Antabuse May Inhibit Fatal Reaction To Anesthetic
...ly inhibit P450 2E1from carrying out this unwanted intracellular mission by giving patients a drugcalled disulfiram before anesthesia. "We manipulate the activity of the enzyme with disulfiram, known by thetrade name Antabuse. We found that a single dose could 'turn off' P450 2E1,"Kharasch said. Th......A). By identifying and understandingthe intricate, intracellular mechanisms by which SCA2 functions, researchershope to eventually find treatments and cures not only for SCA2 but for theseother neurogenerative diseases as well. Wednesday, April 21, 10:15 a.m. "Mapping of a New Autosomal DominantSpinocerebellar Ata...Mini-motor models nature, advances miniaturization technology
...or processes that range from musclecontraction and intracellular transport to oviduct functioning and spermswimming. The prototype molecular motor was designed and constructed by Dr. T. Ross Kellyand coworkers at Boston College. A report describing the motor appears in theSeptember 9 issue of Nature. "This is s...AAPS announces 1999 award winners
...hnologies. Dr. Hughes' researchhas focused on the intracellular fate of macromolecules to enhance therapeuticapproaches for the treatment of Alzheimer's Disease, tuberculosis andhypertension. He is associate professor in the Department of Pharmaceutics atthe University of Florida. This grant is sponsored by Pfi...Brain scans of Gulf War veterans show brain damage
...es brain chemistry by using radio waves to measure intracellular concentrations of protons and estimate the concentrations of common brain chemicals. Previous magnetic resonance imaging (MRI) on the veterans found no visible structural changes to the brain. But by using MR spectroscopy, researchers could look at...Sustained use of anti-depressants increases cell growth and protects cells in the brain
...ns of anti-depressants, looking at the role of the intracellular signal transduction pathways that control neuronal function. They have identified several actions of anti-depressants which indicate that anti-depressants influence the survival or the number of neurons in the hippocampus. This study was intended to ...Mouse provides clues about chronic pain
...t NMDA receptors can be activated, and a series of intracellular signaling molecules can be triggered. This cascade of events leads to long-lasting changes in the way neurons communicate and can lead to changes in how the human or the animal perceives external pain signals. The genetically altered mouse that ove...New definition may make number of heart attack cases soar
...t muscle dies and in the process, the muscle leaks intracellular components such as CKMB and troponin into the surrounding tissues," says Mark Meier, M.D., UMHS resident physician and a study researcher. Cardiac troponin is a more sensitive marker of myocardial damage because the troponins are more abundant in t...HIV protein stops cell division, leading to more virus and sicker patients
...ne of the bodys best defenses against the invading intracellular foes like viruses and some bacteria. But when they...herman said. The technique utilized here is called intracellular p24 staining and churns out results in a matter of days, using the patients own blood cells. This gi...Post-genomic technique provides real-time, multiscale look at protein life cycles in living cells
...follow the dynamics of assembly and disassembly of intracellular structures containing the tagged protein. The experiments presented in the Science article followed the trafficking and turnover of connexins, the protein constituent of gap junctions, which are tissue membranes formed by the association of thousands...Tau protein required for development of Alzheimer's disease
...hat stabilize the cells shape and act as a sort of intracellular molecular transport system. These results suggest that neurons that are able to maintain the composition of microtubules with rapid turnover as they age that is, tau-depleted neurons might be resistant to neurodegeneration, Ferreira said. "These...UCSD faculty elected to membership in prestigious professional organizations
...he Institute of Medicine, he has helped define the intracellular pathways for insulin and growth factor action, and helped develop insulin-sensitizing drugs that are now standard therapies for Type II diabetes....Blocking gene may reduce lung scarring caused by radiation therapy
...ck-out mice" engineered to lack the gene, known as intracellular adhesion molecule (ICAM1). "If you eliminate ICAM1, you eliminate the inflammatory response," Hallahan said. So the next question to be addressed was whether the initial inflammation was the cause of the subsequent fibrosis and whether preventing the...Researchers shed light on mechanisms of voluntary alcohol consumption
...rotein kinase A (PKA), another protein involved in intracellular communication, gene expression, and animal behavioral responses to alcohol. Although acting through a different receptor (adenosine type 2, or A2), ethanol generates the same signaling protein and subsequent activation of PKA. Further, dopamine and e...Study finds new target for development of anti-cancer drugs
...iscommunication causes traffic jams to occur among intracellular signaling proteins. Such a high frequency of km23 alterations in human tumors suggests that the alterations are important for tumor development and growth. Finding drugs to override these defects should prevent the tumor from growing and spreading fu...Capturing airborne pathogens, breath tests for lung cancer
...y cellular processes within single living cells or intracellular organelles and aid research in molecular and cellular biology. ULTRAFAST LASER AUTOMATES BRAIN-TISSUE IMAGING Jeff Squier, Colorado School of Mines A new technique may help speed up progress in fundamental research on brain disorders such as Alzh......to the EGF receptor. Gleevec TM , which targets an intracellular protein which sends signals similar to the EGF receptor, has completely changed the way chronic myeloid leukemia (CML) is treated and it has also shown to work in rare gastrointestinal stromal tumors (GIST). Iressa was the third such targeted therapy...Environmental influences found to have role for development and function of the pain system
...rom control rats. Laird also has described how the intracellular signaling pathways and molecular mechanisms known to be critical for classical learning and retention of memories in the hippocampus seem to be involved in spinal "memories" of painful injury. The scientists have shown in both rats and mice that extr...Chagas' disease: virulence factor identified
...circulates and reproduces in the blood and another intracellular one without flagellum (amastigote), which in its turn multiplies to produce another batch of circulating forms. These two forms prove to be able to secrete this protein Tc52. The research team revealed it to have several activities, including enzyme ......protein called "tau." Normally, tau is crucial for intracellular functioning and structure, but in Alzheimer's patients, a stringy cluster of tau and phosphate molecules form, leading to dysfunction that impairs the cell's ability to communicate with neighboring cells. This eventually leads to cell death, contribu...