Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
... haveto analyze a complex combination of reactions involving not only the proteinsand ligands but also the water that those molecules interact with. Separating the effect of protein-ligand interactions from changes inprotein-water and ligand-water interactions remains "one of the mostdaunting barriers to...American Heart Association Comment: Lancet (Jan. 24, 1998) Report
...k of heart attack by 34 percent in a 13-year study involving 5,499 men. Valentin Fuster, M.D., Ph.D., president-elect of the American HeartAssociation, says the study's findings "open the door" to the exploration of newtreatments for preventing heart attack deaths in healthy individuals at highrisk. ......in cell damage after stroke. The clinical trial, involving nearly 400 patients in 33 centers nationwide,showed no statistically significant difference in five areas--including fullrecovery and mortality rates, neurological and cognitive function--betweenpatients with stroke who were given citicoline, and th...MIT Solution To Math Problem Could Lead To Better Dental Implants, More Resistance To Missiles
...ry is that it provides cleanmathematical solutions involving quantities which can be accurately measured byexperiments," Professor Suresh said. The work has since led to patents on a new machine for testing gradedmaterials and for the software that extracts information about the materials'properties. B...Four-Year Study Shows Long-Term Effectiveness Of Proscar In Treating Enlarged Prostates
...AS * Feb. 26, 1998 ** Results of a four-year study involving 3,040men have shown that those taking the drug finasteride (Proscar) forenlarged prostate glands reduced their risk of needing surgery orexperiencing acute urinary retention by more than half. Researchers from 95 medical centers reported thei...New Math, High-Tech Imaging Solving Old Riddle: How Does The Brain Operate When We Think?
...roke, cancerand cardiac disease,which are diseases involving changes in blood flow and oxygen use in differentorgans. fMRInow has the potential to become much more like a routine blood test that letsdoctors diagnosediseases by comparing levels of substances in the blood with normal ranges." The type of ...Tighter Chemical Binding = Better Meds
...of insulin for diabetics ina gene therapy approach involving implanted cells. Vast Increases in Computer Speed Vast increases in computer speed in recent years make it possibleto perform complex computations of chemical processes in minutes insteadof days, said Jorgensen, who has created a supercomputer in h......mputers toconstruct a detailed computational model involving human Topoisomerase I and DNAin order to understand and more precisely target the key interactions betweencamptothecin-Topo I/DNA. BioNumerik used this information to guide andcomplement the discovery and optimization of novel compounds for laborato...Area of Research Outlined For Promising New Cancer Drugs
...drugs' possibilities but cautionsthat more studies involving the basic science of these drugs are needed. Research now under way in Castellino's laboratories will attempt to address someof these issues. Castellino, whose laboratory is without question one of the top handfulstudying blood clotting mecha...Metrifonate, A New Alzheimer Drug, Helps Behavior Problems
...with those at the beginningof the study. One test, involving paper and pencil tasks, evaluated cognitiveperformance. Through interviews with subjects and caregivers, others evaluateddaily function and psychiatric and behavioral disturbances. Test scores of thepatients who took the inactive substance declined p...Efficacy And Safety Of Oral Phentolamine (Vasomax) For The Treatment Of MinimalErectile Dysfunction
...cebo-controlled,parallel group, double-blind study involving randomized doses of 40 mg or 80 mgof either oral phentolamine or placebo. In the 40 mg group, out of 152 men, 56(37%) responded and 96 (63%) did not. With the 80 mg dose, out of 159 men, 72(45%) responded and 87 (55%) did not. Out of 148 patients ...Intervention can help reduce risky sexual behavior, according to results published in Science
... report the results of a major HIVprevention trial involving one of the most at-risk groups: low-income women andmen living in urban areas. The results of this study, the largest of its kind,suggest that behavioral interventions can indeed reduce HIV-related sexual riskin this population, at least over a one-y...Promising Results For Woman-Controlled Anti-HIV Product
...led anti-HIVproducts, according to a related study involving women at high risk of HIVinfection through their own or their partners' drug use. BufferGel and othermicrobicides work by reducing the vaginal pH level, increasing the naturalacidity that provides a harsh environment fatal to many microorganisms,incl...Anti-Depressants: Miracle Drugs Or Placebos With A Buzz?
...l the studies in the meta-analysis, includingthose involving drugs not considered to be anti-depressants,but which were as effective as anti-depressants in treating depression. As the editors of Treatment & Prevention point out i...Parenting CD-ROM Helps Reduce Children's Behavioral Problems
ATHENS, Ohio -- Studies involving an interactive CD-ROM that offersinstruction on parenting skills suggest the three-hour program can help reducethe frequency and severity of children's behavioral problems, according to anOhio University psychologist who presented the findings at a r...Researchers Begin Drug Trial In Hope Of Finding New Ways To Treat Acute Kidney Failure
...people die each day while waiting. Star's research involving the drug alpha-MSH could reduce the disparity of organallocation in this country that results in unnecessary deaths. "We have foundthat alpha-MSH treatment significantly reduced renal damage and inhibited thedisease at a number of different steps eve......atment within the BHF guidelines. Their research, involving over 1000 (1046) patients, was undertaken in urban, suburban and rural areas in northeast Scotland. They found that the first contact that a patient had with a medically qualified person was most commonly with a general practitioner, who was able t...New Short-Acting Anesthetics Cut Recovery Time
..., Apfelbaum presented aUniversity of Chicago study involving five community hospitals or surgi-centerstrained to implement the newer forms of anesthesia, using short-acting,fast-emergence general anesthetics, which allow patients to regain consciousnessand alertness within minutes. His team found that 15 to 40...Clinical Trials Announced Using Non-Invasive Innovative MRI To Diagnose Breast Tumors
...ani's method. (This study followed up on the one involving 20 women, reported on by Prof. Degani last year in Nature Medicine.) "Conventional mammography and breast sonography sometimes result in ambiguous findings which could indicate cancer. Too often, we believe, women are told to come back in six month...