve Treatment Of Kidney Disease
...not necessarily predict how the drugs will respond inside the body. Patients who wish tovolunteer for the studies can call (410) 955-5268....Affordable, Hand-Held Biosensor For Diagnostics
... standard desktop.ediscovery of some "new physics" inside the porous silicon film. Though not fullyunderstood, the scientists speculate that the binding of molecules to thesurface significantly alters the refractive index of the silicon matrix itself,resulting in a major increase in sensitivity. "It...Added Benefit Found For Aspirin Use In Patients With Vessel Disease
...ult can be damage to the endothelium that linesthe inside of the vessel. When there is damage to the lining -- known asendothelial dysfunction -- the vessel may not contract properly, leading toother potential problems. In this study, researchers found that when aspirin was given to 14patients with ...Snipping Inflammation In The Bud; New Agents May Provide Relief
...ounter drugs such as ibuprofen, is to block events inside the cell.The synthetic molecules in Kiessling's approach act as inhibitors on the outsideof the cell, attaching themselves to aL-selectin proteins and preventing the cell from linking with an opposing cell. But synthetic molecules that only inhibit c...Radio Frequencies Used To Kill Inoperable Liver Tumors At Penn's Cancer Center
...emed "inoperable" due to their anatomical position inside the organ itself. "Many patients exhibit tumors i...ectly into the center of the cancerous tumor. Once inside the tumor, the tip of the probe is carefully opened to permit heat-delivering wire extensions to pen...Successful Cancer Therapy May Doom Later Treatments To Failure
...and five mousecancers were grown at various places inside the mouse's body to represent whathappens during m...res, they will face an uphill battle once they get inside a tumor. The pressure exerted by the material surrounding tumor cells, called the interstitium, is e...Studies Look At Threshold Effect Of Cholesterol-Lowering "Statin" Drugs
...cholesterol because it helps form the obstructions inside the blood vessels, setting the stage for a heart attack or stroke. Sacks and his colleagues report data from the Cholesterol and Recurrent Events (CARE) trial, in which 4,159 individuals with coronary heart disease and blood levels of cholesterol ave...Widely Used Therapy May Not Be Effective In Treatment Of Acute Stroke
...e in whichfatty materials (plaque) build up on the inside of the walls of large arteries,such as the large carotid arteries in the neck that carry the majority of bloodto the brain. As part of the trial, the investigators established a guidelineto classify different subtypes of ischemic stroke, such as str...Drug's Effect On Chromosomes May Explain Second Cancers
...ese results help us understand where the drug acts inside thecell, and they may help us understand why it causes secondary cancers insome patients.” The study, co-authored by Muller, was published in a recent issue ofthe journal Biochimica et Biophysica Acta . Etoposide is a member of a small class ...Brain Tumor Treatment In Multicenter Tests
...and is released into the brain. Butthe drug that's inside the 'bar of soap' is protected; the water can't get inand deactivate it." The polymer package for the chemotherapy wafer was initially developed inthe 1980s at M.I.T. by Dr. Robert Longer. Animal and human studies led by JohnsHopkins University...Pioneer In Nuclear Medicine Wins Lifetime Award
...brain. Their pinpointing of the dopamine receptors inside the brain led to muchwork in addiction and drug design. The next year, they located the opiatereceptors. "We now know that cocaine affects the dopamine receptors," saidWagner, "and we continue to learn about addiction." Parallel to his work i...Drug Prevents Hearing Loss Caused By Brain Tumor Therapy
...ule drugs such as carboplatin fromreaching a tumor inside the brain. Using a sugar solution to temporarily shrink the barrier cells, therebycreating spaces between them, Neuwelt and his colleagues literally "opened thegate" for drugs such as carboplatin to enter the brain. They subsequentl...Repairing Cranio-Facial Deformities From The Inside Out
... patients adistraction device implanted completely inside the mouth that helps to regrowdestroyed bone, essentially growing a new jaw for the patient. Dr. Brian Smith, chairman of Oral and Maxillofacial Surgery at TempleUniversity Hospital and School of Dentistry, will implant the first internaloral...Novel Therapy To Treat Lung Cancer Patients Enrolling Patients At UCSF Cancer Center
... as extracellular matrix, that holds cellstogether inside tissues. This activity occurs in diseases in which healthytissue is broken down or unhealthy tissue grows, as in cancer and rheumatoidarthritis, Jablons said. Cancer tumors grow and spread, interfering with the functions of healthy tissue.Some MMPs......dwhite blood cells, posing no threat. "If you look inside the blood vessels of ahealthy person,you'll see th...In the lab, I can simulatethe conditions thatoccur inside the blood vessels, inside the body. In the past, biologists mainlylooked at how cellsinteract under...