DNA Imaging to Design Better Drugs
...ng agents," said Chaires, who has studied DNA-drug interaction fornearly 20 years. "Since some of the most effective agents in use incancer chemotherapy are DNA intercalators, this fundamental researchcould have important practical use." Bottomley and Williams believe their approach offers many advantagesover t...Discovery Hints At Multitude Of New Targets For Drugs
...roid receptor, also shows similarmulitple modes of interaction with drugs or hormones. "The discovery of such complexity in one receptor type is a phenomenon;the discovery of two is a paradigm," said McDonnell. "It's likelythat these findings will extend to other receptors, such as the male androgenrec...Fertilization Protein Structure To AID in Leukemia Treatment
...nia, is providing insights into the details of the interaction between sperm and egg. Remarkably, the same structure may hold a key to new treatments for leukemia, a kind of cancer that attacks the blood. The research, supported by the National Science Foundation, has revealed a previously unknown relat...Premature Birth Sometimes Can Adversely Affect Infant's Ties To Mother
...l infants. The researchers observed infant-mother interaction in homes and in a laboratory.All of the infants had spent an average of three months in intensive careat the University of Michigan Hospital and had survived without seriousphysical or neurological complications. Most troubling, Mangelsdorf said, wa...Bi-Monthly Boosts Of Aspirin Benefit Heart
... andclot-formation. "This red blood cell-platelet interaction may explain why manyindividuals respond to aspirin in a less than optimal fashion," says Marcus. But in their study, researchers found that a single 300-mg dose ofaspirin could initially "neutralize" the platelet stimulatory activity ...Crystal Structure Of gp120 Reveals HIV In Action
...signer'sdream. The deep cavity at the heart of the interaction is just begging to befilled with a high-affinity inhibitor," says Dr. Kwong. But the gp120 structure published now provides only one scene from amolecular dance that might, in the body, take several forms. So the researchersare fashioning ot...National Science Foundation Awards Knowledge And Distributed Intelligence Grants
...n-Austin, TX This project models the movement and interaction of fluids in surface waters and subsurface groundw...n; surface water circulation and pollution and the interaction between surface and groundwater environments. These applications have potential significant environ...WFU And IntraVec To Develop Innovative Cancer And HIV Treatments
...Ordinarily, the HIV binds to the host cell through interaction withchemokine (protein) coreceptor on the surface of the cell. But some people withcertain "defective" genes do not produce the chemokine that permits "docking" bythe HIV. Chen and his colleagues designed a novel approach called intracellula...AAPS Sponsors Second Frontier Symposium
...IDDK, NIH). The goals of this event are to foster interaction among scientists withinterests in structure, physiology, genetics/genomics, and pharmaceuticalaspects of membrane transporters, and determine the role of transporters in drugdiscovery, development and therapy. For more information on this event, incl...An Ergonomically Redesigned Analgesia Delivery Device Proves Safer And More Efficient
...DX 33 MHZ PC in a Windows 3.1 environment. Subject interaction with the interfaces was electronically recorded by...orkload came from an interface x task x repetition interaction (F(2,20)=8.62, p=0.002). The resulting effect of this interaction was a significant decrease in the ...UI Study Finds Social Support May Increase Longevity Of People With Schizophrenia
...patients with schizophrenia who hadfrequent social interaction lived on average 25 percent longer than patients whohad little or no social interaction. "The findings are consistent with other studies that show social factors arerelated to physical health and mortality in individuals with medical conditionssuch ......ever, favor the use of chat rooms, whichoffer more interaction and the development of relationships (49% females to 23%males) to visual erotica (50% males to 23% females). Most individuals reportedthat they go on line for sexual pursuits from home (78.8%); 5.8 percent admittedusing an office computer; and 12.7...USC Historian Sifts World's Oldest Printed Medical Books For Clues To Riddle Of Gender
...5),exploring the remarkable documentation of human interaction preserved in print-- theories and practice recorded in hundreds of case histories, recordingencounters between specific patients and their doctors. While recording the rise in status of learned physicians and their efforts todifferentiate themselves ...Multitasking Behaviors Mapped To The Prefrontal Cortex
...activated only during those tasks that involved an interaction between workingmemory and attentional focus decisions. The FPPC is the region of the brain that controls complex problem solving and isespecially well developed in humans as compared to other primates. The studyshowed that the FPPC selectively media...British Adolescents Need Government Support To Help Clean Up Their Act
...n unit to tackle the complexities derived from the interaction between poverty, low educational achievement and health. He concludes that the unit offers real hope for addressing teenage behaviour and encourages other health professionals to welcome the initiative....New Findings On Dopamine Receptor Biology: Implications For Mental Illness
...n andcognition. Deth's group found that dopamine's interaction with the D-4 receptorcan cause local increases in the fluidity of nerve membranes which can influencesynapse activity critical for normal cognition and attention. While researchers have long suspected that dopamine and folate contribute tomental illn...Aging alone does not affect brain system related to memory loss
...mentia. "This is something new for us -- to see an interaction between the aging processand a compromised brain," Sarter said. "We believe that people who developAlzheimer's disease have something wrong with their brain long before thesymptoms appear. It is the aging process that then makes the disease appear." ...Bioterrorism topic of first new nationally broadcast public health grand rounds session
...alth Grand Rounds provide an opportunity for close interaction onvery important health topics between the key components of the public health system; state andlocal health departments, schools of public health and the Centers for Disease Control andPrevention," Koplan said. "The CDC is pleased to partner with th...Computer matches CT scans to disease database
...onds. "This works through the synergy of human interaction and machine learningand computer vision algorithms," says Brodley, an assistant professor in thePurdue School of Electrical and Computer Engineering. Sophisticated software enables the user to carry out a visual sort ofkeyword search, a method re...Scientists capture images of brain in action as it's learning
...vity changes in the prefrontal cortexand increased interaction with sensory areas -- indicating a network of brainactivation. As they learned, these students started to perform the task faster.In the unaware group, there was no change in blood flow activity in theprefrontal cortex or indication of a larger syste...