Effectiveness of safer smallpox vaccine demonstrated against monkeypox
...duced against two different forms of the poxvirus: intracellular mature virions (IMVs), virus particles thought to be responsible for transmitting the disease from one host to another; and extracellular enveloped virions, IMVs with an added outer membrane that play a large role in spreading the disease within the ...2004 Salivary Research Award to Ekstrom
...ed specialized studies on the receptors and on the intracellular mechanisms involved, including the synthesis of proteins as well as their secretion. Many of his investigations have involved studies on reflex activity in conscious experimental animals. His ideas usually emerge from in vivo studies on a variety of ...Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
...ted to the EGF receptor. Gleevec, which targets an intracellular protein which sends signals similar to the EGF receptor, has completely changed the way chronic myeloid leukemia (CML) is treated and it has also shown to work in rare gastrointestinal stromal tumors (GIST). Iressa was the third such targeted therapy...Study finds Velcade major improvement over standard therapy for relapsed multiple myeloma patients
...a-Farber demonstrated that the drug which acts on intracellular structures called proteasomes, which control the degradation of key proteins controlling myeloma cells prevented tumor cells from proliferating, and was active even against those that were resistant to other known therapies. Later experiments found ...New way of controlling cholesterol may help treat Alzheimer's
...olesterol is stored in the cellular membrane or in intracellular droplets, also appears to regulate the formation of amyloid-beta, the protein fragments that make up amyloid plaques. The current study was designed to test that same approach in living animals. At first, researchers tested whether the ACAT inhi...New protein associated with aggressiveness in breast and ovarian cancer
...are now being tested. Rab proteins are anchored to intracellular membranes, and are activated when a receptor on the outside of the membrane is stimulated and the signal is brought into the cell. The "best current evidence" is that Rab25 is involved in deciding whether those internalized cell surface receptors "wi...Molecular tailoring of chemotherapy with novel imaging techniques
...ultiple genes simultaneously as well as additional intracellular events in the process of cell death. In another study El-Deiry and colleagues combine imaging techniques and a mouse model for colon cancer. "In this research, we're combining two very powerful emerging technologies," says El-Deiry. "This is the fir...Two-fisted assault on dopamine transport system may be foundation of Parkinson's disease
... of the targets of the pesticide was microtubules intracellular highways for transporting various chemicals such as dopamine to the brain area that controls body movement. Normally the enzyme parkin would protect the neuron from rotenone's assault on microtubules, Feng said. "When micro...Transport system smuggles medicines into brain
...direct conjugation can be chosen, dependent on the intracellular destination of the medicine.......further studies of thyroid regulating hormones and intracellular iodide concentrations may "indicate areas of intervention for targeted preventive and therapeutic purposes."...