Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...ith. Separating the effect of protein-ligand interactions from changes inprotein-water and ligand-water interactions remains "one of the mostdaunting barriers to predicting how ligands bind to their protein receptors,...New Approach To Multidrug Resistance
... use of chemotherapeuticagents would minimize drug interactions as well as side effects. The researchers are now doing animal studies to determine the most effectivecombination of drugs, and human clinical trials to determine the effectivenessof this approach in various natural cancers. The Dartmouth team includ...Common Drug-Capsule Coating Not As Inert As Previously Thought
...archers discovered that PEG can undergo attractive interactions withthe proteins that will result in the latter binding to the polymer surface. "Not only did the polymer switch from a protein-resistant stateto a protein-attractive state, we found the presence of the protein appearedto induce a change in the poly...Some Good News In Treating Infection Common To HIV Patients
...ultiple medications, which avoids toxicity of drug interactions and it's much less costly." The most common alternate method of preventing pneumocystis carinii is called aerosolized pentamidine. Kazanjian says this regimen is much more expensive than treatment with Bactrim and requires the HIV patient to come in...Physicians' Opinions Influenced By Drug Industry
...ore likely than critical authors to have financial interactions withmanufacturers of competing products (87 percen... the criticalauthors, were found to have financial interactions with at least onepharmaceutical manufacturer. Each of these results were statisticallysignificant. ...Targon And Duke Cancer Center Sign $3.75 Million Agreement To Produce Advanced Anti-Cancer Drugs
...review of new technologies will lead to additional interactions between Duke and Targon and to rapid development of commercially viable products for the oncology community. "This remarkable agreement promises to significantly accelerate theprogress of new cancer treatments from laboratory to clinic," said...Tighter Chemical Binding = Better Meds
...n model liquid water bytreating mathematically the interactions between thousands of individualwater molecules, thus computing the density of water at any temperature orpressure. "When we began our work 20 years ago, computer simulations hadonly been carried out for some simple liquids. With the development oft......er to understand and more precisely target the key interactions betweencamptothecin-Topo I/DNA. BioNumerik used this information to guide andcomplement the discovery and optimization of novel compounds for laboratorysynthesis and preclinical testing. In a presentation titled "BNP7787: Administration In Vivo Re...Clinical Pharmacists Improve Outcomes Of Heart Failure Patients
...tis essential that we know about all the different interactions between them,"she said. "As a clinical pharmacist... each other," O'Connor said. "The types of interactions are very complex," he continued. "Heartfailure patients are commonly on six to seven different medi...DFG To Fund Four New Research Units
...ter implants in the research unit "Studies of, and interactions at, biologised bone-implant interfaces". They will...ers will try to gain a better understanding of the interactions of animate and inanimate matter and expect to come up with fundamental findings to be used in design...Penn State Chemist Identifies New Lime Aroma Component
...thestudies on lime oils, including examining aroma interactions that may lead tomaking synthetic lime oil in the laboratory. She thinks there's a lot more sheand her students can "sniff out" about limes. Editors: Dr. Chisholm is at (814) 898-6412 or at mac8@psu.edu by email....Study Confirms Safety Of Common Heart Drug
...ter knowledgeof the drug in general, including its interactions with other drugs. That's whywe don't see as much toxicity anymore," Patterson says. "In our prospectivestudy at five hospitals here in North Carolina, the overall incidence oftoxicity was 4.1 percent, which is consistent with a recent retrospective r...Promising Bone Cancer Therapy Advances To Next Level
...the tin reach the bone withoutbeing sidetracked by interactions with the blood or being taken up into softtissue. After initial tests, the researchers assessed the therapy in animalsand then in human patients in the initial clinical trial. In the initial clinical trial, the Brookhaven researchers found t...UI Study Finds Social Support May Increase Longevity Of People With Schizophrenia
...tients," Christensen said. "The frequency of daily interactions withsupport providers or confidants seemed to make...y observed among patients with morefrequent social interactions might be due to the fact that social connectionscan help a person reduce negative health behaviors s...Tiny Tools Give New Meaning To 'Cutting Edge'
...ltrasonic needle will create similar needle-tissue interactions that reducepain. The immediate applications could be for people for whom needle usage is a factof life, such as diabetics who monitor their blood glucose daily. It could alsorelieve some of the severe discomfort caused by needles in cancer biopsies. ...Chronically Ill Teens Turn To Internet For Peer Support, Researchers Report
...s used universally. More than half of all interactions occurred at the message board, whereteens conversed with one another about living with CF and other, more commonteen issues. Researchers found a significant increase in the perceptions of thegroup when asked if they had friends with CF they could rel...Study examines faith healing in a cell phone age
...hbegun in the past study. Csordas has examined the interactions among three principal forms of contemporary Navajo religious healing -- traditionalNavajo ceremonies or chants, the ritual use of peyote by Native American Church (NAC), and the Pentecostal faith healing. Collaborating with Navajo and Anglo researche...Effects of nicotine influenced by housing and gender
...a lifetime oflearning, social environments, family interactions and many other factors," saysFaraday. "If you can demonstrate that a drug or environment produces an effectin a rat that humans also report, then it is likely that the human experience isat least in part biologically based and 'hard-wired' rather tha...UK researchers examine personality and social behavior changes in patients following stroke
...'sspouse also participated in the discussion. All interactions were videotaped. Two graduate student observers watched portions of the videotapes andmade judgments about the personality and social competency of the patients. Both sets of stroke patients were perceived more negatively -- lessoutgo...Friends don't influence the prejudices and stereotypes of adolescents
...udice and stereotyping may be rare in adolescents' interactions with their friends, which would produce limited influence. Secondly, adolescents may influence each others' behaviors, but not their attitudes; there is often a discrepancy between attitudes and behavior." The final possible explanation for no effe...