Single-donor islet transplantation procedure shows promise for patients with type 1 diabetes
Patients with type 1 diabetes who received islet transplantation from a single donor pancreas were ...nd information in the article. The success rate of islet (cells that produce insulin to control blood sugar levels) transplants has recently been increased m...World-first living donor islet cell transplant a success
...irst suggested the idea of starting a living donor islet transplant program in Kyoto while lecturing there ...r and kidney transplantation there. "Living donor islet transplants could allow many more desperate patients with type 1 diabetes to get successful islet tr...Biotech breakthrough in islet cell replacement for type 1 diabetes
...ion (JDRF) to advance technologies in the field of islet cell replacement for the treatment of type 1 diabe...ary initiative to enhance survival of transplanted islet cells in patients with type 1 diabetes, linking Northwestern University researchers in transplant su...Latest results from international islet transplant study confirm potential patient benefits
...center clinical trial of the Edmonton Protocol for islet transplantation. The results provide further confirmation that transplantation of pancreatic islet cells can safely and effectively eliminate the need for daily insulin injections in patients with ty...Disruption of a gene may prevent type 1 diabetes, UVa researchers find
... type 1 diabetes and possibly advance the field of islet replacement therapy to reverse established diabetes. This study also represents a key collaboration between investigators in the Diabetes and Hormone Center of Excellence at U.Va. and Dr. Marcia McDuffie in the department of microbiology," Nadler sai...New animal model for Alzheimer vaccine
...inated with a "control" amyloid: in this case, the islet amyloid that builds up in diabetes. They did not develop antibodies against beta-amyloid and had much lower circulating beta-amyloid levels. None of the four monkeys showed any evidence of brain inflammation. The National Institute of Neurological ...U of M researchers a step further in Type 1 diabetes treatment
...cipated in this trial. The combination of improved islet preparation techniques and optimized recipient imm...This success builds upon other recent successes in islet transplantation and marks a critical step in developing islet transplants into a vital treatment opt...University of Pittsburgh and French National Institute begin scientific collaboration
... cell populations to be studied include pancreatic islet cells, stromal cells those coming from connective tissue and endothelial cells, which make up the lining of blood vessels and other internal organs. Such investigations will form the bedrock of an initiative that goes beyond conventional collaborat...Gene therapy technique could aid islet transplants for diabetes, says Pittsburgh study
PITTSBURGH, Feb. 4 Treating pancreatic islet cells with a growth factor can dramatically reduce...munosuppression therapy currently used after human islet cell transplants is harmful to transplanted rat pancreatic islets and can actually induce diabetes i...Understanding the autoimmune response in type 1 diabetes
... research has suggested that T cells that react to islet beta cells can contribute to the autoimmune respon...nses to a panel of epitopes naturally expressed by islet cells and demonstrated that it is the pathways of T cell differentiation and maturation in reaction ...Drug prevents diabetes recurrence after islet cell transplantation
...betes from coming back after insulin-manufacturing islet cells are transplanted into diabetic mice, accordi...e of the journal Transplantation. Pancreatic islet cell transplantation has become a promising treatment for type 1 diabetes in humans in recent years....Laboratory studies show a natural protein analog may fix insulin-making cells isolated from pancreas
...not only stimulates the insulin-making capacity of islet cells in the pancreas, but that the compound actua...lly makes new insulin, increases the growth of new islet cells and prevents overworked islets from dying prematurely. The study, reported in the December iss...JCI Table of Contents, November 14, 2003
...nction in murine models of autoimmune diabetes and islet transplantation in the November 14 issue of the Jo...ncreased expression of Irs2 in beta cells improves islet transplantation, as significantly fewer islets were required to normalize serum glucose levels. The ...Regeneration of insulin-producing islets may lead to diabetes cure
...ppear to develop into insulin-producing pancreatic islet cells in adult animals. This surprising finding f.... "By accomplishing effective, robust and durable islet regeneration, this discovery opens up an entirely new approach to diabetes treatment." David M. Nat...Molecule expressed early in pregnancy may help patients tolerate transplants
...ork to patients. In the lab, Dr. Grandas is doing islet cell transplants which include the insulin-producing beta cells of the pancreas - to cure diabetes in rats. With his new NIH grant, Dr. Horusko is going to use HLA-G to modify the dendritic cells of the donor animal then inject them into the recipie...Joslin and Beth Israel Deaconess Medical Center sign new joint venture clinical agreement
...reas transplantation as well as clinical trials of islet cell transplantation; high-risk pregnancy; and obesity, a major risk factor for the development of type 2 diabetes. Joslin and BIDMC will continue existing programs in vascular surgery for diabetes complications; clinical endocrinology; nephrology; ...Chemical turns stem cells into neurons say scientists at Scripps Research Institute
...betes, an autoimmune condition in which pancreatic islet cells are destroyed by the body's immune system. B...se stem cells have the power to differentiate into islet cells, stem cell therapy could potentially cure this chronic condition. However bright this promise,...Russell Berrie Foundation gift to Columbia University propels diabetes treatment into new era
...icians could cure or ameliorate the illness. Whole islet transplants are an example of such treatment. However, human islets are a very limited resource. New means of creating insulin-producing cells are needed. Diabetes research in cellular therapy is directed at engineering cells to produce insulin. Suc...International Congress of the Transplantation Society beginning Sunday
...tines, or of tissues and cells, such as pancreatic islet cells, corneas, bone even hands. Although no official figures are available, it is estimated that between 150,000 and 200,000 people throughout the world are waiting for transplants on any given day. About 65,000 transplants are performed each year...Hormone prompts adult stem cells to differentiate into islet cells
...that a naturally occurring hormone can cause adult islet stem cells to mature into pancreatic beta cells, t...w provide evidence that the hormone may also cause islet stem cells to differentiate, or mature, into true beta cells. In a 2001 study, the team identified ...